Ppp1r13b protein phosphatase 1, regulatory subunit 13B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ppp1r13bprovided by MGI
Official Full Name: protein phosphatase 1, regulatory subunit 13Bprovided by MGI
Primary source: MGI:MGI:1336199
See related: Ensembl:ENSMUSG00000021285 AllianceGenome:MGI:1336199
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p85; ASPP1; Tp53bp2; Trp53bp2
Summary: Predicted to enable p53 binding activity. Predicted to be involved in intrinsic apoptotic signaling pathway by p53 class mediator. Predicted to be located in several cellular components, including cytosol; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including blood; brain; cardiovascular system; embryo mesenchyme; and yolk sac. Orthologous to human PPP1R13B (protein phosphatase 1 regulatory subunit 13B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in lung adult (RPKM 13.8), genital fat pad adult (RPKM 10.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 F1; 12 61.14 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (111794892..111874549, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (111828457..111908119, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interdependent Nuclear Co-Trafficking of ASPP1 and p53 Aggravates Cardiac Ischemia/Reperfusion Injury.
Title: Interdependent Nuclear Co-Trafficking of ASPP1 and p53 Aggravates Cardiac Ischemia/Reperfusion Injury.
After genotoxic stress, Aspp1 promotes hematopoietic stem cell (HSC) cycling and induces p53-dependent apoptosis in cells with persistent DNA damage foci. Aspp1 also attenuates HSC self-renewal and accumulation of DNA damage in p53 null HSCs.
Title: Aspp1 Preserves Hematopoietic Stem Cell Pool Integrity and Prevents Malignant Transformation.
Our study demonstrates a novel role for ASPP1 and ASPP2 in the death of retinal ganglion cells.
Title: ASPP1/2 regulate p53-dependent death of retinal ganglion cells through PUMA and Fas/CD95 activation in vivo.
Aspp1 plays a crucial role in the initial assembly and function of lymphatic vessels during mouse development in a p53-independent manner.
Title: Lymphatic vessel assembly is impaired in Aspp1-deficient mouse embryos.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C85416 (e-PCR)
- UniSTS:160256

AW545810 (e-PCR)
- UniSTS:180485

AW558780 (e-PCR)
- UniSTS:180486

AI449786 (e-PCR)
- UniSTS:164515

AU014939 (e-PCR)
- UniSTS:207280

RH125146 (e-PCR)
- UniSTS:161968

Ppp1r13b (e-PCR), detects polymorphism
- UniSTS:548046

RH127188 (e-PCR)
- UniSTS:208876

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables p53 binding	IBA Inferred from Biological aspect of Ancestor more info
enables p53 binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intrinsic apoptotic signaling pathway by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway by p53 class mediator	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell cycle	IEA Inferred from Electronic Annotation more info
involved_in regulation of apoptotic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: apoptosis-stimulating of p53 protein 1

Names: protein phosphatase 1, regulatory (inhibitor) subunit 13B; transformation related protein 53 binding protein 2; tumor protein p53 binding protein, 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011625.1 → NP_035755.1 apoptosis-stimulating of p53 protein 1

See identical proteins and their annotated locations for NP_035755.1

Status: PROVISIONAL

Source sequence(s)

BC054788

Consensus CDS

CCDS56866.1

UniProtKB/Swiss-Prot

Q62415

UniProtKB/TrEMBL

A0A1Y7VJH3

Related

ENSMUSP00000062464.8, ENSMUST00000054815.15

Conserved Domains (7) summary

cd00204
Location:883 → 1006

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam07321
Location:154 → 317

YscO; Type III secretion protein YscO

pfam12796
Location:889 → 975

Ank_2; Ankyrin repeats (3 copies)

pfam13863
Location:153 → 247

DUF4200; Domain of unknown function (DUF4200)

sd00045
Location:889 → 915

ANK; ANK repeat [structural motif]

cl09111
Location:208 → 318

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

cl17036
Location:1019 → 1075

SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

111794892..111874549 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006515796.5 → XP_006515859.1 apoptosis-stimulating of p53 protein 1 isoform X1

UniProtKB/TrEMBL

A0A1Y7VJH3

Conserved Domains (6) summary

PHA03247
Location:479 → 895

PHA03247; large tegument protein UL36; Provisional

TIGR02168
Location:153 → 329

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

sd00045
Location:924 → 950

ANK; ANK repeat [structural motif]

cd17224
Location:2 → 86

RA_ASPP1; Ras-associating (RA) domain found in apoptosis-stimulating protein of p53 protein 1 (ASPP1)

pfam12796
Location:924 → 1010

Ank_2; Ankyrin repeats (3 copies)

cl17036
Location:1054 → 1110

SH3; Src Homology 3 domain superfamily
XM_006515797.5 → XP_006515860.1 apoptosis-stimulating of p53 protein 1 isoform X2

UniProtKB/TrEMBL

A0A1Y7VJH3

Related

ENSMUSP00000152424.2, ENSMUST00000220486.2

Conserved Domains (6) summary

PHA03247
Location:476 → 892

PHA03247; large tegument protein UL36; Provisional

TIGR02168
Location:150 → 326

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

sd00045
Location:921 → 947

ANK; ANK repeat [structural motif]

cd17224
Location:1 → 83

RA_ASPP1; Ras-associating (RA) domain found in apoptosis-stimulating protein of p53 protein 1 (ASPP1)

pfam12796
Location:921 → 1007

Ank_2; Ankyrin repeats (3 copies)

cl17036
Location:1051 → 1107

SH3; Src Homology 3 domain superfamily
XM_030246683.2 → XP_030102543.1 apoptosis-stimulating of p53 protein 1 isoform X3

UniProtKB/TrEMBL

A0A1Y7VJH3

Conserved Domains (6) summary

PHA03247
Location:441 → 857

PHA03247; large tegument protein UL36; Provisional

TIGR02168
Location:150 → 326

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

sd00045
Location:886 → 912

ANK; ANK repeat [structural motif]

cd17224
Location:1 → 83

RA_ASPP1; Ras-associating (RA) domain found in apoptosis-stimulating protein of p53 protein 1 (ASPP1)

pfam12796
Location:886 → 972

Ank_2; Ankyrin repeats (3 copies)

cl17036
Location:1016 → 1072

SH3; Src Homology 3 domain superfamily