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    Ppp2r2b protein phosphatase 2, regulatory subunit B, beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 60660, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ppp2r2bprovided by RGD
    Official Full Name
    protein phosphatase 2, regulatory subunit B, betaprovided by RGD
    Primary source
    RGD:631441
    See related
    EnsemblRapid:ENSRNOG00000018851 AllianceGenome:RGD:631441
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pppr2b2
    Summary
    Predicted to enable protein phosphatase regulator activity. Involved in several processes, including mitochondrion organization; positive regulation of neuron apoptotic process; and protein targeting to mitochondrion. Located in mitochondrial outer membrane. Part of protein phosphatase type 2A complex. Human ortholog(s) of this gene implicated in Alzheimer's disease; brain disease; breast cancer; and spinocerebellar ataxia type 12. Orthologous to human PPP2R2B (protein phosphatase 2 regulatory subunit Bbeta). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 247.9), Testes (RPKM 74.2) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ppp2r2b in Genome Data Viewer
    Location:
    18p11
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (34904686..35357299, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (34653716..35080889, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (36985709..37421383, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene ubiquitin-40S ribosomal protein S27a pseudogene Neighboring gene G protein-coupled receptor 151 Neighboring gene uncharacterized LOC134482938 Neighboring gene uncharacterized LOC108353168 Neighboring gene U6 spliceosomal RNA Neighboring gene U6 spliceosomal RNA Neighboring gene serine/threonine kinase 32A Neighboring gene rhox homeobox family member 1-like Neighboring gene dihydropyrimidinase-like 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Induction of PP2A Bβ, a regulator of IL-2 deprivation-induced T-cell apoptosis, is deficient in systemic lupus erythematosus. Crispín JC, et al. Proc Natl Acad Sci U S A, 2011 Jul 26. PMID 21746932, Free PMC Article
    2. A genetic variant in a PP2A regulatory subunit encoded by the PPP2R2B gene associates with altered breast cancer risk and recurrence. Vazquez A, et al. Int J Cancer, 2011 May 15. PMID 20669227, Free PMC Article
    3. Spinocerebellar ataxia type 12 identified in two Italian families may mimic sporadic ataxia. Brussino A, et al. Mov Disord, 2010 Jul 15. PMID 20629122
    4. The spinocerebellar ataxia 12 gene product and protein phosphatase 2A regulatory subunit Bbeta2 antagonizes neuronal survival by promoting mitochondrial fission. Dagda RK, et al. J Biol Chem, 2008 Dec 26. PMID 18940801, Free PMC Article
    5. Unfolding-resistant translocase targeting: a novel mechanism for outer mitochondrial membrane localization exemplified by the Bbeta2 regulatory subunit of protein phosphatase 2A. Dagda RK, et al. J Biol Chem, 2005 Jul 22. PMID 15923182, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Select PP2A heterotrimers oppose desensitization of the TrkA receptor tyrosine kinase, perhaps through dephosphorylation of inhibitory Ser/Thr phosphorylation sites on the receptor itself.
      Title: The protein phosphatase 2A regulatory subunits B'beta and B'delta mediate sustained TrkA neurotrophin receptor autophosphorylation and neuronal differentiation.
    2. spinocerebellar ataxia 12 gene product and protein phosphatase 2A regulatory subunit Bbeta2 antagonizes neuronal survival by promoting mitochondrial fission [SCA12]
      Title: The spinocerebellar ataxia 12 gene product and protein phosphatase 2A regulatory subunit Bbeta2 antagonizes neuronal survival by promoting mitochondrial fission.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial fission IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitochondrial fragmentation involved in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron differentiation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in positive regulation of neuron apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein targeting to mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatid development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein phosphatase type 2A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase type 2A complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein phosphatase type 2A complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
    Names
    BRbeta B-regulatory subunit of protein phosphatase 2A
    NP_001389311.1
    NP_071545.2
    XP_017456515.1
    XP_017456517.1
    XP_038952986.1
    XP_038952987.1
    XP_038952988.1
    XP_038952990.1
    XP_038952991.1
    XP_038952992.1
    XP_038952993.1
    XP_038952994.1
    XP_038952996.1
    XP_038952997.1
    XP_038952999.1
    XP_038953000.1
    XP_063133596.1
    XP_063133597.1
    XP_063133598.1
    XP_063133599.1
    XP_063133601.1
    XP_063133602.1
    XP_063133603.1
    XP_063133604.1
    XP_063133605.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001402382.1 → NP_001389311.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/Swiss-Prot
      P36877, Q80W84
      UniProtKB/TrEMBL
      A6J3L2, Z4YNW7
      Related
      ENSRNOP00000071824.1, ENSRNOT00000079585.3

    2. NM_022209.4 → NP_071545.2  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform 1

      See identical proteins and their annotated locations for NP_071545.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A6J3L0, Z4YNW7
      Related
      ENSRNOP00000111041.1, ENSRNOT00000131113.1
      Conserved Domains (3) summary
      COG5170
      Location:25 → 441
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:30 → 78
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:24 → 369
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. NR_073588.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      34904686..35357299 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277535.1 → XP_063133605.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X14

