TIM18 Tim18p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: TIM18
Official Full Name: Tim18p
Primary source: SGD:S000005823
Locus tag: YOR297C
See related: AllianceGenome:SGD:S000005823; FungiDB:YOR297C; VEuPathDB:YOR297C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Contributes to protein transmembrane transporter activity. Involved in several processes, including cellular response to oxidative stress; protein insertion into mitochondrial inner membrane; and response to arsenic-containing substance. Located in mitochondrion. Part of TIM22 mitochondrial import inner membrane insertion complex. Human ortholog(s) of this gene implicated in Carney-Stratakis syndrome; mitochondrial complex II deficiency; and paraganglioma. Orthologous to human SDHD (succinate dehydrogenase complex subunit D). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Tim18 is important for yeast cell death induced by arsenic, and it may act downstream of ROS production.
Title: Tim18, a component of the mitochondrial translocator, mediates yeast cell death induced by arsenic.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
contributes_to protein transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to protein transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein insertion into mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein insertion into mitochondrial inner membrane	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in response to arsenic-containing substance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to osmotic stress	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of TIM22 mitochondrial import inner membrane insertion complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TIM22 mitochondrial import inner membrane insertion complex	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial envelope	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

NP_014940.4

Component of the mitochondrial TIM22 complex; involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex