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    PDP3 Pdp3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851177, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PDP3
    Official Full Name
    Pdp3p
    Primary source
    SGD:S000004447
    Locus tag
    YLR455W
    See related
    AllianceGenome:SGD:S000004447; FungiDB:YLR455W; VEuPathDB:YLR455W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables RNA polymerase II complex binding activity and chromatin binding activity. Involved in positive regulation of transcription elongation by RNA polymerase II. Located in cytosol. Part of NuA3b histone acetyltransferase complex. Is active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PDP3 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (1053629..1054543)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Fmp27p Neighboring gene tRNA-Ile Neighboring gene pyridoxal 5'-phosphate synthase Neighboring gene Nbp1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NDF is a transcription factor that stimulates elongation by RNA polymerase II. Fei J, et al. Genes Dev, 2022 Mar 1. PMID 35273076, Free PMC Article
    2. The PWWP domain of the human oncogene WHSC1L1/NSD3 induces a metabolic shift toward fermentation. Rona GB, et al. Oncotarget, 2017 Aug 15. PMID 28903324, Free PMC Article
    3. (1) H NMR metabolomics reveals increased glutaminolysis upon overexpression of NSD3s or Pdp3 in Saccharomyces cerevisiae. Rona GB, et al. J Cell Biochem, 2019 Apr. PMID 30320908
    4. Mechanism of selectivity of an angiogenesis inhibitor from screening a genome-wide set of Saccharomyces cerevisiae deletion strains. Dilda PJ, et al. J Natl Cancer Inst, 2005 Oct 19. PMID 16234568
    5. Histone H3K4 and H3K36 Methylation Independently Recruit the NuA3 Histone Acetyltransferase in Saccharomyces cerevisiae. Martin BJ, et al. Genetics, 2017 Mar. PMID 28108585, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA polymerase II complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of transcription elongation by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription elongation by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NuA3 histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of NuA3b histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    located_in nucleus HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Pdp3p
    NP_013560.3
    • Component of the NuA3b histone acetyltransferase complex; binds to Pol II and stimulates elongation; regulates interaction between NuA3b and H3K36me3 at transcribed regions of genes; contains PWWP domain; protein abundance increases in response to DNA replication stress; relocalizes to the cytosol in response to hypoxia; extensive sequence similarity (
      25% identity;
      39% similarity) to the N-terminal region of human NDF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      1053629..1054543
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182343.3 → NP_013560.3  TPA: Pdp3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013560.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZ89, Q06188
      UniProtKB/TrEMBL
      A7A1X6, B3RHW3, C7GUD6, C8ZE61, G2WJR6, N1NZZ1
      Conserved Domains (1) summary
      cd05840
      Location:5 → 96
      SPBC215_ISWI_like; The PWWP domain is a component of the S. pombe hypothetical protein SPBC215, as well as ISWI complex protein 4. The ISWI (imitation switch) proteins are ATPases responsible for chromatin remodeling in eukaryotes, and SPBC215 is proposed to also bind ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06188.1

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