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    Ryr3 ryanodine receptor 3 [ Mus musculus (house mouse) ]

    Gene ID: 20192, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ryr3provided by MGI
    Official Full Name
    ryanodine receptor 3provided by MGI
    Primary source
    MGI:MGI:99684
    See related
    Ensembl:ENSMUSG00000057378 AllianceGenome:MGI:99684
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RYR-3; C230090H21
    Summary
    Enables ryanodine-sensitive calcium-release channel activity. Acts upstream of or within intracellular calcium ion homeostasis and striated muscle contraction. Located in sarcoplasmic reticulum membrane. Part of junctional membrane complex. Is expressed in several structures, including cardiovascular system; central nervous system; diaphragm; hemolymphoid system; and musculature. Human ortholog(s) of this gene implicated in congenital myopathy 20 and hepatocellular carcinoma. Orthologous to human RYR3 (ryanodine receptor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E18 (RPKM 3.5), bladder adult (RPKM 2.8) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ryr3 in Genome Data Viewer
    Location:
    2 E3- E4; 2 57.2 cM
    Exon count:
    106
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (112461699..113047755, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (112631354..113217405, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11150 Neighboring gene STARR-positive B cell enhancer ABC_E4487 Neighboring gene STARR-seq mESC enhancer starr_05388 Neighboring gene predicted gene, 22676 Neighboring gene ER membrane protein complex subunit 7 Neighboring gene cholinergic receptor, muscarinic 5 Neighboring gene STARR-positive B cell enhancer mm9_chr2:112443695-112443995 Neighboring gene apoptosis, caspase activation inhibitor Neighboring gene STARR-seq mESC enhancer starr_05389 Neighboring gene STARR-seq mESC enhancer starr_05390 Neighboring gene STARR-seq mESC enhancer starr_05392 Neighboring gene STARR-seq mESC enhancer starr_05393 Neighboring gene STARR-seq mESC enhancer starr_05394 Neighboring gene STARR-seq mESC enhancer starr_05395 Neighboring gene STARR-seq mESC enhancer starr_05396 Neighboring gene predicted gene, 26505 Neighboring gene transmembrane and coiled-coil domains 5B Neighboring gene STARR-seq mESC enhancer starr_05397 Neighboring gene STARR-seq mESC enhancer starr_05399 Neighboring gene formin 1 Neighboring gene STARR-seq mESC enhancer starr_05401 Neighboring gene predicted gene, 54142

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Regulation of calcium sparks and spontaneous transient outward currents by RyR3 in arterial vascular smooth muscle cells. Löhn M, et al. Circ Res, 2001 Nov 23. PMID 11717163
    2. The role of ryanodine receptor type 3 in a mouse model of Alzheimer disease. Liu J, et al. Channels (Austin), 2014. PMID 24476841, Free PMC Article
    3. Spatially segregated control of Ca2+ release in developing skeletal muscle of mice. Shirokova N, et al. J Physiol, 1999 Dec 1. PMID 10581317, Free PMC Article
    4. Facilitation of NMDAR-independent LTP and spatial learning in mutant mice lacking ryanodine receptor type 3. Futatsugi A, et al. Neuron, 1999 Nov. PMID 10595520
    5. Involvement of ryanodine receptor type 3 in dopamine release from the striatum: evidence from mutant mice lacking this receptor. Wan K, et al. Biochem Biophys Res Commun, 1999 Dec 20. PMID 10600547

