Gstt3 glutathione S-transferase, theta 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gstt3provided by MGI
Official Full Name: glutathione S-transferase, theta 3provided by MGI
Primary source: MGI:MGI:2143526
See related: Ensembl:ENSMUSG00000001665 AllianceGenome:MGI:2143526
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables glutathione transferase activity. Acts upstream of or within glutathione metabolic process. Predicted to be active in cytoplasm. Is expressed in several structures, including gut; metatarsal bone; olfactory epithelium; submandibular gland primordium; and urinary system. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in liver adult (RPKM 70.4), bladder adult (RPKM 44.4) and 16 other tissues See more
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Genomic context

Location:: 10 C1; 10 38.58 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (75609951..75617256, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (75774117..75781422, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification and characterization of GSTT3 [GSTT3]
Title: Identification and characterization of GSTT3, a third murine Theta class glutathione transferase.

Submit: New GeneRIF Correction

General gene information

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Markers

D10Jhu69 (e-PCR), detects polymorphism
- UniSTS:158723

D10Mit158 (e-PCR), detects polymorphism
- UniSTS:126062

AI118089 (e-PCR)
- UniSTS:185838

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in glutathione metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glutathione metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glutathione S-transferase theta-3

NP_001333452.1

EC 2.5.1.18

NP_598755.1

EC 2.5.1.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001346523.1 → NP_001333452.1 glutathione S-transferase theta-3 isoform 2

Status: VALIDATED

Source sequence(s)

AC142499, AK138669, BY232658, CX204823

Consensus CDS

CCDS88023.1

UniProtKB/TrEMBL

G3UX05

Related

ENSMUSP00000133498.2, ENSMUST00000173537.2
NM_133994.3 → NP_598755.1 glutathione S-transferase theta-3 isoform 1

See identical proteins and their annotated locations for NP_598755.1

Status: VALIDATED

Source sequence(s)

AC142499

Consensus CDS

CCDS23931.1

UniProtKB/Swiss-Prot

Q6P6I4, Q99L20

Related

ENSMUSP00000001715.4, ENSMUST00000001715.10

Conserved Domains (3) summary

cd03183
Location:92 → 216

GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases

COG0625
Location:3 → 217

GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]

cd03050
Location:3 → 78

GST_N_Theta; GST_N family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with ...