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    IMA2 oligo-1,6-glucosidase IMA2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854008, updated on 9-Dec-2024

    Summary

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    Official Symbol
    IMA2
    Official Full Name
    oligo-1,6-glucosidase IMA2
    Primary source
    SGD:S000005517
    Locus tag
    YOL157C
    See related
    AllianceGenome:SGD:S000005517; FungiDB:YOL157C; VEuPathDB:YOL157C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables oligo-1,6-glucosidase activity and sucrose alpha-glucosidase activity. Involved in disaccharide catabolic process. Human ortholog(s) of this gene implicated in cystinuria. Orthologous to human SLC3A1 (solute carrier family 3 member 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See IMA2 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (22525..24294, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Css3p Neighboring gene Enb1p Neighboring gene hexose transporter HXT11 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Similarities and differences in the biochemical and enzymological properties of the four isomaltases from Saccharomyces cerevisiae. Deng X, et al. FEBS Open Bio, 2014. PMID 24649402, Free PMC Article
    2. Discovery of a novel family of alpha-glucosidase IMA genes in yeast Saccharomyces cerevisiae. Naumoff DG, et al. Dokl Biochem Biophys, 2010 May-Jun. PMID 20886742
    3. Different levels of catabolite repression optimize growth in stable and variable environments. New AM, et al. PLoS Biol, 2014 Jan. PMID 24453942, Free PMC Article
    4. Inhibition kinetics of flavonoids on yeast α-glucosidase merged with docking simulations. Xu H. Protein Pept Lett, 2010 Oct. PMID 20518737
    5. Inhibition of three selected beverage extracts on alpha-glucosidase and rapid identification of their active compounds using HPLC-DAD-MS/MS and biochemical detection. Li DQ, et al. J Agric Food Chem, 2010 Jun 9. PMID 20443596

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables alpha-1,4-glucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-amylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucan 1,4-alpha-maltotriohydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oligo-1,6-glucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oligo-1,6-glucosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oligo-1,6-glucosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oligo-1,6-glucosidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables sucrose alpha-glucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sucrose alpha-glucosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in disaccharide catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in disaccharide catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in maltose catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maltose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sucrose catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    oligo-1,6-glucosidase IMA2
    NP_014485.1
    • Isomaltase (alpha-1,6-glucosidase/alpha-methylglucosidase); preferred specificity for isomaltose, alpha-methylglucoside, and palatinose, but also exhibits alpha-1,2 glucosidase activity on sucrose and kojibiose, and can cleave the 1,3-alpha linkage of nigerose and turanose and the alpha-1,5 linkage of leucrose in vitro; not required for isomaltose utilization, but Ima2p overexpression allows the ima1 null mutant to grow on isomaltose

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      22525..24294 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183410.1 → NP_014485.1  TPA: oligo-1,6-glucosidase IMA2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014485.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1R3, Q08295
      UniProtKB/TrEMBL
      A6ZPM1, B3LIR3, C8ZB00, E1AFY7, G2WM79
      Conserved Domains (2) summary
      cd11333
      Location:16 → 503
      AmyAc_SI_OligoGlu_DGase; Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins
      pfam16657
      Location:514 → 585
      Malt_amylase_C; Maltogenic Amylase, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08295.1

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