      UniProtKB/TrEMBL
      A6K6P2

    2. XM_039097058.2 → XP_038952986.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X2

      UniProtKB/TrEMBL
      Z4YNW7
      Conserved Domains (2) summary
      COG5170
      Location:25 → 468
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:30 → 105
      7WD40; WD40 repeat [structural motif]

    3. XM_017601028.3 → XP_017456517.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X12

      UniProtKB/TrEMBL
      A0A0G2K165, Z4YNW7
      Related
      ENSRNOP00000093860.2, ENSRNOT00000118131.2

    4. XM_063277532.1 → XP_063133602.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X12

      UniProtKB/TrEMBL
      A0A0G2K165, Z4YNW7

    5. XM_063277533.1 → XP_063133603.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X12

      UniProtKB/TrEMBL
      A0A0G2K165, Z4YNW7

    6. XM_039097068.2 → XP_038952996.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X7

      UniProtKB/TrEMBL
      Z4YNW7
      Conserved Domains (2) summary
      COG5170
      Location:6 → 447
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:9 → 84
      7WD40; WD40 repeat [structural motif]

    7. XM_039097065.2 → XP_038952993.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X7

      UniProtKB/TrEMBL
      Z4YNW7
      Related
      ENSRNOP00000107558.1, ENSRNOT00000157140.1
      Conserved Domains (2) summary
      COG5170
      Location:6 → 447
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:9 → 84
      7WD40; WD40 repeat [structural motif]

    8. XM_063277528.1 → XP_063133598.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X3

      UniProtKB/TrEMBL
      Z4YNW7

    9. XM_039097060.2 → XP_038952988.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X3

      UniProtKB/TrEMBL
      Z4YNW7
      Conserved Domains (2) summary
      COG5170
      Location:22 → 465
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:27 → 102
      7WD40; WD40 repeat [structural motif]

    10. XM_039097066.2 → XP_038952994.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X7

      UniProtKB/TrEMBL
      Z4YNW7
      Conserved Domains (2) summary
      COG5170
      Location:6 → 447
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:9 → 84
      7WD40; WD40 repeat [structural motif]

    11. XM_063277531.1 → XP_063133601.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X12

      UniProtKB/TrEMBL
      A0A0G2K165, Z4YNW7

    12. XM_039097072.2 → XP_038953000.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X14

      UniProtKB/TrEMBL
      A6K6P2
      Conserved Domains (2) summary
      COG5170
      Location:2 → 283
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:21 → 57
      7WD40; WD40 repeat [structural motif]

    13. XM_039097069.2 → XP_038952997.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X8

      UniProtKB/TrEMBL
      Z4YNW7
      Related
      ENSRNOP00000041264.6, ENSRNOT00000041188.6
      Conserved Domains (2) summary
      COG5170
      Location:3 → 444
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:6 → 81
      7WD40; WD40 repeat [structural motif]

    14. XM_039097059.2 → XP_038952987.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X3

      UniProtKB/TrEMBL
      Z4YNW7
      Conserved Domains (2) summary
      COG5170
      Location:22 → 465
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:27 → 102
      7WD40; WD40 repeat [structural motif]

    15. XM_063277527.1 → XP_063133597.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X3

      UniProtKB/TrEMBL
      Z4YNW7

    16. XM_039097071.2 → XP_038952999.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X10

      UniProtKB/TrEMBL
      A0A8I6ANA4, Z4YNW7
      Related
      ENSRNOP00000096088.1, ENSRNOT00000097489.2
      Conserved Domains (2) summary
      COG5170
      Location:5 → 422
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:11 → 59
      7WD40; WD40 repeat [structural motif]

    17. XM_039097063.2 → XP_038952991.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X5

      UniProtKB/TrEMBL
      Z4YNW7
      Conserved Domains (2) summary
      COG5170
      Location:5 → 449
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:11 → 86
      7WD40; WD40 repeat [structural motif]

    18. XM_063277534.1 → XP_063133604.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X13

      UniProtKB/TrEMBL
      A0A8I6AXN0, Z4YNW7

    19. XM_039097064.2 → XP_038952992.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X6

      UniProtKB/TrEMBL
      Z4YNW7
      Related
      ENSRNOP00000081049.2, ENSRNOT00000112290.2
      Conserved Domains (2) summary
      COG5170
      Location:1 → 448
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:10 → 85
      7WD40; WD40 repeat [structural motif]

    20. XM_017601026.3 → XP_017456515.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X11

      UniProtKB/TrEMBL
      A0A8I5ZU97, Z4YNW7

    21. XM_063277529.1 → XP_063133599.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X9

      UniProtKB/TrEMBL
      Z4YNW7
      Related
      ENSRNOP00000071716.3, ENSRNOT00000091634.3

    22. XM_039097062.2 → XP_038952990.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X4

      UniProtKB/TrEMBL
      Z4YNW7
      Conserved Domains (2) summary
      COG5170
      Location:8 → 449
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:11 → 86
      7WD40; WD40 repeat [structural motif]

    23. XM_063277526.1 → XP_063133596.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1

      UniProtKB/TrEMBL
      A6K9H8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36877.2 GenPept UniProtKB/Swiss-Prot:P36877

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