Nlrp10 NLR family, pyrin domain containing 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nlrp10provided by MGI
Official Full Name: NLR family, pyrin domain containing 10provided by MGI
Primary source: MGI:MGI:2444084
See related: Ensembl:ENSMUSG00000049709 AllianceGenome:MGI:2444084
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PAN5; Pynod; Nalp10; Napl10; 6430548I20Rik
Summary: Predicted to enable ATP hydrolysis activity and GTPase activity. Involved in defense response to fungus; positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; and positive regulation of inflammatory response. Predicted to be located in cytoplasmic side of plasma membrane; cytosol; and nucleus. Predicted to be active in cytoplasm. Is expressed in back skin. Orthologous to human NLRP10 (NLR family pyrin domain containing 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in heart adult (RPKM 3.9), ovary adult (RPKM 0.7) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 E3; 7 57.21 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (108521060..108529365, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (108921853..108930158, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NLRP10 ablation protects against ischemia/reperfusion-associated brain injury by suppression of neuroinflammation.
Title: NLRP10 ablation protects against ischemia/reperfusion-associated brain injury by suppression of neuroinflammation.
this study shows that NLRP10 affects the stability of Abin-1 to control inflammatory responses
Title: NLRP10 Affects the Stability of Abin-1 To Control Inflammatory Responses.
Authors observed an important role of NLRP10 in cytokine and chemokine production as well as expression of NF-kappaB and MAPKs in CSE-exposed A549 cells. Furthermore, replenishment of A549 cell culture with recombinant IL-17A (rIL-17A) during NLRP10 knockdown rescued CSE-induced inflammatory responses.
Title: Cigarette smoke-induced inflammation: NLRP10-mediated mechanisms.
this study documented a role for NLRP10 as a suppressor of the cutaneous inflammatory response to Leishmania major infection
Title: An Anti-Inflammatory Role for NLRP10 in Murine Cutaneous Leishmaniasis.
NLRP10 contributes to T-cell-mediated inflammatory responses in the skin
Title: Epidermal NLRP10 contributes to contact hypersensitivity responses in mice.
conclude that DOCK8 is an important regulator of DC migration during an immune response and is prone to mutations that disrupt its crucial function
Title: Coincidental loss of DOCK8 function in NLRP10-deficient and C3H/HeJ mice results in defective dendritic cell migration.
Review summarize recent advances of the role of of human and murine NLRP10 in innate and adaptive immune responses. [Review]
Title: Roles of NLRP10 in innate and adaptive immunity.
Nlrp10-deficient mice displayed a profound defect in Candida-specific Th1 and Th17 responses. These results demonstrate a novel role for Nlrp10 in the generation of adaptive immune responses to fungal infection.
Title: Cutting edge: Nlrp10 is essential for protective antifungal adaptive immunity against Candida albicans.
loss of antigen transport to the draining lymph nodes by a subset of migratory dendritic cells resulted in an almost absolute loss in naive CD4( ) T-cell priming, highlighting the critical link between diverse innate immune stimulation, NLRP10 activity and the immune function of mature DCs
Title: NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells.
Serum interleukin (IL)-1beta and TNF-alpha after lipopolysaccharide injection are decreased in PYNOD-transgenic and apoptosis-associated speck-like protein containing a caspase recruitment domain knockout mice compared with those of wild-type mice.
Title: Anti-inflammatory activity of PYNOD and its mechanism in humans and mice.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI592968 (e-PCR)
- UniSTS:208185

Nlrp10 (e-PCR), detects polymorphism
- UniSTS:502668

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info
enables ATP hydrolysis activity	ISS Inferred from Sequence or Structural Similarity more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in activation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in activation of innate immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within defense response	RCA inferred from Reviewed Computational Analysis more info	PubMed
involved_in defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T-helper 1 type immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of T-helper 17 type immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of defense response to bacterium	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-1 alpha production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 alpha production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: NACHT, LRR and PYD domains-containing protein 10

Names: NACHT, LRR and PYD containing protein 10; NACHT, leucine rich repeat and PYD containing 10; NACHT/LRR/pyrin domain-containing protein 10; neuronal apoptosis inhibitor protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175532.3 → NP_780741.1 NACHT, LRR and PYD domains-containing protein 10

See identical proteins and their annotated locations for NP_780741.1

Status: VALIDATED

Source sequence(s)

AC122046, AK028575

Consensus CDS

CCDS21730.1

UniProtKB/Swiss-Prot

Q8CCN1

UniProtKB/TrEMBL

Q3V3Z6, Q6JGS9

Related

ENSMUSP00000050252.4, ENSMUST00000055745.5

Conserved Domains (3) summary

smart00382
Location:161 → 298

AAA; ATPases associated with a variety of cellular activities

cd08321
Location:10 → 88

Pyrin_ASC-like; Pyrin Death Domain found in ASC

pfam05729
Location:165 → 316

NACHT; NACHT domain