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    POA1 ADP-ribose 1''-phosphate phosphatase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852310, updated on 9-Dec-2024

    Summary

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    Official Symbol
    POA1
    Official Full Name
    ADP-ribose 1''-phosphate phosphatase
    Primary source
    SGD:S000000226
    Locus tag
    YBR022W
    See related
    AllianceGenome:SGD:S000000226; FungiDB:YBR022W; VEuPathDB:YBR022W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ADP-ribosyl-[dinitrogen reductase] hydrolase activity and phosphatase activity. Predicted to be involved in DNA damage response and purine nucleoside metabolic process. Predicted to be active in nucleoplasm. Orthologous to human OARD1 (O-acyl-ADP-ribose deacylase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See POA1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (283738..284271)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene galactokinase Neighboring gene uracil permease Neighboring gene chitin synthase CHS3 Neighboring gene putative thioredoxin peroxidase SCO2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A biochemical genomics approach for identifying genes by the activity of their products. Martzen MR, et al. Science, 1999 Nov 5. PMID 10550052
    2. A highly specific phosphatase that acts on ADP-ribose 1''-phosphate, a metabolite of tRNA splicing in Saccharomyces cerevisiae. Shull NP, et al. Nucleic Acids Res, 2005. PMID 15684411, Free PMC Article
    3. A family of macrodomain proteins reverses cellular mono-ADP-ribosylation. Jankevicius G, et al. Nat Struct Mol Biol, 2013 Apr. PMID 23474712, Free PMC Article
    4. The macro domain is an ADP-ribose binding module. Karras GI, et al. EMBO J, 2005 Jun 1. PMID 15902274, Free PMC Article
    5. Integrating high-throughput genetic interaction mapping and high-content screening to explore yeast spindle morphogenesis. Vizeacoumar FJ, et al. J Cell Biol, 2010 Jan 11. PMID 20065090, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of POA1 as a phosphatase with activity on ADP-ribose 1''-phosphate.
      Title: A highly specific phosphatase that acts on ADP-ribose 1''-phosphate, a metabolite of tRNA splicing in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ADP-ribosyl-[dinitrogen reductase] hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ADP-ribosyl-[dinitrogen reductase] hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in purine nucleoside metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA splicing, via endonucleolytic cleavage and ligation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ADP-ribose 1''-phosphate phosphatase
    NP_009578.1
    • Phosphatase that is highly specific for ADP-ribose 1''-phosphate; a tRNA splicing metabolite; may have a role in regulation of tRNA splicing

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      283738..284271
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178370.1 → NP_009578.1  TPA: ADP-ribose 1''-phosphate phosphatase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009578.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZKW8, D6VQ24, P38218
      UniProtKB/TrEMBL
      B3LNB9, B5VDZ1, C7GM30, C8Z416, N1P6E4
      Conserved Domains (1) summary
      COG2110
      Location:1 → 174
      YmdB; O-acetyl-ADP-ribose deacetylase (regulator of RNase III), contains Macro domain [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38218.1

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