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    Cd80 CD80 antigen [ Mus musculus (house mouse) ]

    Gene ID: 12519, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cd80provided by MGI
    Official Full Name
    CD80 antigenprovided by MGI
    Primary source
    MGI:MGI:101775
    See related
    Ensembl:ENSMUSG00000075122 AllianceGenome:MGI:101775
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B71; Ly53; TSA1; Cd28l; Ly-53; MIC17
    Summary
    Predicted to enable receptor ligand activity. Acts upstream of or within T cell costimulation; cellular response to lipopolysaccharide; and positive regulation of alpha-beta T cell proliferation. Located in external side of plasma membrane. Is expressed in heart ventricle and skin. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human CD80 (CD80 molecule). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Cd80 in Genome Data Viewer
    Location:
    16 B4; 16 26.86 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (38277793..38316682)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (38457430..38495958)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40819 Neighboring gene STARR-seq mESC enhancer starr_40820 Neighboring gene predicted gene, 36333 Neighboring gene STARR-seq mESC enhancer starr_40821 Neighboring gene STARR-positive B cell enhancer ABC_E9931 Neighboring gene ADP-ribosylarginine hydrolase Neighboring gene STARR-seq mESC enhancer starr_40823 Neighboring gene STARR-positive B cell enhancer ABC_E9164 Neighboring gene STARR-seq mESC enhancer starr_40825 Neighboring gene STARR-positive B cell enhancer ABC_E7448 Neighboring gene SET domain-containing protein 8 pseudogene Neighboring gene predicted gene, 41453 Neighboring gene creatine kinase pseudogene 3 Neighboring gene translocase of inner mitochondrial membrane domain containing 1 Neighboring gene ubiquitin-like, containing PHD and RING finger domains, 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_40830 Neighboring gene predicted gene, 53953 Neighboring gene protein O-glucosyltransferase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CD80 in immune suppression by mouse ovarian carcinoma-associated Gr-1+CD11b+ myeloid cells. Yang R, et al. Cancer Res, 2006 Jul 1. PMID 16818658
    2. Simultaneous expression of allogenic class II MHC and B7.1 (CD80) molecules in A20 B-lymphoma cell line enhances tumor immunogenicity. Jang YJ, et al. Mol Cells, 2002 Feb 28. PMID 11911464
    3. In vivo immunogenicity of osteosarcoma cells that express B7-1a, an alternatively spliced form of B7-1. Nagamori M, et al. Anticancer Res, 2002 Jul-Aug. PMID 12174878
    4. Mouse vascular endothelium activates CD8+ T lymphocytes in a B7-dependent fashion. Kreisel D, et al. J Immunol, 2002 Dec 1. PMID 12444119
    5. Melphalan-induced up-regulation of B7-1 surface expression on normal splenic B cells. Donepudi M, et al. Cancer Immunol Immunother, 2003 Mar. PMID 12649745, Free PMC Article

