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    Ephb3 Eph receptor B3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287989, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ephb3provided by RGD
    Official Full Name
    Eph receptor B3provided by RGD
    Primary source
    RGD:1305602
    See related
    EnsemblRapid:ENSRNOG00000031801 AllianceGenome:RGD:1305602
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable axon guidance receptor activity and transmembrane-ephrin receptor activity. Predicted to be involved in several processes, including ephrin receptor signaling pathway; neuron projection development; and tube morphogenesis. Predicted to act upstream of or within central nervous system projection neuron axonogenesis and retinal ganglion cell axon guidance. Predicted to be active in dendrite and plasma membrane. Biomarker of malaria. Orthologous to human EPHB3 (EPH receptor B3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 35.2), Brain (RPKM 12.9) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Ephb3 in Genome Data Viewer
    Location:
    11q23
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (93345098..93363775, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (79840668..79859345, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (83527960..83546742, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene SNW domain containing 1, pseudogene 3 Neighboring gene nudix hydrolase 2, pseudogene 1 Neighboring gene uncharacterized LOC134481030 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables GPI-linked ephrin receptor activity  
    enables axon guidance receptor activity  
    enables boss receptor activity  
    enables brain-derived neurotrophic factor receptor activity  
    enables ephrin receptor activity  
    enables epidermal growth factor receptor activity  
    enables fibroblast growth factor receptor activity  
    enables hepatocyte growth factor receptor activity  
    enables insulin receptor activity  
    enables insulin-like growth factor receptor activity  
    enables macrophage colony-stimulating factor receptor activity  
    enables placental growth factor receptor activity  
    enables platelet-derived growth factor alpha-receptor activity  
    enables platelet-derived growth factor beta-receptor activity  
    enables protein tyrosine kinase collagen receptor activity  
    enables stem cell factor receptor activity  
    enables transmembrane-ephrin receptor activity  
    enables vascular endothelial growth factor receptor activity  
    Items 1 - 25 of 35
    Process Evidence Code Pubs
    involved_in Kit signaling pathway  
    involved_in angiogenesis  
    involved_in axon guidance  
    acts_upstream_of_or_within axon guidance  
    involved_in axon guidance  
    involved_in axonal fasciculation  
    involved_in brain-derived neurotrophic factor receptor signaling pathway  
    involved_in cell migration  
    acts_upstream_of_or_within central nervous system projection neuron axonogenesis  
    involved_in collagen-activated tyrosine kinase receptor signaling pathway  
    involved_in corpus callosum development  
    involved_in dendritic spine development  
    involved_in dendritic spine morphogenesis  
    involved_in digestive tract morphogenesis  
    involved_in ephrin receptor signaling pathway  
    involved_in ephrin receptor signaling pathway  
    involved_in epidermal growth factor receptor signaling pathway  
    involved_in fibroblast growth factor receptor signaling pathway  
    involved_in hepatocyte growth factor receptor signaling pathway  
    involved_in insulin receptor signaling pathway  
    involved_in insulin-like growth factor receptor signaling pathway  
    involved_in macrophage colony-stimulating factor signaling pathway  
    involved_in platelet-derived growth factor receptor-alpha signaling pathway  
    involved_in platelet-derived growth factor receptor-beta signaling pathway  
    involved_in positive regulation of synapse assembly  
    involved_in protein autophosphorylation  
    involved_in regulation of axonogenesis  
    involved_in regulation of cell-cell adhesion  
    acts_upstream_of_or_within retinal ganglion cell axon guidance  
    involved_in roof of mouth development  
    involved_in substrate adhesion-dependent cell spreading  
    involved_in thymus development  
    involved_in urogenital system development  
    involved_in vascular endothelial growth factor receptor-1 signaling pathway  
    involved_in vascular endothelial growth factor signaling pathway  
    Items 1 - 25 of 35
    Component Evidence Code Pubs
    is_active_in dendrite  
    is_active_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    ephrin type-B receptor 3
    Names
    EPH-like tyrosine kinase-2
    NP_001401917.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001414988.1NP_001401917.1  ephrin type-B receptor 3 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A0A8I5ZVE3, A6JS76, D3ZH39
      Related
      ENSRNOP00000083114.1, ENSRNOT00000119527.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      93345098..93363775 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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