Haus4 HAUS augmin-like complex, subunit 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Haus4provided by MGI
Official Full Name: HAUS augmin-like complex, subunit 4provided by MGI
Primary source: MGI:MGI:1261794
See related: Ensembl:ENSMUSG00000022177 AllianceGenome:MGI:1261794
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D14Ertd500e; 9430093H08Rik
Summary: Predicted to enable microtubule minus-end binding activity. Predicted to be involved in centrosome cycle and spindle assembly. Predicted to be located in centrosome and mitotic spindle microtubule. Predicted to be part of HAUS complex. Is expressed in cartilage; musculoskeletal system; and sensory organ. Orthologous to human HAUS4 (HAUS augmin like complex subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in testis adult (RPKM 20.6), genital fat pad adult (RPKM 10.1) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 C2; 14 27.83 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (54779242..54792446, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (54541785..54554989, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C14orf94 (e-PCR)
- UniSTS:278134

NoName (e-PCR)
- UniSTS:237184

AU016300 (e-PCR)
- UniSTS:180654

D14Ertd500e (e-PCR), detects polymorphism
- UniSTS:167138

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables microtubule minus-end binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in centrosome cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in centrosome cycle	ISO Inferred from Sequence Orthology more info
involved_in centrosome cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in spindle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in spindle assembly	ISO Inferred from Sequence Orthology more info
involved_in spindle assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of HAUS complex	IBA Inferred from Biological aspect of Ancestor more info
part_of HAUS complex	ISO Inferred from Sequence Orthology more info
part_of HAUS complex	ISS Inferred from Sequence or Structural Similarity more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle microtubule	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle microtubule	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: HAUS augmin-like complex subunit 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145462.2 → NP_663437.2 HAUS augmin-like complex subunit 4

See identical proteins and their annotated locations for NP_663437.2

Status: VALIDATED

Source sequence(s)

AI642699, AK079852, BB855694

Consensus CDS

CCDS27092.1

UniProtKB/Swiss-Prot

Q8BFT2, Q99KI1

Related

ENSMUSP00000022784.9, ENSMUST00000022784.9

Conserved Domains (1) summary

pfam14735
Location:126 → 360

HAUS4; HAUS augmin-like complex subunit 4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

54779242..54792446 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030247756.1 → XP_030103616.1 HAUS augmin-like complex subunit 4 isoform X2

Conserved Domains (1) summary

pfam14735
Location:1 → 210

HAUS4; HAUS augmin-like complex subunit 4
XM_006518845.5 → XP_006518908.1 HAUS augmin-like complex subunit 4 isoform X1

See identical proteins and their annotated locations for XP_006518908.1

UniProtKB/Swiss-Prot

Q8BFT2, Q99KI1

Conserved Domains (1) summary

pfam14735
Location:126 → 360

HAUS4; HAUS augmin-like complex subunit 4