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    Rpl17 ribosomal protein L17 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291434, updated on 9-Dec-2024

    Summary

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    Symbol
    Rpl17provided by RGD
    Full Name
    ribosomal protein L17provided by RGD
    Primary source
    RGD:1303019
    See related
    EnsemblRapid:ENSRNOG00000018680 AllianceGenome:RGD:1303019
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ASI; rpL23
    Summary
    Enables large ribosomal subunit rRNA binding activity. Involved in cellular response to amino acid starvation and positive regulation of G1/S transition of mitotic cell cycle. Located in A band. Part of cytosolic large ribosomal subunit. Orthologous to human RPL17 (ribosomal protein L17). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 2031.6), Thymus (RPKM 1846.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rpl17 in Genome Data Viewer
    Location:
    18q12.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (70856275..70859388)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (68581141..68584253)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (70969733..70972839)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene transfer RNA proline (anticodon AGG) 92 Neighboring gene solute carrier family 25 member 5, pseudogene 11 Neighboring gene small nucleolar RNA SNORD58 Neighboring gene small nucleolar RNA SNORD58 Neighboring gene similar to human chromosome 18 open reading frame 32 Neighboring gene small nucleolar RNA, C/D box 58B Neighboring gene U6 spliceosomal RNA Neighboring gene dymeclin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of an amino acid-regulated mRNA (amino acid starvation-induced) in rat hepatoma cells. Shay NF, et al. J Biol Chem, 1990 Oct 15. PMID 2211664
    2. Liver-specific induction of ribosomal protein gene expression by amino acid starvation in rats. Hitomi Y, et al. Biosci Biotechnol Biochem, 1993 Jul. PMID 7765311
    3. Identification of an amino acid-regulated mRNA from rat liver as the mammalian equivalent of bacterial ribosomal protein L22. Laine RO, et al. J Biol Chem, 1991 Sep 15. PMID 1894596
    4. Ribosomal protein L17, RpL17, is an inhibitor of vascular smooth muscle growth and carotid intima formation. Smolock EM, et al. Circulation, 2012 Nov 13. PMID 23065385, Free PMC Article
    5. The primary structure of rat ribosomal protein L17. Suzuki K, et al. Biochem Biophys Res Commun, 1991 Jul 15. PMID 2069571

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112577

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables large ribosomal subunit rRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to amino acid starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to amino acid starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in A band IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    large ribosomal subunit protein uL22
    Names
    60S ribosomal protein L17
    L23
    amino acid starvation-induced protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201415.2 → NP_958818.1  large ribosomal subunit protein uL22

      See identical proteins and their annotated locations for NP_958818.1

      Status: VALIDATED

      Source sequence(s)
      FQ222545
      UniProtKB/Swiss-Prot
      P24049, Q4G093
      UniProtKB/TrEMBL
      A6KRH3, D3Z9G9
      Conserved Domains (1) summary
      PTZ00178
      Location:1 → 165
      PTZ00178; 60S ribosomal protein L17; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      70856275..70859388
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277168.1 → XP_063133238.1  large ribosomal subunit protein uL22 isoform X2

      UniProtKB/TrEMBL
      A6KRH4

    2. XM_039096639.2 → XP_038952567.1  large ribosomal subunit protein uL22 isoform X1

      UniProtKB/Swiss-Prot
      P24049, Q4G093
      UniProtKB/TrEMBL
      A6KRH3, D3Z9G9
      Conserved Domains (1) summary
      PTZ00178
      Location:1 → 165
      PTZ00178; 60S ribosomal protein L17; Provisional

    3. XM_063277167.1 → XP_063133237.1  large ribosomal subunit protein uL22 isoform X1

      UniProtKB/Swiss-Prot
      P24049, Q4G093
      UniProtKB/TrEMBL
      A6KRH3, D3Z9G9
      Related
      ENSRNOP00000025217.7, ENSRNOT00000025217.8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P24049.3 GenPept UniProtKB/Swiss-Prot:P24049

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