Dagla diacylglycerol lipase, alpha [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Daglaprovided by RGD
Official Full Name: diacylglycerol lipase, alphaprovided by RGD
Primary source: RGD:1359461
See related: EnsemblRapid:ENSRNOG00000027264 AllianceGenome:RGD:1359461
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nsddr
Summary: Predicted to enable lipoprotein lipase activity and monoacylglycerol lipase activity. Predicted to be involved in several processes, including G protein-coupled glutamate receptor signaling pathway; diacylglycerol catabolic process; and retrograde trans-synaptic signaling by endocannabinoid. Predicted to act upstream of or within several processes, including cannabinoid biosynthetic process; endocannabinoid signaling pathway; and monoacylglycerol biosynthetic process. Predicted to be located in early endosome membrane; synaptic membrane; and varicosity. Predicted to be active in cytoplasm; dendrite membrane; and postsynaptic membrane. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to human DAGLA (diacylglycerol lipase alpha). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 30.5), Lung (RPKM 15.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (216315515..216372219, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (206890635..206947332, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (226297013..226353712, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CaMKII Modulates Diacylglycerol Lipase-alpha Activity in the Rat Nucleus Accumbens after Incubation of Cocaine Craving.
Title: CaMKII Modulates Diacylglycerol Lipase-α Activity in the Rat Nucleus Accumbens after Incubation of Cocaine Craving.
we showed here an integrated description of the distribution of 1,2-diacylglycerol lipase alpha in the rat forebrain
Title: Distribution of diacylglycerol lipase alpha, an endocannabinoid synthesizing enzyme, in the rat forebrain.
pharmacological inhibitors of DGLalpha have quantitatively different effects on eCB-mediated responses triggered by different stimuli, suggesting that functional, and perhaps physical, distinctions among pools of DAGLalpha exist.
Title: Endocannabinoids generated by Ca2+ or by metabotropic glutamate receptors appear to arise from different pools of diacylglycerol lipase.
Maternal deprivation induced a significant increase in DAGLalpha immunoreactivity in the rat both males and females.
Title: Early maternal deprivation induces changes on the expression of 2-AG biosynthesis and degradation enzymes in neonatal rat hippocampus.
Data show that L- and N-type calcium channel current, but not M-current inhibition by M1 muscarinic receptors requires DAG lipase activity.
Title: L- and N-current but not M-current inhibition by M1 muscarinic receptors requires DAG lipase activity.

Submit: New GeneRIF Correction

General gene information

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Markers

AU028813 (e-PCR)
- UniSTS:111961

BF400268 (e-PCR)
- UniSTS:244906

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hydrolase activity	ISO Inferred from Sequence Orthology more info
enables lipoprotein lipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monoacylglycerol lipase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in arachidonate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of arachidonate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in arachidonate metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within arachidonate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in arachidonate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cannabinoid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in diacylglycerol catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in diacylglycerol catabolic process	ISO Inferred from Sequence Orthology more info
involved_in diacylglycerol catabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within endocannabinoid signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within monoacylglycerol biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuroblast proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuroblast proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within neurogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neurogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of neuroinflammatory response	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuroinflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in retrograde trans-synaptic signaling by endocannabinoid	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde trans-synaptic signaling by endocannabinoid	ISO Inferred from Sequence Orthology more info
involved_in retrograde trans-synaptic signaling by endocannabinoid	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in dendrite membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite membrane	ISO Inferred from Sequence Orthology more info
located_in dendrite membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in dendritic spine membrane	ISO Inferred from Sequence Orthology more info
located_in dendritic spine membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in early endosome membrane	ISO Inferred from Sequence Orthology more info
located_in early endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in varicosity	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: diacylglycerol lipase-alpha

Names: DGL-alpha; neural stem cell-derived dendrite regulator; sn1-specific diacylglycerol lipase alpha

NP_001005886.1

EC 3.1.1.116

XP_017444750.1

EC 3.1.1.116

XP_038935698.1

EC 3.1.1.116

XP_038935700.1

EC 3.1.1.116

XP_038935707.1

EC 3.1.1.116

XP_038935713.1

EC 3.1.1.116

XP_063120516.1

EC 3.1.1.116

XP_063120519.1

EC 3.1.1.116

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005886.2 → NP_001005886.1 diacylglycerol lipase-alpha

See identical proteins and their annotated locations for NP_001005886.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q5YLM1

Related

ENSRNOP00000033416.2, ENSRNOT00000037624.4

Conserved Domains (1) summary

cd00519
Location:288 → 529

Lipase_3; Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

216315515..216372219 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017589261.3 → XP_017444750.1 diacylglycerol lipase-alpha isoform X1

UniProtKB/Swiss-Prot

Q5YLM1

Conserved Domains (1) summary

cd00519
Location:288 → 529

Lipase_3; Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of ...
XM_039079772.2 → XP_038935700.1 diacylglycerol lipase-alpha isoform X1

UniProtKB/Swiss-Prot

Q5YLM1

Conserved Domains (1) summary

cd00519
Location:288 → 529

Lipase_3; Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of ...
XM_039079770.2 → XP_038935698.1 diacylglycerol lipase-alpha isoform X1

UniProtKB/Swiss-Prot

Q5YLM1

Conserved Domains (1) summary

cd00519
Location:288 → 529

Lipase_3; Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of ...
XM_039079779.2 → XP_038935707.1 diacylglycerol lipase-alpha isoform X2

UniProtKB/TrEMBL

A6I016

Conserved Domains (1) summary

cd00519
Location:3 → 244

Lipase_3; Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of ...
XM_039079785.2 → XP_038935713.1 diacylglycerol lipase-alpha isoform X3

Conserved Domains (1) summary

cd00519
Location:288 → 529

Lipase_3; Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of ...
XM_063264449.1 → XP_063120519.1 diacylglycerol lipase-alpha isoform X5
XM_063264446.1 → XP_063120516.1 diacylglycerol lipase-alpha isoform X4