Il17rd interleukin 17 receptor D [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il17rdprovided by MGI
Official Full Name: interleukin 17 receptor Dprovided by MGI
Primary source: MGI:MGI:2159727
See related: Ensembl:ENSMUSG00000040717 AllianceGenome:MGI:2159727
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sef; mSef; Sef-S; IL-17RD; 2810004A10Rik
Summary: Predicted to enable interleukin-17 receptor activity. Involved in negative regulation of epithelial to mesenchymal transition and negative regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in Golgi apparatus and nucleoplasm. Is expressed in several structures, including alimentary system; brain; branchial arch; extraembryonic component; and sensory organ. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 18 with or without anosmia. Orthologous to human IL17RD (interleukin 17 receptor D). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in limb E14.5 (RPKM 5.6), lung adult (RPKM 4.4) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 A3; 14 16.09 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (26760990..26829243)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (27038964..27107286)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Endothelial IL17RD promotes Western diet-induced aortic myeloid cell infiltration.
Title: Endothelial IL17RD promotes Western diet-induced aortic myeloid cell infiltration.
A shedding soluble form of interleukin-17 receptor D exacerbates collagen-induced arthritis through facilitating TNF-alpha-dependent receptor clustering.
Title: A shedding soluble form of interleukin-17 receptor D exacerbates collagen-induced arthritis through facilitating TNF-α-dependent receptor clustering.
IL-17RD/sef exacerbates experimental mouse colitis and inflammation-associated tumorigenesis by regulating the proportion of T cell subsets.
Title: IL-17RD/sef exacerbates experimental mouse colitis and inflammation-associated tumorigenesis by regulating the proportion of T cell subsets.
Loss of interleukin-17 receptor D promotes chronic inflammation-associated tumorigenesis.
Title: Loss of interleukin-17 receptor D promotes chronic inflammation-associated tumorigenesis.
Deficiency of IL-17RD expression in cells leads to enhanced pro-inflammatory signalling and gene expression in response to TLR stimulation, and Il17rd(-/-) mice are more susceptible to TLR-induced septic shock.
Title: Orphan receptor IL-17RD regulates Toll-like receptor signalling via SEFIR/TIR interactions.
Demonstrate SEF expression in a healthy ovary during folliculogenesis and suggest hormonal regulation of its expression may be an important factor involved in intra-ovarian control mechanisms.
Title: Expression and regulation of the tumor suppressor, SEF, during folliculogenesis in humans and mice.
these studies indicate that Sef has specific roles in osteoblast and osteoclast lineages and that its absence results in increased osteoblast and osteoclast activity with a net increase in cortical bone mass.
Title: Deficiency of Sef is associated with increased postnatal cortical bone mass by regulating Runx2 activity.
Orphan receptor IL-17RD tunes IL-17A signalling and is required for neutrophilia.
Title: Orphan receptor IL-17RD tunes IL-17A signalling and is required for neutrophilia.
Since expression of IL-17 is elevated in 3-month-old MRL/lpr mice, we suggest that it plays a role in the pathophysiology of autoimmune dacryoadenitis in these mice.
Title: Expression of interleukin-17 in autoimmune dacryoadenitis in MRL/lpr mice.
Over-expressing Sef specifically in the lens of transgenic mice led to impaired lens and eye development that resulted in microphthalmia.
Title: Sef is a negative regulator of fiber cell differentiation in the ocular lens.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237138

NoName (e-PCR)
- UniSTS:237144

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

AI428510 (e-PCR)
- UniSTS:180619

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables interleukin-17 receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-17 receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cytokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of epithelial to mesenchymal transition	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: interleukin-17 receptor D

Names: IL-17 receptor D; interleukin-17 receptor-like protein; sef homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001411765.1 → NP_001398694.1 interleukin-17 receptor D isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC124603, AC125152
NM_134437.4 → NP_602319.1 interleukin-17 receptor D isoform 1 precursor

See identical proteins and their annotated locations for NP_602319.1

Status: VALIDATED

Source sequence(s)

AC124603, AC125152

Consensus CDS

CCDS26885.1

UniProtKB/Swiss-Prot

B2RRY7, Q8JZL1, Q8K447, Q8R5J8

Related

ENSMUSP00000036076.4, ENSMUST00000035336.5

Conserved Domains (2) summary

pfam08357
Location:356 → 511

SEFIR; SEFIR domain

pfam16742
Location:48 → 169

IL17R_D_N; N-terminus of interleukin 17 receptor D

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

26760990..26829243

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006518668.2 → XP_006518731.1 interleukin-17 receptor D isoform X2

UniProtKB/TrEMBL

Q3V0D5

Related

ENSMUSP00000153543.2, ENSMUST00000225146.2

Conserved Domains (2) summary

pfam08357
Location:212 → 367

SEFIR; SEFIR domain

pfam16742
Location:1 → 25

IL17R_D_N; N-terminus of interleukin 17 receptor D