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    EAR1 Ear1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855207, updated on 9-Dec-2024

    Summary

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    Official Symbol
    EAR1
    Official Full Name
    Ear1p
    Primary source
    SGD:S000004781
    Locus tag
    YMR171C
    See related
    AllianceGenome:SGD:S000004781; FungiDB:YMR171C; VEuPathDB:YMR171C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ubiquitin-like ligase-substrate adaptor activity. Involved in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Located in endosome. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See EAR1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (603868..605520, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene aldehyde dehydrogenase (NAD(+)) ALD3 Neighboring gene aldehyde dehydrogenase (NAD(+)) ALD2 Neighboring gene Hot1p Neighboring gene DNA damage-responsive protein 48

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ear1p and Ssh4p are new adaptors of the ubiquitin ligase Rsp5p for cargo ubiquitylation and sorting at multivesicular bodies. Léon S, et al. Mol Biol Cell, 2008 Jun. PMID 18367543, Free PMC Article
    2. Localization of a subset of yeast mRNAs depends on inheritance of endoplasmic reticulum. Fundakowski J, et al. Traffic, 2012 Dec. PMID 22994588
    3. Retrograde trafficking and quality control of yeast synaptobrevin, Snc1, are conferred by its transmembrane domain. Ma M, et al. Mol Biol Cell, 2019 Jul 1. PMID 31067149, Free PMC Article
    4. Rsp5 Ubiquitin ligase-mediated quality control system clears membrane proteins mistargeted to the vacuole membrane. Sardana R, et al. J Cell Biol, 2019 Jan 7. PMID 30361468, Free PMC Article
    5. Use of a wine yeast deletion collection reveals genes that influence fermentation performance under low-nitrogen conditions. Peter JJ, et al. FEMS Yeast Res, 2018 May 1. PMID 29425293

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ear1p/Ssh4p recruit Rsp5p and assist it in its function at multivesicular bodies by directing the ubiquitylation of specific cargoes.
      Title: Ear1p and Ssh4p are new adaptors of the ubiquitin ligase Rsp5p for cargo ubiquitylation and sorting at multivesicular bodies.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endosome HDA PubMed 
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ear1p
    NP_013894.1
    • Specificity factor required for Rsp5p-dependent ubiquitination; also required for sorting of specific cargo proteins at the multivesicular body; mRNA is targeted to the bud via the mRNA transport system involving She2p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      603868..605520 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182675.1 → NP_013894.1  TPA: Ear1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013894.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZZ3, Q03212, Q03830
      UniProtKB/TrEMBL
      A6ZMN0, C7GSR7, N1NXG9
      Conserved Domains (1) summary
      cd12910
      Location:185 → 374
      SPRY_SSH4_like; SPRY domain in SSH4 and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03212.1

    Gene LinkOut

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