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    Vopp1 vesicular, overexpressed in cancer, prosurvival protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 232023, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vopp1provided by MGI
    Official Full Name
    vesicular, overexpressed in cancer, prosurvival protein 1provided by MGI
    Primary source
    MGI:MGI:2141658
    See related
    Ensembl:ENSMUSG00000037788 AllianceGenome:MGI:2141658
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ecop
    Summary
    Predicted to enable enzyme binding activity. Predicted to be located in cytoplasmic vesicle membrane; late endosome; and lysosome. Predicted to be active in organelle membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and neural retina. Orthologous to human VOPP1 (VOPP1 WW domain binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E18 (RPKM 31.4), CNS E14 (RPKM 28.2) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Vopp1 in Genome Data Viewer
    Location:
    6 B3; 6 27.82 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (57729249..57802110, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (57752264..57827983, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene Pigy upstream reading frame Neighboring gene LanC (bacterial lantibiotic synthetase component C)-like 2 Neighboring gene STARR-positive B cell enhancer ABC_E9272 Neighboring gene vomeronasal 1 receptor 21 Neighboring gene predicted gene, 25726

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of new ciliary signaling pathways in the brain and insights into neurological disorders. Loukil A, et al. bioRxiv, 2023 Dec 21. PMID 38187761, Free PMC Article
    2. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
    3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    4. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in organelle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in organelle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in organelle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    WW domain binding protein VOPP1
    Names
    EGFR-coamplified and overexpressed protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411586.1 → NP_001398515.1  WW domain binding protein VOPP1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC127307

    2. NM_001411587.1 → NP_001398516.1  WW domain binding protein VOPP1 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC127307, AC144816

    3. NM_001411588.1 → NP_001398517.1  WW domain binding protein VOPP1 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC127307, AC144816

    4. NM_001411589.1 → NP_001398518.1  WW domain binding protein VOPP1 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC127307, AC144816

    5. NM_001411590.1 → NP_001398519.1  WW domain binding protein VOPP1 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC127307, AC144816

    6. NM_146168.1 → NP_666280.1  WW domain binding protein VOPP1 isoform a precursor

      See identical proteins and their annotated locations for NP_666280.1

      Status: VALIDATED

      Source sequence(s)
      BC024822
      Consensus CDS
      CCDS39497.1
      UniProtKB/Swiss-Prot
      Q3TZ79, Q8C0B7, Q8R1C3
      Related
      ENSMUSP00000109936.3, ENSMUST00000114297.5

    RNA

    1. NR_177289.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC127307, AC144816

    2. NR_177290.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC127307, AC144816

    3. NR_177291.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC127307, AC144816

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      57729249..57802110 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R1C3.1 GenPept UniProtKB/Swiss-Prot:Q8R1C3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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