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    Setsip SET like protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307947, updated on 9-Dec-2024

    Summary

    Official Symbol
    Setsipprovided by RGD
    Official Full Name
    SET like proteinprovided by RGD
    Primary source
    RGD:1307467
    See related
    EnsemblRapid:ENSRNOG00000062793 AllianceGenome:RGD:1307467
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Set; Ab1-115
    Summary
    Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in endothelial cell differentiation and positive regulation of transcription by RNA polymerase II. Predicted to be located in several cellular components, including lipid droplet; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to several human genes including SET (SET nuclear proto-oncogene). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Setsip in Genome Data Viewer
    Location:
    19q12
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (70458604..70460122)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (53561262..53562780)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (58420635..58422153)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483660 Neighboring gene signal-induced proliferation-associated 1 like 2 Neighboring gene uncharacterized LOC120098601 Neighboring gene microtubule-associated protein 10

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding  
    enables chromatin binding  
    enables chromatin binding  
    enables histone binding  
    enables protein binding PubMed 
    Component Evidence Code Pubs
    located_in chromatin  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in endoplasmic reticulum  
    located_in lipid droplet  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  
    located_in perinuclear region of cytoplasm  

    General protein information

    Preferred Names
    protein SET
    Names
    I-2PP2A
    SET nuclear oncogene
    SET nuclear proto-oncogene
    SET translocation
    TAF-I
    liver regeneration-related protein LRRGR00002
    phosphatase 2A inhibitor I2PP2A
    template-activating factor I

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012504.1NP_001012522.1  protein SET

      See identical proteins and their annotated locations for NP_001012522.1

      Status: VALIDATED

      Source sequence(s)
      AY325137, BQ782936, BU758850
      UniProtKB/TrEMBL
      A0A8I6G2K3
      Related
      ENSRNOP00000078925.1, ENSRNOT00000102684.2
      Conserved Domains (1) summary
      pfam00956
      Location:49233
      NAP; Nucleosome assembly protein (NAP)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      70458604..70460122
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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