    See all (102) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Spatial Learning Is Associated with Antagonist Outcomes for DNA Methylation and DNA Hydroxymethylation in the Transcriptional Regulation of the Ryanodine Receptor 3.
      Title: Spatial Learning Is Associated with Antagonist Outcomes for DNA Methylation and DNA Hydroxymethylation in the Transcriptional Regulation of the Ryanodine Receptor 3.
    2. Extraocular muscle function is impaired in ryr3 (-/-) mice.
      Title: Extraocular muscle function is impaired in ryr3 (-/-) mice.
    3. calsenilin controls the activity of neuronal RyRs.
      Title: Control of Neuronal Ryanodine Receptor-Mediated Calcium Signaling by Calsenilin.
    4. Deletion of RyanR3 increased hippocampal neuronal network excitability and accelerated Alzheimer disease pathology.
      Title: The role of ryanodine receptor type 3 in a mouse model of Alzheimer disease.
    5. Data indicate that TPPII can regulate sperm maturation by modulating intracellular Ca(2+) stores via the type 3 RyR.
      Title: Tripeptidyl peptidase II regulates sperm function by modulating intracellular Ca(2+) stores via the ryanodine receptor.
    6. knockdown of RyR1-3 expression in wild-type hippocampal neurons to levels comparable with the RyR protein reduction in presenilin-deficient hippocampal neurons mimics the defects exhibited in calcium homeostasis and presynaptic function
      Title: Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons.
    7. Silencing of RyR3 expression in 3T3-L1 preadipocytes resulted in up-regulated adiponectin promoter activity, enhanced adiponectin mRNA expression, and more adiponectin protein secreted into the medium.
      Title: Knockdown of RyR3 enhances adiponectin expression through an atf3-dependent pathway.
    8. A selective involvement of RyR1 and RyR3 in supraspinal muscarinic analgesia was demonstrated
      Title: Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study.
    9. Report heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells.
      Title: Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells.
    10. Although RyR3 immunostaining appeared in the dendrites of granule cells, more intense RyR3 staining in rolling mice than in controls was uniformly observed throughout all cerebellar lobules
      Title: Differential alterations in expressions of ryanodine receptor subtypes in cerebellar cortical neurons of an ataxic mutant, rolling mouse Nagoya.
    Submit: New GeneRIF Correction See all GeneRIFs (22)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-induced calcium release activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables intracellularly gated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ryanodine-sensitive calcium-release channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ryanodine-sensitive calcium-release channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ryanodine-sensitive calcium-release channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ryanodine-sensitive calcium-release channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ryanodine-sensitive calcium-release channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to ATP ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to caffeine ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to calcium ion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to magnesium ion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within intracellular calcium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein homotetramerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in striated muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within striated muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Z disc IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of calcium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of junctional membrane complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in sarcolemma IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in sarcoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sarcoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in smooth endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ryanodine receptor 3
    Names
    brain ryanodine receptor-calcium release channel
    brain-type ryanodine receptor
    calcium release channel
    type 3 ryanodine receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001319156.1 → NP_001306085.1  ryanodine receptor 3

      Status: VALIDATED

      Source sequence(s)
      AI851294, AK082701, AL672250, AL691423, AL732316, CJ060048
      Consensus CDS
      CCDS50661.2
      UniProtKB/TrEMBL
      A0A140LJF7, A0A140LJK7
      Related
      ENSMUSP00000147250.2, ENSMUST00000208290.2
      Conserved Domains (12) summary
      smart00472
      Location:275 → 368
      MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
      cd12877
      Location:641 → 792
      SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
      cd12878
      Location:1072 → 1204
      SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
      pfam00520
      Location:4619 → 4779
      Ion_trans; Ion transport protein
      pfam01365
      Location:442 → 621
      RYDR_ITPR; RIH domain
      pfam02026
      Location:849 → 937
      RyR; RyR domain
      pfam02815
      Location:216 → 397
      MIR; MIR domain
      pfam06459
      Location:4232 → 4502
      RR_TM4-6; Ryanodine Receptor TM 4-6
      pfam08454
      Location:3729 → 3842
      RIH_assoc; RyR and IP3R Homology associated
      pfam13833
      Location:3933 → 3981
      EF-hand_8; EF-hand domain pair
      cd12879
      Location:1324 → 1462
      SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
      cl19745
      Location:10 → 207
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      112461699..113047755 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316702.3 → XP_017172191.1  ryanodine receptor 3 isoform X2