    See all (379) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Presence of CD80 and Absence of LAT in Modulating Cellular Infiltration and HSV-1 Latency.
      Title: Presence of CD80 and Absence of LAT in Modulating Cellular Infiltration and HSV-1 Latency.
    2. CD80 on skin stem cells promotes local expansion of regulatory T cells upon injury to orchestrate repair within an inflammatory environment.
      Title: CD80 on skin stem cells promotes local expansion of regulatory T cells upon injury to orchestrate repair within an inflammatory environment.
    3. Absence of CD80 reduces HSV-1 replication in the eye and delays reactivation but not latency levels.
      Title: Absence of CD80 reduces HSV-1 replication in the eye and delays reactivation but not latency levels.
    4. cis-B7:CD28 interactions at invaginated synaptic membranes provide CD28 co-stimulation and promote CD8[+] T cell function and anti-tumor immunity.
      Title: cis-B7:CD28 interactions at invaginated synaptic membranes provide CD28 co-stimulation and promote CD8(+) T cell function and anti-tumor immunity.
    5. CTLA-4-Ig internalizes CD80 in fibroblast-like synoviocytes from chronic inflammatory arthritis mouse model.
      Title: CTLA-4-Ig internalizes CD80 in fibroblast-like synoviocytes from chronic inflammatory arthritis mouse model.
    6. Lack of Functional P110delta Affects Expression of Activation Marker CD80 but Does Not Influence Functions of Neutrophils.
      Title: Lack of Functional P110δ Affects Expression of Activation Marker CD80 but Does Not Influence Functions of Neutrophils.
    7. Suppression of CD80 Expression by ICP22 Affects Herpes Simplex Virus Type 1 Replication and CD8(+)IFN-gamma(+) Infiltrates in the Eyes of Infected Mice but Not Latency Reactivation.
      Title: Suppression of CD80 Expression by ICP22 Affects Herpes Simplex Virus Type 1 Replication and CD8(+)IFN-γ(+) Infiltrates in the Eyes of Infected Mice but Not Latency Reactivation.
    8. B7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanisms.
      Title: B7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanisms.
    9. Expression of Murine CD80 by Herpes Simplex Virus 1 in Place of Latency-Associated Transcript (LAT) Can Compensate for Latency Reactivation and Anti-apoptotic Functions of LAT.
      Title: Expression of Murine CD80 by Herpes Simplex Virus 1 in Place of Latency-Associated Transcript (LAT) Can Compensate for Latency Reactivation and Anti-apoptotic Functions of LAT.
    10. these results suggest that increased CD80 levels promote increased CD8(+) T cells, leading to exacerbated eye disease in HSV-1-infected mice.
      Title: CD80 Plays a Critical Role in Increased Inflammatory Responses in Herpes Simplex Virus 1-Infected Mouse Corneas.
    Submit: New GeneRIF Correction See all GeneRIFs (145)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables coreceptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables receptor ligand activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in T cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in T cell costimulation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within T cell costimulation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to lipopolysaccharide IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cellular response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of T cell mediated immunity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of T cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of T cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of T cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of alpha-beta T cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein complex involved in cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    T-lymphocyte activation antigen CD80
    Names
    B7 protein
    activation B7-1 antigen

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359898.1 → NP_001346827.1  T-lymphocyte activation antigen CD80 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC209577
      Consensus CDS
      CCDS28168.1
      UniProtKB/Swiss-Prot
      Q00609, Q61332
      UniProtKB/TrEMBL
      Q3U4B5, Q549R2, Q9R1Z9
      Conserved Domains (2) summary
      cd16083
      Location:145 → 235
      IgC_CD80; Immunoglobulin constant (IgC)-like domain of antigen receptor CD80
      cd16086
      Location:39 → 142
      IgV_CD80; Immunoglobulin variable domain (IgV) in CD80

    2. NM_009855.2 → NP_033985.3  T-lymphocyte activation antigen CD80 precursor

      See identical proteins and their annotated locations for NP_033985.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC154425, X60958
      Consensus CDS
      CCDS28168.1
      UniProtKB/Swiss-Prot
      Q00609, Q61332
      UniProtKB/TrEMBL
      Q3U4B5, Q549R2, Q9R1Z9
      Related
      ENSMUSP00000097404.3, ENSMUST00000099816.3
      Conserved Domains (2) summary
      cd16083
      Location:145 → 235
      IgC_CD80; Immunoglobulin constant (IgC)-like domain of antigen receptor CD80
      cd16086
      Location:39 → 142
      IgV_CD80; Immunoglobulin variable domain (IgV) in CD80

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      38277793..38316682
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159758.1 → XP_036015651.1  T-lymphocyte activation antigen CD80 isoform X1

      UniProtKB/TrEMBL
      Q3U4B5
      Related
      ENSMUSP00000156031.2, ENSMUST00000231716.2
      Conserved Domains (2) summary
      cd16086
      Location:47 → 150
      IgV_CD80; Immunoglobulin variable domain (IgV) in Cluster of Differentiation (CD) 80
      cd16083
      Location:153 → 243
      IgC1_CD80; Immunoglobulin constant (IgC)-like domain of antigen receptor Cluster of Differentiation (CD) 80; member of the C1-set of Ig superfamily (IgSF) domains

    2. XM_030248945.2 → XP_030104805.1  T-lymphocyte activation antigen CD80 isoform X2

      Related
      ENSMUSP00000156252.2, ENSMUST00000232409.2
      Conserved Domains (1) summary
      cl11960
      Location:47 → 150
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q00609.1 GenPept UniProtKB/Swiss-Prot:Q00609

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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