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    PPN2 putative serine/threonine-protein phosphatase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855504, updated on 17-Dec-2024

    Summary

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    Official Symbol
    PPN2
    Official Full Name
    putative serine/threonine-protein phosphatase
    Primary source
    SGD:S000005161
    Locus tag
    YNL217W
    See related
    AllianceGenome:SGD:S000005161; FungiDB:YNL217W; VEuPathDB:YNL217W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables endopolyphosphatase activity. Involved in cellular response to phosphate starvation and polyphosphate catabolic process. Located in fungal-type vacuole and vacuolar lumen. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PPN2 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (240331..241311)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene dolichyl-P-Man:Man(6)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferase Neighboring gene ssDNA-dependent ATPase MGS1 Neighboring gene DNA-binding transcription factor RAP1 Neighboring gene Ies2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inorganic Polyphosphate and Physiological Properties of Saccharomyces cerevisiae Yeast Overexpressing Ppn2. Ryazanova LP, et al. Biochemistry (Mosc), 2020 Apr. PMID 32569559
    2. A Screen for Candidate Targets of Lysine Polyphosphorylation Uncovers a Conserved Network Implicated in Ribosome Biogenesis. Bentley-DeSousa A, et al. Cell Rep, 2018 Mar 27. PMID 29590613
    3. Ppn2 endopolyphosphatase overexpressed in Saccharomyces cerevisiae: Comparison with Ppn1, Ppx1, and Ddp1 polyphosphatases. Andreeva N, et al. Biochimie, 2019 Aug. PMID 31175919
    4. Knowledge-based analysis of microarray gene expression data by using support vector machines. Brown MP, et al. Proc Natl Acad Sci U S A, 2000 Jan 4. PMID 10618406, Free PMC Article
    5. Ppn2, a novel Zn(2+)-dependent polyphosphatase in the acidocalcisome-like yeast vacuole. Gerasimaitė R, et al. J Cell Sci, 2017 May 1. PMID 28302909

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables endopolyphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables endopolyphosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables endopolyphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endopolyphosphatase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables endopolyphosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to phosphate starvation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in polyphosphate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in polyphosphate catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in polyphosphate catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in polyphosphate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole HDA PubMed 
    located_in fungal-type vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fungal-type vacuole membrane HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar lumen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative serine/threonine-protein phosphatase
    NP_014182.1
    • Zn2+-dependent endopolyphosphatase; required with PPN1 to mobilize polyphosphate stores in response to phosphate starvation; member of the PPP-superfamily of metalloproteases; directly involved in adaptation to mild alkaline conditions through polyphosphate hydrolysis; localizes to the vacuolar lumen via the MVB pathway; null mutant is highly sensitive to azaserine and resistant to sodium-O-vandate

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      240331..241311
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183055.1 → NP_014182.1  TPA: putative serine/threonine-protein phosphatase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014182.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0X3, P40152
      UniProtKB/TrEMBL
      A6ZRM3, B3LP61, B5VQJ4, C7GPE0, C8ZG16, G2WLP6, N1P440
      Conserved Domains (1) summary
      cd00144
      Location:64 → 307
      MPP_PPP_family; phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40152.1

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