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    SKT5 Skt5p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852218, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SKT5
    Official Full Name
    Skt5p
    Primary source
    SGD:S000000157
    Locus tag
    YBL061C
    See related
    AllianceGenome:SGD:S000000157; FungiDB:YBL061C; VEuPathDB:YBL061C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CAL2; CHS4; CSD4
    Summary
    Enables enzyme activator activity. Involved in chitin biosynthetic process. Located in cellular bud neck and incipient cellular bud site. Orthologous to human DELE1 (DAP3 binding cell death enhancer 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SKT5 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (105316..107406, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene thioredoxin peroxidase PRX1 Neighboring gene Kip1p Neighboring gene Arf family guanine nucleotide exchange factor YEL1 Neighboring gene Cmc2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A mutant allele skt5 affecting protoplast regeneration and killer toxin resistance has double mutations in its wild-type structural gene in Saccharomyces cerevisiae. Kawamoto S, et al. Biosci Biotechnol Biochem, 1993 Aug. PMID 7764021
    2. Characterization of CHS4 (CAL2), a gene of Saccharomyces cerevisiae involved in chitin biosynthesis and allelic to SKT5 and CSD4. Trilla JA, et al. Yeast, 1997 Jul. PMID 9234668
    3. The Candida albicans CHS4 gene complements a Saccharomyces cerevisiae skt5/chs4 mutation and is involved in chitin biosynthesis. Sudoh M, et al. Microbiology (Reading), 1999 Jul. PMID 10439400
    4. Prenylation of Saccharomyces cerevisiae Chs4p Affects Chitin Synthase III activity and chitin chain length. Grabińska KA, et al. Eukaryot Cell, 2007 Feb. PMID 17142567, Free PMC Article
    5. Control of chitin synthesis through Shc1p, a functional homologue of Chs4p specifically induced during sporulation. Sanz M, et al. Mol Microbiol, 2002 Mar. PMID 11918806

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Transient septin sumoylation steers a Fir1-Skt5 protein complex between the split septin ring.
      Title: Transient septin sumoylation steers a Fir1-Skt5 protein complex between the split septin ring.
    2. Hof1 binds to the Sel1-like repeats (SLRs) of Chs4 via its F-BAR domain and inhibits Chs3-mediated chitin synthesis during cytokinesis. In addition, Hof1 is required for rapid accumulation as well as efficient removal of Chs4 at the division site.
      Title: Hof1 and Chs4 Interact via F-BAR Domain and Sel1-like Repeats to Control Extracellular Matrix Deposition during Cytokinesis.
    3. Results suggest that Chs4p promotes Chs3p translocation into the plasma membrane in a stable and active form, and that proper chitin synthase III turnover is maintained through the endocytic internalization of Chs3p.
      Title: Chitin synthase III requires Chs4p-dependent translocation of Chs3p into the plasma membrane.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables enzyme activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables enzyme activator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chitin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chitin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fungal-type cell wall organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cellular bud neck HDA PubMed 
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in incipient cellular bud site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Skt5p
    NP_009492.1
    • Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      105316..107406 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178301.1 → NP_009492.1  TPA: Skt5p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009492.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPT8, P34226, Q02215
      UniProtKB/TrEMBL
      A6ZKN7, B3LNJ7
      Conserved Domains (3) summary
      smart00671
      Location:499 → 534
      SEL1; Sel1-like repeats
      COG0790
      Location:245 → 505
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:407 → 436
      SLR; SLR repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34226.1

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