Siglec15 sialic acid binding Ig-like lectin 15 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Siglec15provided by MGI
Official Full Name: sialic acid binding Ig-like lectin 15provided by MGI
Primary source: MGI:MGI:3646642
See related: Ensembl:ENSMUSG00000091055 AllianceGenome:MGI:3646642
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cd33l3; EG620235; SIGLEC-I
Summary: Acts upstream of or within regulation of actin cytoskeleton organization; regulation of bone resorption; and regulation of osteoclast development. Located in plasma membrane. Part of protein-containing complex. Is expressed in eye; immune system; reproductive system; and stomach. Orthologous to human SIGLEC15 (sialic acid binding Ig like lectin 15). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in ovary adult (RPKM 17.6) and thymus adult (RPKM 2.6) See more
Orthologs: human all
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Genomic context

Location:: 18 E3; 18 52.43 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (78085708..78100656, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (78042493..78057441, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Involvement of Siglec-15 in regulating RAP1/RAC signaling in cytoskeletal remodeling in osteoclasts mediated by macrophage colony-stimulating factor.
Title: Involvement of Siglec-15 in regulating RAP1/RAC signaling in cytoskeletal remodeling in osteoclasts mediated by macrophage colony-stimulating factor.
Osteoclast-derived apoptotic bodies inhibit naive CD8[+] T cell activation via Siglec15, promoting breast cancer secondary metastasis.
Title: Osteoclast-derived apoptotic bodies inhibit naive CD8(+) T cell activation via Siglec15, promoting breast cancer secondary metastasis.
Siglec-15 Promotes Evasion of Adaptive Immunity in B-cell Acute Lymphoblastic Leukemia.
Title: Siglec-15 Promotes Evasion of Adaptive Immunity in B-cell Acute Lymphoblastic Leukemia.
Dynamic change in Siglec-15 expression in peritumoral macrophages confers an immunosuppressive microenvironment and poor outcome in glioma.
Title: Dynamic change in Siglec-15 expression in peritumoral macrophages confers an immunosuppressive microenvironment and poor outcome in glioma.
[Study on the effect and mechanisms of SIGLEC-15 on laryngeal squamous cell carcinoma].
Title: [Study on the effect and mechanisms of SIGLEC-15 on laryngeal squamous cell carcinoma].
Molecular structure, expression, and the emerging role of Siglec-15 in skeletal biology and cancer.
Title: Molecular structure, expression, and the emerging role of Siglec-15 in skeletal biology and cancer.
Siglec-15 on Osteoclasts Is Crucial for Bone Erosion in Serum-Transfer Arthritis.
Title: Siglec-15 on Osteoclasts Is Crucial for Bone Erosion in Serum-Transfer Arthritis.
Siglec-15 is a potential target for normalization cancer immunotherapy.
Title: Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy.
Siglec-15 does not mediate joint destruction in inflammatory arthritis
Title: Sialic acid-binding immunoglobulin-like lectin 15 (Siglec-15) mediates periarticular bone loss, but not joint destruction, in murine antigen-induced arthritis.
The present findings indicate that Siglec-15 is involved in estrogen deficiency-induced differentiation of osteoclasts and is thus a potential therapeutic target for postmenopausal osteoporosis.
Title: Siglec-15 is a potential therapeutic target for postmenopausal osteoporosis.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (9)
Targeted (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of bone resorption	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of bone resorption	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of osteoclast development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of osteoclast development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of osteoclast development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: sialic acid-binding Ig-like lectin 15

Names: CD33 molecule-like 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001101038.2 → NP_001094508.1 sialic acid-binding Ig-like lectin 15 precursor

See identical proteins and their annotated locations for NP_001094508.1

Status: VALIDATED

Source sequence(s)

AC126553

Consensus CDS

CCDS50329.1

UniProtKB/TrEMBL

A7E1W8

Related

ENSMUSP00000126901.3, ENSMUST00000170760.3

Conserved Domains (4) summary

cd00096
Location:188 → 250

Ig; Immunoglobulin domain

smart00410
Location:49 → 164

IG_like; Immunoglobulin like

pfam07679
Location:169 → 251

I-set; Immunoglobulin I-set domain

cl11960
Location:44 → 149

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

78085708..78100656 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030250561.1 → XP_030106421.1 sialic acid-binding Ig-like lectin 15 isoform X1

Conserved Domains (2) summary

cd00096
Location:187 → 249

Ig; Immunoglobulin domain

cl11960
Location:44 → 149

Ig; Immunoglobulin domain
XM_036161229.1 → XP_036017122.1 sialic acid-binding Ig-like lectin 15 isoform X3

Conserved Domains (2) summary

cd00096
Location:6 → 10

Ig; Ig strand A' [structural motif]

cl11960
Location:2 → 100

Ig; Immunoglobulin domain
XM_011247091.3 → XP_011245393.1 sialic acid-binding Ig-like lectin 15 isoform X2

Conserved Domains (2) summary

cd00096
Location:188 → 250

Ig; Immunoglobulin domain

cl11960
Location:44 → 149

Ig; Immunoglobulin domain