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    CTF13 Ctf13p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855119, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CTF13
    Official Full Name
    Ctf13p
    Primary source
    SGD:S000004700
    Locus tag
    YMR094W
    See related
    AllianceGenome:SGD:S000004700; FungiDB:YMR094W; VEuPathDB:YMR094W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables DNA binding activity, bending. Involved in kinetochore assembly and septin ring assembly. Part of CBF3 complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CTF13 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (455825..457261)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Aip1p Neighboring gene snoRNA-binding rRNA-processing protein UTP15 Neighboring gene putative pyridoxal 5'-phosphate synthase Neighboring gene pyridoxine biosynthesis protein SNZ1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of essential components of the S. cerevisiae kinetochore. Doheny KF, et al. Cell, 1993 May 21. PMID 8500169, Free PMC Article
    2. A 240 kd multisubunit protein complex, CBF3, is a major component of the budding yeast centromere. Lechner J, et al. Cell, 1991 Feb 22. PMID 1997204
    3. Mutations in the yeast cyclin-dependent kinase Cdc28 reveal a role in the spindle assembly checkpoint. Kitazono AA, et al. Mol Genet Genomics, 2003 Aug. PMID 12827501
    4. A case of convergent-gene interference in the budding yeast knockout library causing chromosome instability. Gordon MR, et al. G3 (Bethesda), 2021 May 7. PMID 33724427, Free PMC Article
    5. Yeast kinetochores do not stabilize Stu2p-dependent spindle microtubule dynamics. Pearson CG, et al. Mol Biol Cell, 2003 Oct. PMID 14517328, Free PMC Article

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CBF3 acts as a passenger protein to coordinate chromosome segregation with cytokinesis
      Title: A novel role for the CBF3 kinetochore-scaffold complex in regulating septin dynamics and cytokinesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding, bending IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in kinetochore assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in septin ring assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CBF3 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ctf13p
    NP_013812.1
    • Subunit of the CBF3 complex; F-box protein of the leucine-rich-repeat family; required for assembly of the complex; CBF3 binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      455825..457261
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182594.1 → NP_013812.1  TPA: Ctf13p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013812.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZR7, P35203
      UniProtKB/TrEMBL
      A6ZMF1, B3LLY5, C7GL32, C8ZEU6, N1P5I4
      Conserved Domains (1) summary
      cd19611
      Location:163 → 477
      Ctf13_LRR_LRR-insertion; leucine-rich-repeat (LRR) domain and LRR insertion domain of centromere DNA-binding protein complex CBF3 subunit C (Ctf13)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35203.3

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