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    PET111 Pet111p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855299, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PET111
    Official Full Name
    Pet111p
    Primary source
    SGD:S000004870
    Locus tag
    YMR257C
    See related
    AllianceGenome:SGD:S000004870; FungiDB:YMR257C; VEuPathDB:YMR257C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables translation regulator activity. Involved in mitochondrial cytochrome c oxidase assembly and positive regulation of mitochondrial translation. Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PET111 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (779629..782031, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Gfd1p Neighboring gene cytochrome c oxidase subunit VII Neighboring gene Roy1p Neighboring gene tRNA methylation protein TRM732

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Saccharomyces cerevisiae positive regulatory gene PET111 encodes a mitochondrial protein that is translated from an mRNA with a long 5' leader. Strick CA, et al. Mol Cell Biol, 1987 Aug. PMID 2823103, Free PMC Article
    2. Pet111p, an inner membrane-bound translational activator that limits expression of the Saccharomyces cerevisiae mitochondrial gene COX2. Green-Willms NS, et al. J Biol Chem, 2001 Mar 2. PMID 11106667
    3. Alteration of the Saccharomyces cerevisiae COX2 mRNA 5'-untranslated leader by mitochondrial gene replacement and functional interaction with the translational activator protein PET111. Mulero JJ, et al. Mol Biol Cell, 1993 Dec. PMID 8167413, Free PMC Article
    4. Mitochondrial assembly in respiration-deficient mutants of Saccharomyces cerevisiae. I. Effect of nuclear mutations on mitochondrial protein synthesis. Ebner E, et al. J Biol Chem, 1973 Aug 10. PMID 4358612
    5. PET111, a Saccharomyces cerevisiae nuclear gene required for translation of the mitochondrial mRNA encoding cytochrome c oxidase subunit II. Poutre CG, et al. Genetics, 1987 Apr. PMID 3034718, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Yeast Mitochondrial Translation Initiation Factor 3 Interacts with Pet111p to Promote COX2 mRNA Translation.
      Title: Yeast Mitochondrial Translation Initiation Factor 3 Interacts with Pet111p to Promote COX2 mRNA Translation.
    2. Overexpression of the COX2 mRNA-specific translational activator Pet111 inhibits translation of COX1 mRNA and interferes with cytochrome c oxidase assembly.
      Title: Overexpression of the COX2 translational activator, Pet111p, prevents translation of COX1 mRNA and cytochrome c oxidase assembly in mitochondria of Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables translation regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial cytochrome c oxidase assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitochondrial translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Pet111p
    NP_013984.1
    • Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      779629..782031 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182764.1 → NP_013984.1  TPA: Pet111p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013984.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W083, P08468
      UniProtKB/TrEMBL
      B3LME5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08468.2

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