      UniProtKB/TrEMBL
      A0A140LJF7
      Conserved Domains (11) summary
      cd12877
      Location:667 → 818
      SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
      cd12878
      Location:1099 → 1231
      SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
      cd12879
      Location:1351 → 1489
      SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
      pfam00520
      Location:4641 → 4801
      Ion_trans; Ion transport protein
      pfam01365
      Location:451 → 632
      RYDR_ITPR; RIH domain
      pfam02026
      Location:875 → 963
      RyR; RyR domain
      pfam02815
      Location:227 → 408
      MIR; MIR domain
      pfam06459
      Location:4254 → 4524
      RR_TM4-6; Ryanodine Receptor TM 4-6
      pfam08454
      Location:3751 → 3864
      RIH_assoc; RyR and IP3R Homology associated
      pfam13833
      Location:3955 → 4003
      EF-hand_8; EF-hand domain pair
      cl19745
      Location:14 → 218
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

    2. XM_017316700.3 → XP_017172189.1  ryanodine receptor 3 isoform X1

      UniProtKB/TrEMBL
      A0A140LJF7
      Conserved Domains (11) summary
      cd12877
      Location:667 → 818
      SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
      cd12878
      Location:1099 → 1231
      SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
      cd12879
      Location:1351 → 1489
      SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
      pfam00520
      Location:4646 → 4806
      Ion_trans; Ion transport protein
      pfam01365
      Location:451 → 632
      RYDR_ITPR; RIH domain
      pfam02026
      Location:875 → 963
      RyR; RyR domain
      pfam02815
      Location:227 → 408
      MIR; MIR domain
      pfam06459
      Location:4259 → 4529
      RR_TM4-6; Ryanodine Receptor TM 4-6
      pfam08454
      Location:3756 → 3869
      RIH_assoc; RyR and IP3R Homology associated
      pfam13833
      Location:3960 → 4008
      EF-hand_8; EF-hand domain pair
      cl19745
      Location:14 → 218
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

    3. XM_017316705.3 → XP_017172194.1  ryanodine receptor 3 isoform X3

      UniProtKB/Swiss-Prot
      A2AGL3, P70184, P70185, Q3V1H0, Q4JFC4, Q60836, Q62175, Q62198, Q9QY91
      UniProtKB/TrEMBL
      A0A140LJF7
      Related
      ENSMUSP00000079503.6, ENSMUST00000080673.13
      Conserved Domains (11) summary
      cd12877
      Location:641 → 792
      SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
      cd12878
      Location:1072 → 1204
      SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
      cd12879
      Location:1324 → 1462
      SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
      pfam00520
      Location:4614 → 4774
      Ion_trans; Ion transport protein
      pfam01365
      Location:440 → 621
      RYDR_ITPR; RIH domain
      pfam02026
      Location:849 → 937
      RyR; RyR domain
      pfam02815
      Location:216 → 397
      MIR; MIR domain
      pfam06459
      Location:4227 → 4497
      RR_TM4-6; Ryanodine Receptor TM 4-6
      pfam08454
      Location:3724 → 3837
      RIH_assoc; RyR and IP3R Homology associated
      pfam13833
      Location:3928 → 3976
      EF-hand_8; EF-hand domain pair
      cl19745
      Location:14 → 207
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

    4. XM_017316709.3 → XP_017172198.1  ryanodine receptor 3 isoform X4

      Conserved Domains (7) summary
      cd12877
      Location:667 → 818
      SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
      cd12878
      Location:1099 → 1231
      SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
      cd12879
      Location:1351 → 1489
      SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
      pfam01365
      Location:451 → 632
      RYDR_ITPR; RIH domain
      pfam02026
      Location:875 → 963
      RyR; RyR domain
      pfam02815
      Location:227 → 408
      MIR; MIR domain
      cl19745
      Location:14 → 218
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

    RNA

    1. XR_004939164.1 RNA Sequence

    2. XR_004939166.1 RNA Sequence

    3. XR_003951556.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_177652.2: Suppressed sequence

      Description
      NM_177652.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2AGL3.1 GenPept UniProtKB/Swiss-Prot:A2AGL3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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