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    Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29709, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gabrg2provided by RGD
    Official Full Name
    gamma-aminobutyric acid type A receptor subunit gamma 2provided by RGD
    Primary source
    RGD:61966
    See related
    EnsemblRapid:ENSRNOG00000003241 AllianceGenome:RGD:61966
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables GABA-A receptor activity and chloride channel activity. Contributes to GABA receptor activity. Involved in several processes, including GABAergic synaptic transmission; cellular response to zinc ion; and response to anesthetic. Located in cell surface; dendrite membrane; and inhibitory synapse. Part of GABA receptor complex. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic specialization membrane. Biomarker of fetal alcohol spectrum disorder and hepatic encephalopathy. Human ortholog(s) of this gene implicated in alcohol dependence; alcoholic liver cirrhosis; amphetamine abuse; brain disease (multiple); and heroin dependence. Orthologous to human GABRG2 (gamma-aminobutyric acid type A receptor subunit gamma2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 394.3) See more
    Orthologs
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    Genomic context

    See Gabrg2 in Genome Data Viewer
    Location:
    10q21
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (26876926..26965523, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (26374693..26463937, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (27090913..27179786, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene uncharacterized LOC103693305 Neighboring gene ribosomal protein S19, pseudogene 17 Neighboring gene uncharacterized LOC102548672 Neighboring gene uncharacterized LOC108352216 Neighboring gene gamma-aminobutyric acid type A receptor subunit alpha 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to GABA receptor activity PubMed 
    enables GABA-A receptor activity PubMed 
    enables GABA-A receptor activity  
    enables GABA-A receptor activity  
    enables GABA-A receptor activity PubMed 
    enables GABA-gated chloride ion channel activity  
    enables GABA-gated chloride ion channel activity  
    contributes_to GABA-gated chloride ion channel activity  
    enables GABA-gated chloride ion channel activity  
    contributes_to GABA-gated chloride ion channel activity  
    enables GABA-gated chloride ion channel activity  
    contributes_to benzodiazepine receptor activity  
    enables chloride channel activity PubMed 
    enables chloride channel activity  
    enables inhibitory extracellular ligand-gated monoatomic ion channel activity PubMed 
    enables protein binding PubMed 
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential  
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential  
    Items 1 - 25 of 32
    Process Evidence Code Pubs
    involved_in adult behavior  
    acts_upstream_of_or_within adult behavior  
    involved_in cellular response to histamine  
    involved_in cellular response to histamine  
    involved_in cellular response to histamine  
    involved_in cellular response to zinc ion PubMed 
    involved_in chemical synaptic transmission  
    acts_upstream_of_or_within chemical synaptic transmission  
    involved_in chloride transmembrane transport  
    involved_in chloride transmembrane transport  
    involved_in chloride transmembrane transport  
    involved_in chloride transport PubMed 
    involved_in gamma-aminobutyric acid signaling pathway  
    involved_in gamma-aminobutyric acid signaling pathway  
    acts_upstream_of_or_within gamma-aminobutyric acid signaling pathway  
    involved_in gamma-aminobutyric acid signaling pathway  
    involved_in gamma-aminobutyric acid signaling pathway PubMed 
    involved_in gamma-aminobutyric acid signaling pathway PubMed 
    involved_in inhibitory synapse assembly  
    involved_in inhibitory synapse assembly  
    involved_in inhibitory synapse assembly  
    involved_in inhibitory synapse assembly  
    involved_in post-embryonic development  
    acts_upstream_of_or_within post-embryonic development  
    involved_in regulation of postsynaptic membrane potential  
    involved_in regulation of postsynaptic membrane potential  
    involved_in response to anesthetic PubMed 
    involved_in response to ethanol PubMed 
    involved_in synaptic transmission, GABAergic  
    involved_in synaptic transmission, GABAergic PubMed 
    involved_in synaptic transmission, GABAergic  
    involved_in synaptic transmission, GABAergic PubMed 
    Items 1 - 25 of 32
    Items 1 - 20 of 27
    Component Evidence Code Pubs
    part_of GABA receptor complex PubMed 
    part_of GABA-A receptor complex  
    part_of GABA-A receptor complex  
    part_of GABA-A receptor complex  
    part_of GABA-A receptor complex  
    is_active_in GABA-ergic synapse PubMed 
    located_in GABA-ergic synapse  
    is_active_in GABA-ergic synapse  
    located_in axon  
    located_in axon  
    located_in cell surface PubMed 
    part_of chloride channel complex  
    located_in cytoplasmic vesicle membrane  
    is_active_in dendrite membrane  
    located_in dendrite membrane PubMed 
    is_active_in dendritic spine  
    is_active_in glutamatergic synapse PubMed 
    located_in inhibitory synapse PubMed 
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    is_active_in postsynapse  
    located_in postsynaptic membrane  
    is_active_in postsynaptic membrane  
    is_active_in postsynaptic specialization membrane PubMed 
    located_in postsynaptic specialization membrane PubMed 
    Items 1 - 20 of 27

    General protein information

    Preferred Names
    gamma-aminobutyric acid receptor subunit gamma-2
    Names
    GABA(A) receptor subunit gamma-2
    GABAAR subunit gamma-2
    gamma-aminobutyric acid (GABA) A receptor, gamma 2
    gamma-aminobutyric acid (GABA-A) receptor, subunit gamma 2
    gamma-aminobutyric acid A receptor, gamma 2
    gamma-aminobutyric acid type A receptor gamma 2 subunit

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001393775.1NP_001380704.1  gamma-aminobutyric acid receptor subunit gamma-2 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      CB740905, JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A0G2K2G4, Q6PW52
      Related
      ENSRNOP00000004619.3, ENSRNOT00000004619.4
      Conserved Domains (2) summary
      TIGR00860
      Location:68471
      LIC; Cation transporter family protein
      cd19000
      Location:89270
      LGIC_ECD_GABAAR_G; extracellular domain of gamma-aminobutyric acid receptor subunit gamma
    2. NM_183327.2NP_899156.1  gamma-aminobutyric acid receptor subunit gamma-2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_899156.1

      Status: VALIDATED

      Source sequence(s)
      CB740905, JAXUCZ010000010
      UniProtKB/Swiss-Prot
      P18508
      Related
      ENSRNOP00000072234.2, ENSRNOT00000082445.3
      Conserved Domains (2) summary
      TIGR00860
      Location:68463
      LIC; Cation transporter family protein
      cd19000
      Location:89270
      LGIC_ECD_GABAAR_G; extracellular domain of gamma-aminobutyric acid receptor subunit gamma

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      26876926..26965523 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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