Nrtn neurturin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nrtnprovided by MGI
Official Full Name: neurturinprovided by MGI
Primary source: MGI:MGI:108417
See related: Ensembl:ENSMUSG00000039481 AllianceGenome:MGI:108417
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NTN
Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein signals through the RET receptor tyrosine kinase and a GPI-linked coreceptor, and promotes survival of neuronal populations. Homozygous knockout mice for this gene exhibit defects in the development of the retina and enteric nervous system, and reduced cholinergic innervation of the heart and lacrimal glands. [provided by RefSeq, Aug 2016]
Expression: Broad expression in ovary adult (RPKM 87.5), stomach adult (RPKM 66.3) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 D; 17 29.49 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (57058323..57064548, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (56751323..56757548, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Muscle-secreted neurturin couples myofiber oxidative metabolism and slow motor neuron identity.
Title: Muscle-secreted neurturin couples myofiber oxidative metabolism and slow motor neuron identity.
These results indicate that NRTN contributes to an increase in the epidermal density of nonpeptidergic nerves in the imiquimod-induced psoriasis model, and this increase may be a factor in chronic itch.
Title: Role of neurturin in spontaneous itch and increased nonpeptidergic intraepidermal fiber density in a mouse model of psoriasis.
NRTN causes presynaptic and postsynaptic restoration of the nigrostriatal dopaminergic system after a 6-OHDA-induced chronic lesion.
Title: Neurturin overexpression in dopaminergic neurons induces presynaptic and postsynaptic structural changes in rats with chronic 6-hydroxydopamine lesion.
identified IFNg, Neurturin (Nrtn), and glial-derived neurotrophic factor (GDNF) as ligands with unexpected roles in promoting neurogenic differentiation of Neural Precursor Cells in vivo.
Title: Proneurogenic Ligands Defined by Modeling Developing Cortex Growth Factor Communication Networks.
These results demonstrate the potential roles of different functional groups of sensory neurons in the behavioral changes observed in mice overexpressing cutaneous neurturin and highlight the importance of neurturin in regulating cutaneous afferent response properties.
Title: Cutaneous neurturin overexpression alters mechanical, thermal, and cold responsiveness in physiologically identified primary afferents.
Deletion of neurturin impairs cholinergic innervation of the heart and the baroreflex response in early postnatal development.
Title: Deletion of neurturin impairs development of cholinergic nerves and heart rate control in postnatal mouse hearts.
Our findings support the hypothesis that NTN could modulate the allergic inflammation in different mouse asthma models.
Title: Neurturin influences inflammatory responses and airway remodeling in different mouse asthma models.
NTN inactivation enhances androgen sensitivity in reproductive and neuroendocrine tissues.
Title: Evidence for increased tissue androgen sensitivity in neurturin knockout mice.
the expression level of NRTN in the skin modulates gene expression in cutaneous sensory afferents and behavioral sensitivity to thermal, chemical, and mechanical stimuli.
Title: Neurturin overexpression in skin enhances expression of TRPM8 in cutaneous sensory neurons and leads to behavioral sensitivity to cool and menthol.
Findings provide evidence for a dampening role of NTN on allergic inflammation and AHR in a murine model of asthma.
Title: Increased Th2 cytokine secretion, eosinophilic airway inflammation, and airway hyperresponsiveness in neurturin-deficient mice.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Nrtn (e-PCR), detects polymorphism
- UniSTS:256690

Nrtn (e-PCR), detects polymorphism
- UniSTS:507103

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables glial cell-derived neurotrophic factor receptor binding	IEA Inferred from Electronic Annotation more info
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IDA Inferred from Direct Assay more info	PubMed
enables growth factor activity	ISO Inferred from Sequence Orthology more info
enables heparan sulfate binding	ISO Inferred from Sequence Orthology more info
enables heparan sulfate binding	ISS Inferred from Sequence or Structural Similarity more info
enables receptor tyrosine kinase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell surface receptor signaling pathway via STAT	IDA Inferred from Direct Assay more info	PubMed
involved_in glial cell-derived neurotrophic factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in glial cell-derived neurotrophic factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nerve development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural crest cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron projection development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
located_in axon	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: neurturin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008738.4 → NP_032764.1 neurturin preproprotein

See identical proteins and their annotated locations for NP_032764.1

Status: VALIDATED

Source sequence(s)

CT010491

Consensus CDS

CCDS28913.1

UniProtKB/Swiss-Prot

P97463

Related

ENSMUSP00000046512.6, ENSMUST00000044752.6

Conserved Domains (1) summary

cd19383
Location:101 → 195

TGF_beta_Neurturin; transforming growth factor beta (TGF-beta) like domain found in Neurturin and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

57058323..57064548 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006523801.3 → XP_006523864.1 neurturin isoform X1

See identical proteins and their annotated locations for XP_006523864.1

UniProtKB/Swiss-Prot

P97463

Conserved Domains (1) summary

cd19383
Location:101 → 195

TGF_beta_Neurturin; transforming growth factor beta (TGF-beta) like domain found in Neurturin and similar proteins