U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    LIA1 deoxyhypusine monooxygenase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853534, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    LIA1
    Official Full Name
    deoxyhypusine monooxygenase
    Primary source
    SGD:S000003831
    Locus tag
    YJR070C
    See related
    AllianceGenome:SGD:S000003831; FungiDB:YJR070C; VEuPathDB:YJR070C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MMD1
    Summary
    Enables deoxyhypusine monooxygenase activity. Involved in microtubule cytoskeleton organization and peptidyl-lysine modification to peptidyl-hypusine. Located in cytoplasm and nucleus. Orthologous to human DOHH (deoxyhypusine hydroxylase). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See LIA1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (569621..570598, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene replication factor C subunit 2 Neighboring gene nucleoside triphosphate pyrophosphohydrolase HAM1 Neighboring gene GTPase NPA3 Neighboring gene bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Evidence for conformational changes in the yeast deoxyhypusine hydroxylase Lia1 upon iron displacement from its active site. Cano VS, et al. Amino Acids, 2010 Feb. PMID 19956996, Free PMC Article
    2. Mapping eIF5A binding sites for Dys1 and Lia1: in vivo evidence for regulation of eIF5A hypusination. Thompson GM, et al. FEBS Lett, 2003 Dec 18. PMID 14675757
    3. Mmd1p, a novel, conserved protein essential for normal mitochondrial morphology and distribution in the fission yeast Schizosaccharomyces pombe. Weir BA, et al. Mol Biol Cell, 2004 Apr. PMID 14767070, Free PMC Article
    4. Molecular cloning, expression, and structural prediction of deoxyhypusine hydroxylase: a HEAT-repeat-containing metalloenzyme. Park JH, et al. Proc Natl Acad Sci U S A, 2006 Jan 3. PMID 16371467, Free PMC Article
    5. Mutations in the nucleolar proteins Tma23 and Nop6 suppress the malfunction of the Nep1 protein. Buchhaupt M, et al. FEMS Yeast Res, 2007 Sep. PMID 17425675

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Iron is essential for Lia1 activity since its loss renders the enzyme totally inactive.
      Title: Evidence for conformational changes in the yeast deoxyhypusine hydroxylase Lia1 upon iron displacement from its active site.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables deoxyhypusine monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables deoxyhypusine monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables deoxyhypusine monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables deoxyhypusine monooxygenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptidyl-lysine modification to peptidyl-hypusine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptidyl-lysine modification to peptidyl-hypusine IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    deoxyhypusine monooxygenase
    NP_012604.1
    • Deoxyhypusine hydroxylase; HEAT-repeat containing metalloenzyme that catalyzes hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      569621..570598 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181728.1 → NP_012604.1  TPA: deoxyhypusine monooxygenase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012604.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWP1, P47120
      UniProtKB/TrEMBL
      A6ZQ29, B3LQF7, C7GMD3, C8ZBL8, G2WH75, N1P049
      Conserved Domains (2) summary
      COG1413
      Location:13 → 322
      HEAT; HEAT repeat [General function prediction only]
      sd00044
      Location:187 → 241
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47120.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous