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    Manf mesencephalic astrocyte-derived neurotrophic factor [ Mus musculus (house mouse) ]

    Gene ID: 74840, updated on 27-Nov-2024

    Summary

    Official Symbol
    Manfprovided by MGI
    Official Full Name
    mesencephalic astrocyte-derived neurotrophic factorprovided by MGI
    Primary source
    MGI:MGI:1922090
    See related
    Ensembl:ENSMUSG00000032575 AllianceGenome:MGI:1922090
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Armet; D18Mgi17; 3230402M22Rik
    Summary
    Predicted to enable sulfatide binding activity. Acts upstream of or within vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure. Predicted to be located in endoplasmic reticulum lumen and perinuclear region of cytoplasm. Predicted to be active in endoplasmic reticulum and extracellular space. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in Parkinsonism; breast cancer; carcinoma (multiple); and pancreatic cancer. Orthologous to human MANF (mesencephalic astrocyte derived neurotrophic factor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 52.6), testis adult (RPKM 26.4) and 26 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Manf in Genome Data Viewer
    Location:
    9 F1; 9 57.98 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (106765952..106769137, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (106888753..106891938, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_25160 Neighboring gene RAD54 like 2 (S. cerevisiae) Neighboring gene STARR-seq mESC enhancer starr_25163 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:106723938-106724121 Neighboring gene STARR-positive B cell enhancer ABC_E8313 Neighboring gene DDB1 and CUL4 associated factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E9334 Neighboring gene STARR-positive B cell enhancer ABC_E460 Neighboring gene RNA binding motif protein 15B Neighboring gene dedicator of cyto-kinesis 3 Neighboring gene predicted gene, 18542 Neighboring gene STARR-seq mESC enhancer starr_25166 Neighboring gene pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 3 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables sulfatide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables sulfatide binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum lumen ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sarcoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    mesencephalic astrocyte-derived neurotrophic factor
    Names
    arginine-rich protein
    arginine-rich, mutated in early stage tumors

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029103.4NP_083379.2  mesencephalic astrocyte-derived neurotrophic factor precursor

      See identical proteins and their annotated locations for NP_083379.2

      Status: VALIDATED

      Source sequence(s)
      AK131997
      Consensus CDS
      CCDS23486.1
      UniProtKB/Swiss-Prot
      Q3TMX5, Q9CXI5
      UniProtKB/TrEMBL
      A8C1V1
      Related
      ENSMUSP00000124562.2, ENSMUST00000159283.8
      Conserved Domains (1) summary
      pfam10208
      Location:26170
      Armet; Degradation arginine-rich protein for mis-folding

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      106765952..106769137 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)