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    Cdk17 cyclin dependent kinase 17 [ Mus musculus (house mouse) ]

    Gene ID: 237459, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cdk17provided by MGI
    Official Full Name
    cyclin dependent kinase 17provided by MGI
    Primary source
    MGI:MGI:97517
    See related
    Ensembl:ENSMUSG00000020015 AllianceGenome:MGI:97517
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pctk2; 6430598J10Rik
    Summary
    Predicted to enable cyclin-dependent protein serine/threonine kinase activity. Predicted to be involved in regulation of cell cycle phase transition. Predicted to be active in cytoplasm and nucleus. Is expressed in central nervous system; inner ear; and retina. Orthologous to human CDK17 (cyclin dependent kinase 17). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in frontal lobe adult (RPKM 15.4), cortex adult (RPKM 13.0) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cdk17 in Genome Data Viewer
    Location:
    10 C2; 10 47.89 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (92996492..93086956)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (93160876..93251094)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40740 Neighboring gene predicted gene, 40741 Neighboring gene STARR-positive B cell enhancer mm9_chr10:92631736-92632037 Neighboring gene microRNA 1931 Neighboring gene STARR-seq mESC enhancer starr_27570 Neighboring gene STARR-seq mESC enhancer starr_27572 Neighboring gene STARR-seq mESC enhancer starr_27573 Neighboring gene ELK3, member of ETS oncogene family Neighboring gene predicted gene, 32604 Neighboring gene predicted gene, 32551

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family. Okuda T, et al. Oncogene, 1992 Nov. PMID 1437147
    2. ik3-1/Cables is associated with Trap and Pctaire2. Yamochi T, et al. Biochem Biophys Res Commun, 2001 Sep 7. PMID 11527406
    3. The expression of ELK transcription factors in adult DRG: Novel isoforms, antisense transcripts and upregulation by nerve damage. Kerr N, et al. Mol Cell Neurosci, 2010 Jun. PMID 20304071, Free PMC Article
    4. Myocardin-related transcription factors regulate the Cdk5/Pctaire1 kinase cascade to control neurite outgrowth, neuronal migration and brain development. Mokalled MH, et al. Development, 2010 Jul. PMID 20534669, Free PMC Article
    5. The Role of CDKs and CDKIs in Murine Development. Campbell GJ, et al. Int J Mol Sci, 2020 Jul 28. PMID 32731332, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC25109

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell cycle phase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-dependent kinase 17
    Names
    PCTAIRE-motif protein kinase 2
    Pctaire2
    cell division protein kinase 17
    serine/threonine-protein kinase PCTAIRE-2
    NP_666351.2
    XP_006513689.1
    XP_006513690.1
    XP_011241749.1
    XP_030100944.1
    XP_030100945.1
    XP_036011671.1
    XP_036011672.1
    XP_036011673.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_146239.2 → NP_666351.2  cyclin-dependent kinase 17

      See identical proteins and their annotated locations for NP_666351.2

      Status: VALIDATED

      Source sequence(s)
      BB085519, BC064815, BQ442862, BU841444, BY130550, CD350146, CJ117086, CX242491, DV646930
      Consensus CDS
      CCDS48670.1
      UniProtKB/Swiss-Prot
      Q8K0D0
      UniProtKB/TrEMBL
      A0A1L1SUS7
      Related
      ENSMUSP00000070355.8, ENSMUST00000069965.9
      Conserved Domains (1) summary
      cd07872
      Location:185 → 493
      STKc_PCTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      92996492..93086956
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155778.1 → XP_036011671.1  cyclin-dependent kinase 17 isoform X4

      UniProtKB/TrEMBL
      A0A1L1SUS7
      Related
      ENSMUSP00000150873.2, ENSMUST00000215286.2
      Conserved Domains (1) summary
      cd07872
      Location:185 → 493
      STKc_PCTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase

    2. XM_030245085.1 → XP_030100945.1  cyclin-dependent kinase 17 isoform X5

      UniProtKB/TrEMBL
      A0A1L1SUS7
      Conserved Domains (1) summary
      cd07872
      Location:101 → 409
      STKc_PCTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase

    3. XM_011243447.3 → XP_011241749.1  cyclin-dependent kinase 17 isoform X3

      See identical proteins and their annotated locations for XP_011241749.1

      UniProtKB/Swiss-Prot
      Q8K0D0
      UniProtKB/TrEMBL
      A0A1L1SUS7
      Conserved Domains (1) summary
      cd07872
      Location:185 → 493
      STKc_PCTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase

    4. XM_006513627.4 → XP_006513690.1  cyclin-dependent kinase 17 isoform X3

      See identical proteins and their annotated locations for XP_006513690.1

      UniProtKB/Swiss-Prot
      Q8K0D0
      UniProtKB/TrEMBL
      A0A1L1SUS7
      Conserved Domains (1) summary
      cd07872
      Location:185 → 493
      STKc_PCTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase

    5. XM_030245084.2 → XP_030100944.1  cyclin-dependent kinase 17 isoform X2

      UniProtKB/TrEMBL
      A0A1L1SUS7
      Conserved Domains (1) summary
      cd07872
      Location:201 → 509
      STKc_PCTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase

    6. XM_006513626.3 → XP_006513689.1  cyclin-dependent kinase 17 isoform X1

      UniProtKB/TrEMBL
      A0A1L1SUS7
      Conserved Domains (1) summary
      cd07872
      Location:201 → 509
      STKc_PCTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase

    7. XM_036155780.1 → XP_036011673.1  cyclin-dependent kinase 17 isoform X6

      UniProtKB/TrEMBL
      A0A1L1SUS7, I6L9D3
      Conserved Domains (1) summary
      cd07872
      Location:101 → 409
      STKc_PCTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase

    8. XM_036155779.1 → XP_036011672.1  cyclin-dependent kinase 17 isoform X5

      UniProtKB/TrEMBL
      A0A1L1SUS7
      Conserved Domains (1) summary
      cd07872
      Location:101 → 409
      STKc_PCTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase

    RNA

    1. XR_003948686.1 RNA Sequence

    2. XR_003948687.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K0D0.2 GenPept UniProtKB/Swiss-Prot:Q8K0D0

    Gene LinkOut

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