Jmjd8 jumonji domain containing 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Jmjd8provided by MGI
Official Full Name: jumonji domain containing 8provided by MGI
Primary source: MGI:MGI:1919356
See related: Ensembl:ENSMUSG00000025736 AllianceGenome:MGI:1919356
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2610003J06Rik
Summary: Predicted to enable cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including positive regulation of canonical NF-kappaB signal transduction; positive regulation of sprouting angiogenesis; and regulation of pyruvate kinase activity. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in nucleus. Is expressed in brain; gonad; lung; metanephros; and submandibular gland. Orthologous to human JMJD8 (jumonji domain containing 8). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 71.8), kidney adult (RPKM 66.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 12.92 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (26048017..26050817)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (25829043..25831843)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

JMJD8 regulates neuropathic pain by affecting spinal cord astrocyte differentiation.
Title: JMJD8 regulates neuropathic pain by affecting spinal cord astrocyte differentiation.
ER-localized JmjC domain-containing protein JMJD8 targets STING to promote immune evasion and tumor growth in breast cancer.
Title: ER-localized JmjC domain-containing protein JMJD8 targets STING to promote immune evasion and tumor growth in breast cancer.
Jmjd8 is upregulated during endothelial differentiation and regulates endothelial sprouting and metabolism by interacting with pyruvate kinase M2.
Title: JMJD8 Regulates Angiogenic Sprouting and Cellular Metabolism by Interacting With Pyruvate Kinase M2 in Endothelial Cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation
Targeted (2)

General gene information

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Markers

19.MMHAP26FLG1.seq (e-PCR)
- UniSTS:123423

Dmrt1 (e-PCR), detects polymorphism
- UniSTS:516703

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sprouting angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of glycolytic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of glycolytic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of pyruvate kinase activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of pyruvate kinase activity	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum lumen	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum lumen	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: jmjC domain-containing protein 8

Names: jumonji domain-containing protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028101.5 → NP_082377.3 jmjC domain-containing protein 8 precursor

Status: VALIDATED

Source sequence(s)

AK155810, BE982271

Consensus CDS

CCDS28532.2

UniProtKB/Swiss-Prot

A0A3B2W707, Q3TA59, Q3U1Q1, Q91XD9, Q9D0L5

UniProtKB/TrEMBL

A0A9L6H220

Related

ENSMUSP00000026832.8, ENSMUST00000026832.14

Conserved Domains (1) summary

cl21464
Location:59 → 253

cupin_like; Conserved domain found in cupin and related proteins