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    Slc9b2 solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2 [ Mus musculus (house mouse) ]

    Gene ID: 97086, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc9b2provided by MGI
    Official Full Name
    solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2provided by MGI
    Primary source
    MGI:MGI:2140077
    See related
    Ensembl:ENSMUSG00000037994 AllianceGenome:MGI:2140077
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NHA2; NHE10; nhaoc; Nhedc2; nha-oc
    Summary
    Predicted to enable identical protein binding activity; lithium:proton antiporter activity; and sodium:proton antiporter activity. Involved in several processes, including flagellated sperm motility; regulation of insulin secretion involved in cellular response to glucose stimulus; and sodium ion homeostasis. Acts upstream of or within positive regulation of osteoclast development. Located in several cellular components, including basolateral plasma membrane; cytoplasmic vesicle; and sperm principal piece. Is expressed in alimentary system; brain; femur; male reproductive gland or organ; and mesenteric adipose tissue. Orthologous to human SLC9B2 (solute carrier family 9 member B2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Slc9b2 in Genome Data Viewer
    Location:
    3 G3; 3 62.55 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (135013083..135048606)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (135307651..135342845)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8965 Neighboring gene centromere protein E Neighboring gene predicted gene, 46826 Neighboring gene 3-hydroxybutyrate dehydrogenase, type 2 Neighboring gene STARR-seq mESC enhancer starr_09056 Neighboring gene STARR-seq mESC enhancer starr_09057 Neighboring gene STARR-seq mESC enhancer starr_09058 Neighboring gene solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:135065430-135065659 Neighboring gene CDGSH iron sulfur domain 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (2) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lithium:proton antiporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables lithium:proton antiporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables sodium:proton antiporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables sodium:proton antiporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
     
    NOT located_in mitochondrial membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in recycling endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in recycling endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in sperm principal piece IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    sodium/hydrogen exchanger 9B2
    Names
    NHE domain-containing protein 2
    Na(+)/H(+) exchanger NHA2
    Na(+)/H(+) exchanger-like domain-containing protein 2
    Na+/H+ exchanger domain containing 2
    mitochondrial Na(+)/H(+) exchanger NHA2
    mitochondrial sodium/hydrogen exchanger 9B2
    mitochondrial sodium/hydrogen exchanger NHA2
    soditlum/hydrogen exchanger-like domain-containing protein 2
    sodium/hydrogen exchanger-like domain-containing protein 2
    solute carrier family 9 subfamily B member 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411266.1NP_001398195.1  sodium/hydrogen exchanger 9B2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC104874
    2. NM_001411267.1NP_001398196.1  sodium/hydrogen exchanger 9B2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC104874
      Related
      ENSMUST00000126034.4
    3. NM_178877.7NP_849208.4  sodium/hydrogen exchanger 9B2 isoform 1

      See identical proteins and their annotated locations for NP_849208.4

      Status: VALIDATED

      Source sequence(s)
      AC104874
      Consensus CDS
      CCDS17854.1
      UniProtKB/Swiss-Prot
      Q5BKR2, Q8CA47, Q8CDX4
      Related
      ENSMUSP00000060640.8, ENSMUST00000051849.10
      Conserved Domains (1) summary
      cl01133
      Location:176534
      Na_H_Exchanger; Sodium/hydrogen exchanger family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      135013083..135048606
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163428.1XP_036019321.1  sodium/hydrogen exchanger 9B2 isoform X3

      Conserved Domains (1) summary
      cl01133
      Location:84442
      Na_H_Exchanger; Sodium/hydrogen exchanger family
    2. XM_030252930.1XP_030108790.1  sodium/hydrogen exchanger 9B2 isoform X4

      Conserved Domains (1) summary
      cl01133
      Location:18285
      Na_H_Exchanger; Sodium/hydrogen exchanger family
    3. XM_006502400.5XP_006502463.1  sodium/hydrogen exchanger 9B2 isoform X2

      Conserved Domains (1) summary
      cl01133
      Location:176534
      Na_H_Exchanger; Sodium/hydrogen exchanger family
    4. XM_006502398.3XP_006502461.1  sodium/hydrogen exchanger 9B2 isoform X1

      See identical proteins and their annotated locations for XP_006502461.1

      UniProtKB/Swiss-Prot
      Q5BKR2, Q8CA47, Q8CDX4
      Conserved Domains (1) summary
      cl01133
      Location:176534
      Na_H_Exchanger; Sodium/hydrogen exchanger family
    5. XM_006502402.3XP_006502465.1  sodium/hydrogen exchanger 9B2 isoform X4

      Conserved Domains (1) summary
      cl01133
      Location:18285
      Na_H_Exchanger; Sodium/hydrogen exchanger family
    6. XM_006502399.3XP_006502462.1  sodium/hydrogen exchanger 9B2 isoform X1

      See identical proteins and their annotated locations for XP_006502462.1

      UniProtKB/Swiss-Prot
      Q5BKR2, Q8CA47, Q8CDX4
      Conserved Domains (1) summary
      cl01133
      Location:176534
      Na_H_Exchanger; Sodium/hydrogen exchanger family
    7. XM_030252931.1XP_030108791.1  sodium/hydrogen exchanger 9B2 isoform X4

      Conserved Domains (1) summary
      cl01133
      Location:18285
      Na_H_Exchanger; Sodium/hydrogen exchanger family
    8. XM_036163430.1XP_036019323.1  sodium/hydrogen exchanger 9B2 isoform X4

      Conserved Domains (1) summary
      cl01133
      Location:18285
      Na_H_Exchanger; Sodium/hydrogen exchanger family
    9. XM_036163431.1XP_036019324.1  sodium/hydrogen exchanger 9B2 isoform X4

      Conserved Domains (1) summary
      cl01133
      Location:18285
      Na_H_Exchanger; Sodium/hydrogen exchanger family