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    MSS18 Mss18p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856253, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MSS18
    Official Full Name
    Mss18p
    Primary source
    SGD:S000006338
    Locus tag
    YPR134W
    See related
    AllianceGenome:SGD:S000006338; FungiDB:YPR134W; VEuPathDB:YPR134W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in Group I intron splicing and mitochondrial mRNA processing. Located in mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MSS18 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (798051..798857)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Spn1p Neighboring gene Tom5p Neighboring gene chromatin-binding protein CTF4 Neighboring gene Rrp9p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MSS18, a yeast nuclear gene involved in the splicing of intron aI5 beta of the mitochondrial cox1 transcript. Séraphin B, et al. EMBO J, 1988 May. PMID 2842150, Free PMC Article
    2. Mne1 is a novel component of the mitochondrial splicing apparatus responsible for processing of a COX1 group I intron in yeast. Watts T, et al. J Biol Chem, 2011 Mar 25. PMID 21257754, Free PMC Article
    3. Splicing of yeast aI5beta group I intron requires SUV3 to recycle MRS1 via mitochondrial degradosome-promoted decay of excised intron ribonucleoprotein (RNP). Turk EM, et al. J Biol Chem, 2010 Mar 19. PMID 20064926, Free PMC Article
    4. Multiple pathways influence mitochondrial inheritance in budding yeast. Frederick RL, et al. Genetics, 2008 Feb. PMID 18245340, Free PMC Article
    5. Rcf1 mediates cytochrome oxidase assembly and respirasome formation, revealing heterogeneity of the enzyme complex. Vukotic M, et al. Cell Metab, 2012 Mar 7. PMID 22342701

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. defects in Suv3p result in accumulation of stable, excised group I intron ribonucleoproteins, which result in sequestration of Mrs1p, and a concomitant reduction in splicing of aI5beta
      Title: Splicing of yeast aI5beta group I intron requires SUV3 to recycle MRS1 via mitochondrial degradosome-promoted decay of excised intron ribonucleoprotein (RNP).
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in Group I intron splicing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in Group I intron splicing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial mRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mss18p
    NP_015460.1
    • Nuclear encoded protein needed for splicing of mitochondrial intron; required for efficient splicing of mitochondrial COX1 aI5beta intron; mss18 mutations block cleavage of 5' exon - intron junction; phenotype of intronless strain suggests additional functions

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      798051..798857
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184231.1 → NP_015460.1  TPA: Mss18p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015460.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W4D1, P08593
      UniProtKB/TrEMBL
      A6ZX12, B3LK96, B5VTS0, C8ZJF7, N1P2F0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08593.1

    Gene LinkOut

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