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    KAR1 Kar1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855533, updated on 9-Dec-2024

    Summary

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    Official Symbol
    KAR1
    Official Full Name
    Kar1p
    Primary source
    SGD:S000005132
    Locus tag
    YNL188W
    See related
    AllianceGenome:SGD:S000005132; FungiDB:YNL188W; VEuPathDB:YNL188W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in karyogamy involved in conjugation with cellular fusion and spindle pole body duplication. Located in half bridge of spindle pole body. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See KAR1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (286308..287609)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene karyopherin alpha Neighboring gene Swt21p Neighboring gene ubiquitin-specific protease UBP10

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Asymmetric mitotic segregation of the yeast spindle pole body. Vallen EA, et al. Cell, 1992 May 1. PMID 1581964
    2. KAR1, a gene required for function of both intranuclear and extranuclear microtubules in yeast. Rose MD, et al. Cell, 1987 Mar 27. PMID 3030557
    3. Bud selection and apoptosis-like degradation of nuclei in yeast heterokaryons: a KAR1 effect. Nevzglyadova OV, et al. Mol Genet Genomics, 2005 Nov. PMID 16160851
    4. The role of gene dosage in budding yeast centrosome scaling and spontaneous diploidization. Chen J, et al. PLoS Genet, 2020 Dec. PMID 33332348, Free PMC Article
    5. kem mutations affect nuclear fusion in Saccharomyces cerevisiae. Kim J, et al. Genetics, 1990 Dec. PMID 2076815, Free PMC Article

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Kar1 binding is restricted to Sfi1-C-terminal and Sfi1 C-terminal centrin-binding repeats, and centrin and Kar1 provide cross-links, while Sfi1-C-terminal stabilizes the bridge and ensures timely spindle pole body separation.
      Title: Kar1 binding to Sfi1 C-terminal regions anchors the SPB bridge to the nuclear envelope.
    2. kar1 has a role in nuclear congression and nuclear fusion
      Title: Bud selection and apoptosis-like degradation of nuclei in yeast heterokaryons: a KAR1 effect.
    3. Functions of Nud1p are connected to the ability of Spc72p to bind to the outer plaque and half-bridge (via Kar1p) of the SPB.
      Title: Nud1p, the yeast homolog of Centriolin, regulates spindle pole body inheritance in meiosis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in karyogamy involved in conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spindle pole body duplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    located_in half bridge of spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle pole body IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Kar1p
    NP_014211.1
    • Protein involved in karyogamy and spindle pole body duplication; involved in karyogamy during mating; involved in centrosome separation and duplication during mitosis; localizes to the half-bridge of the spindle pole body; interacts with Spc72p during karyogamy; also interacts with Cdc31p; essential gene

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      286308..287609
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183026.1 → NP_014211.1  TPA: Kar1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014211.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0Z9, E9P8Y4, P11927
      UniProtKB/TrEMBL
      A6ZRP9, B3LP37, B5VQM1, C8ZG42, N1NXA7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P11927.2

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