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    Sh2d4b SH2 domain containing 4B [ Mus musculus (house mouse) ]

    Gene ID: 328381, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Sh2d4bprovided by MGI
    Official Full Name
    SH2 domain containing 4Bprovided by MGI
    Primary source
    MGI:MGI:1925182
    See related
    Ensembl:ENSMUSG00000037833 AllianceGenome:MGI:1925182
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D030001E08; A430109M18Rik
    Summary
    Predicted to be active in cytoplasm. Is expressed in cerebral cortex; heart ventricle; thalamus mantle layer; and thymus primordium. Orthologous to human SH2D4B (SH2 domain containing 4B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Sh2d4b in Genome Data Viewer
    Location:
    14 B; 14 22.36 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (40533478..40624294, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (40811521..40902337, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_36458 Neighboring gene STARR-seq mESC enhancer starr_36459 Neighboring gene protein tyrosine phosphatase 4a1 pseudogene Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_36460 Neighboring gene STARR-seq mESC enhancer starr_36461 Neighboring gene STARR-seq mESC enhancer starr_36462 Neighboring gene STARR-seq mESC enhancer starr_36464 Neighboring gene STARR-seq mESC enhancer starr_36467 Neighboring gene STARR-seq mESC enhancer starr_36469 Neighboring gene tetraspanin 14 Neighboring gene STARR-positive B cell enhancer ABC_E9893 Neighboring gene VISTA enhancer mm1503 Neighboring gene STARR-positive B cell enhancer ABC_E4105 Neighboring gene STARR-positive B cell enhancer ABC_E8554 Neighboring gene predicted gene, 31839

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    2. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SH2 domain-containing protein 4B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368700.2 → NP_001355629.1  SH2 domain-containing protein 4B isoform b

      Status: VALIDATED

      Source sequence(s)
      CT025537
      Related
      ENSMUST00000225854.2
      Conserved Domains (1) summary
      pfam17380
      Location:30 → 201
      DUF5401; Family of unknown function (DUF5401)

    2. NM_001368701.2 → NP_001355630.1  SH2 domain-containing protein 4B isoform b

      Status: VALIDATED

      Source sequence(s)
      CT025537
      Conserved Domains (1) summary
      pfam17380
      Location:30 → 201
      DUF5401; Family of unknown function (DUF5401)

    3. NM_177816.5 → NP_808484.2  SH2 domain-containing protein 4B isoform a

      See identical proteins and their annotated locations for NP_808484.2

      Status: VALIDATED

      Source sequence(s)
      CT025537
      Consensus CDS
      CCDS26955.1
      UniProtKB/Swiss-Prot
      A6X942, B2RSQ7, Q8BQI0
      Related
      ENSMUSP00000093699.4, ENSMUST00000096000.4
      Conserved Domains (2) summary
      cd10351
      Location:317 → 419
      SH2_SH2D4B; Src homology 2 domain found in the SH2 domain containing protein 4B (SH2D4B)
      pfam17380
      Location:92 → 271
      DUF5401; Family of unknown function (DUF5401)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      40533478..40624294 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519136.2 → XP_006519199.1  SH2 domain-containing protein 4B isoform X1

      Conserved Domains (2) summary
      cd10351
      Location:326 → 428
      SH2_SH2D4B; Src homology 2 domain found in the SH2 domain containing protein 4B (SH2D4B)
      pfam17380
      Location:101 → 280
      DUF5401; Family of unknown function (DUF5401)

    2. XM_006519137.4 → XP_006519200.1  SH2 domain-containing protein 4B isoform X2

      See identical proteins and their annotated locations for XP_006519200.1

      Conserved Domains (2) summary
      PTZ00121
      Location:19 → 272
      PTZ00121; MAEBL; Provisional
      cd10351
      Location:236 → 338
      SH2_SH2D4B; Src homology 2 domain found in the SH2 domain containing protein 4B (SH2D4B)

    3. XM_017316059.3 → XP_017171548.1  SH2 domain-containing protein 4B isoform X2

      Conserved Domains (2) summary
      PTZ00121
      Location:19 → 272
      PTZ00121; MAEBL; Provisional
      cd10351
      Location:236 → 338
      SH2_SH2D4B; Src homology 2 domain found in the SH2 domain containing protein 4B (SH2D4B)

    4. XM_006519139.3 → XP_006519202.1  SH2 domain-containing protein 4B isoform X2

      See identical proteins and their annotated locations for XP_006519202.1

      Conserved Domains (2) summary
      PTZ00121
      Location:19 → 272
      PTZ00121; MAEBL; Provisional
      cd10351
      Location:236 → 338
      SH2_SH2D4B; Src homology 2 domain found in the SH2 domain containing protein 4B (SH2D4B)

    RNA

    1. XR_383190.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6X942.1 GenPept UniProtKB/Swiss-Prot:A6X942

    Gene LinkOut

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