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    Irgc immunity related GTPase cinema [ Mus musculus (house mouse) ]

    Gene ID: 210145, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Irgcprovided by MGI
    Official Full Name
    immunity related GTPase cinemaprovided by MGI
    Primary source
    MGI:MGI:2685948
    See related
    Ensembl:ENSMUSG00000062028 AllianceGenome:MGI:2685948
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm474; Ifgge; Iigp5; Irgc1; Gm1102; F630044M05Rik
    Summary
    Predicted to enable GTP binding activity and membrane scission GTPase motor activity. Involved in positive regulation of flagellated sperm motility. Located in lipid droplet and sperm mitochondrial sheath. Orthologous to human IRGC (immunity related GTPase cinema). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 598.9) See more
    Orthologs
    human all
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    Genomic context

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    See Irgc in Genome Data Viewer
    Location:
    7 A3; 7 10.74 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (24131344..24145107, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (24431919..24445682, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:25164989-25165185 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:25179546-25179699 Neighboring gene SMG9 nonsense mediated mRNA decay factor Neighboring gene STARR-seq mESC enhancer starr_18260 Neighboring gene predicted gene, 36159 Neighboring gene predicted gene, 57507 Neighboring gene STARR-seq mESC enhancer starr_18263 Neighboring gene predicted gene, 53353

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. IRGC1, a testis-enriched immunity related GTPase, is important for fibrous sheath integrity and sperm motility in mice. Kaneda Y, et al. Dev Biol, 2022 Aug. PMID 35618043, Free PMC Article
    2. The immunity-related GTPase IRGC mediates interaction between lipid droplets and mitochondria to facilitate sperm motility. Li J, et al. FEBS Lett, 2023 Jun. PMID 37195149
    3. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IRGC1, a testis-enriched immunity related GTPase, is important for fibrous sheath integrity and sperm motility in mice.
      Title: IRGC1, a testis-enriched immunity related GTPase, is important for fibrous sheath integrity and sperm motility in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables membrane scission GTPase motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm mitochondrial sheath IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sperm mitochondrial sheath ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    interferon-inducible GTPase 5
    Names
    immunity related GTPase cinema 1
    immunity-related GTPase family, cinema 1
    interferon inducible GTPase family member 5
    interferon-gamma-inducible GTPase Ifgge protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358033.1 → NP_001344962.1  interferon-inducible GTPase 5

      Status: VALIDATED

      Source sequence(s)
      AC159140
      Consensus CDS
      CCDS39831.1
      UniProtKB/TrEMBL
      D3Z720
      Related
      ENSMUSP00000104072.3, ENSMUST00000080594.8
      Conserved Domains (2) summary
      cd04104
      Location:52 → 248
      p47_IIGP_like; p47 GTPase family includes IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1
      pfam03193
      Location:9 → 74
      RsgA_GTPase; RsgA GTPase

    2. NM_001358034.1 → NP_001344963.1  interferon-inducible GTPase 5

      Status: VALIDATED

      Source sequence(s)
      AC159140
      Consensus CDS
      CCDS39831.1
      UniProtKB/TrEMBL
      D3Z720
      Conserved Domains (2) summary
      cd04104
      Location:52 → 248
      p47_IIGP_like; p47 GTPase family includes IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1
      pfam03193
      Location:9 → 74
      RsgA_GTPase; RsgA GTPase

    3. NM_199013.2 → NP_950178.2  interferon-inducible GTPase 5

      See identical proteins and their annotated locations for NP_950178.2

      Status: VALIDATED

      Source sequence(s)
      AC159140, AC161166
      Consensus CDS
      CCDS39831.1
      UniProtKB/TrEMBL
      D3Z720
      Related
      ENSMUSP00000145975.2, ENSMUST00000205776.2
      Conserved Domains (2) summary
      cd04104
      Location:52 → 248
      p47_IIGP_like; p47 GTPase family includes IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1
      pfam03193
      Location:9 → 74
      RsgA_GTPase; RsgA GTPase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      24131344..24145107 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C262.1 GenPept UniProtKB/Swiss-Prot:Q8C262

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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