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    ERG2 C-8 sterol isomerase ERG2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855242, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ERG2
    Official Full Name
    C-8 sterol isomerase ERG2
    Primary source
    SGD:S000004815
    Locus tag
    YMR202W
    See related
    AllianceGenome:SGD:S000004815; FungiDB:YMR202W; VEuPathDB:YMR202W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    END11
    Summary
    Enables C-8 sterol isomerase activity. Involved in ergosterol biosynthetic process. Located in endoplasmic reticulum. Used to study amyotrophic lateral sclerosis type 16. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 16 and autosomal recessive distal hereditary motor neuronopathy 2. Orthologous to human SIGMAR1 (sigma non-opioid intracellular receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ERG2 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (667537..668205)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene DNA repair protein RAD14 Neighboring gene ncRNA Neighboring gene Tom40p Neighboring gene Inp1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nucleotide sequence of the gene encoding yeast C-8 sterol isomerase. Arthington BA, et al. Gene, 1991 Oct 30. PMID 1743517
    2. Cloning and disruption of the yeast C-8 sterol isomerase gene. Ashman WH, et al. Lipids, 1991 Aug. PMID 1779709
    3. Abnormal sterol-induced cell wall glucan deficiency in yeast is due to impaired glucan synthase transport to the plasma membrane. Gutierrez-Armijos R, et al. Biochem J, 2020 Oct 23. PMID 33094814
    4. Yeast sterol C8-C7 isomerase: identification and characterization of a high-affinity binding site for enzyme inhibitors. Moebius FF, et al. Biochemistry, 1996 Dec 24. PMID 8988026
    5. Both the immunosuppressant SR31747 and the antiestrogen tamoxifen bind to an emopamil-insensitive site of mammalian Delta8-Delta7 sterol isomerase. Paul R, et al. J Pharmacol Exp Ther, 1998 Jun. PMID 9618436

    See all (130) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Thermostabilization of Membrane Proteins by Consensus Mutation: A Case Study for a Fungal Delta8-7 Sterol Isomerase.
      Title: Thermostabilization of Membrane Proteins by Consensus Mutation: A Case Study for a Fungal Δ8-7 Sterol Isomerase.
    2. this study shows that MiR-150-5p regulates EGR2 to promote the development of chronic rhinosinusitis
      Title: MiR-150-5p regulates EGR2 to promote the development of chronic rhinosinusitis via the DC-Th axis.
    3. Here, it is shown that the deletion in ERG2, which encodes sterol C8-C7 isomerase (the next enzymatic step after Erg6), promotes the vacuolar degradation of Tat2.
      Title: Sorting defects of the tryptophan permease Tat2 in an erg2 yeast mutant.
    4. Overexpression of ERG6 and ERG2 led to an increased ergosterol level.
      Title: [Regulation role of sterol C-24 methyltransferase and sterol C-8 isomerase in the ergosterol biosynthesis of Saccharomyces cerevisiae].
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables C-8 sterol isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables C-8 sterol isomerase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ergosterol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ergosterol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    C-8 sterol isomerase ERG2
    NP_013929.1
    • C-8 sterol isomerase; catalyzes isomerization of delta-8 double bond to delta-7 position at an intermediate step in ergosterol biosynthesis; transcriptionally down-regulated when ergosterol is in excess; mutation is functionally complemented by human EBP

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      667537..668205
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182709.1 → NP_013929.1  TPA: C-8 sterol isomerase ERG2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013929.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W027, P32352
      UniProtKB/TrEMBL
      A6ZMR4, B3LM90, C7GRE9, C8ZF67, G2WKQ8, N1NXJ8, S4VL25
      Conserved Domains (1) summary
      pfam04622
      Location:15 → 216
      ERG2_Sigma1R; ERG2 and Sigma1 receptor like protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32352.1

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