Sat2 spermidine/spermine N1-acetyl transferase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sat2provided by MGI
Official Full Name: spermidine/spermine N1-acetyl transferase 2provided by MGI
Primary source: MGI:MGI:1916465
See related: Ensembl:ENSMUSG00000069835 AllianceGenome:MGI:1916465
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SSAT2; SSAT-2; 2610016A03Rik
Summary: Predicted to enable diamine N-acetyltransferase activity and identical protein binding activity. Predicted to be involved in nor-spermidine metabolic process and polyamine acetylation. Predicted to act upstream of or within spermidine metabolic process and spermine metabolic process. Predicted to be located in cytoplasm. Orthologous to human SAT2 (spermidine/spermine N1-acetyltransferase family member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in cerebellum adult (RPKM 6.0), bladder adult (RPKM 5.2) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B3; 11 42.86 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (69512824..69514857)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (69621996..69624032)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SAT2 regulates Sertoli cell-germline interactions via STIM1-mediated ROS/WNT/beta-catenin signaling pathway.
Title: SAT2 regulates Sertoli cell-germline interactions via STIM1-mediated ROS/WNT/β-catenin signaling pathway.
Spermidine/spermine-N(1)-acetyltransferase ablation impacts tauopathy-induced polyamine stress response.
Title: Spermidine/spermine-N(1)-acetyltransferase ablation impacts tauopathy-induced polyamine stress response.
In testis tissue subjected to busulfan, increased expression of Sat2 can cause cellular injury and subsequent organ damage, which could lead to male infertility. Therefore, Sat2 may be a novel molecular target for treating busulfan-induced testicular toxicity.
Title: Increased Sat2 expression is associated with busulfan-induced testicular Sertoli cell injury.
These studies indicate that SAT2 deficient animals are protected against ischemia-reperfusion injuries (IRI) and suggest that SAT2 is an important mediator of the tissue damage in IRI.
Title: Spermidine/spermine-N1-acetyltransferase ablation protects against liver and kidney ischemia-reperfusion injury in mice.
Sat2 acts as a tumor promoter in the adenomaatous polyposis coli mouse (Min/+) model.
Title: Polyamine metabolism and tumorigenesis in the Apc(Min/+) mouse.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables N-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables N-acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables diamine N-acetyltransferase activity	ISA Inferred from Sequence Alignment more info	PubMed
enables diamine N-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
NOT enables diamine N-acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in nor-spermidine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in nor-spermidine metabolic process	ISO Inferred from Sequence Orthology more info
NOT involved_in polyamine biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in putrescine acetylation	IEA Inferred from Electronic Annotation more info
involved_in putrescine acetylation	ISO Inferred from Sequence Orthology more info
involved_in spermidine acetylation	ISO Inferred from Sequence Orthology more info
NOT involved_in spermidine acetylation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within spermidine metabolic process	ISA Inferred from Sequence Alignment more info	PubMed
involved_in spermine acetylation	IEA Inferred from Electronic Annotation more info
involved_in spermine acetylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spermine metabolic process	ISA Inferred from Sequence Alignment more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: thialysine N-epsilon-acetyltransferase

Names: diamine acetyltransferase 2; polyamine N-acetyltransferase 2; spermidine/spermine N(1)-acetyltransferase 2

NP_001343397.1

EC 2.3.1.57

NP_001343398.1

EC 2.3.1.57

NP_081267.1

EC 2.3.1.57

XP_006534173.1

EC 2.3.1.57

XP_006534174.1

EC 2.3.1.57

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356468.1 → NP_001343397.1 thialysine N-epsilon-acetyltransferase isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1).

Source sequence(s)

AI413743, AK011406, AV097768

Consensus CDS

CCDS36194.1

UniProtKB/Swiss-Prot

Q5F299, Q6P8J2

UniProtKB/TrEMBL

A0A158SIT0

Related

ENSMUSP00000090647.2, ENSMUST00000092969.2

Conserved Domains (1) summary

pfam00583
Location:71 → 144

Acetyltransf_1; Acetyltransferase (GNAT) family
NM_001356469.1 → NP_001343398.1 thialysine N-epsilon-acetyltransferase isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains a novel 3' terminal exon, resulting in novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AK161230, BE995938

UniProtKB/TrEMBL

Q3TTS0

Related

ENSMUST00000151255.2

Conserved Domains (1) summary

cl26092
Location:6 → 106

Acetyltransf_10; Acetyltransferase (GNAT) domain
NM_026991.3 → NP_081267.1 thialysine N-epsilon-acetyltransferase isoform 1

See identical proteins and their annotated locations for NP_081267.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1 and 2 encode the same isoform (1).

Source sequence(s)

AI413743, AK011406, AV097768, DV064807

Consensus CDS

CCDS36194.1

UniProtKB/Swiss-Prot

Q5F299, Q6P8J2

UniProtKB/TrEMBL

A0A158SIT0

Related

ENSMUSP00000104296.3, ENSMUST00000108656.9

Conserved Domains (1) summary

pfam00583
Location:71 → 144

Acetyltransf_1; Acetyltransferase (GNAT) family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

69512824..69514857

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006534111.4 → XP_006534174.1 thialysine N-epsilon-acetyltransferase isoform X1

See identical proteins and their annotated locations for XP_006534174.1

Conserved Domains (2) summary

COG0456
Location:6 → 167

RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]

pfam00583
Location:94 → 167

Acetyltransf_1; Acetyltransferase (GNAT) family
XM_006534110.3 → XP_006534173.1 thialysine N-epsilon-acetyltransferase isoform X1

See identical proteins and their annotated locations for XP_006534173.1

Conserved Domains (2) summary

COG0456
Location:6 → 167

RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]

pfam00583
Location:94 → 167

Acetyltransf_1; Acetyltransferase (GNAT) family