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    Yy2 Yy2 transcription factor [ Mus musculus (house mouse) ]

    Gene ID: 100073351, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Yy2provided by MGI
    Official Full Name
    Yy2 transcription factorprovided by MGI
    Primary source
    MGI:MGI:3837947
    See related
    Ensembl:ENSMUSG00000091736 AllianceGenome:MGI:3837947
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in chromatin and nucleus. Predicted to be part of PcG protein complex and transcription regulator complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver. Orthologous to human YY2 (YY2 transcription factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human all
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    Genomic context

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    See Yy2 in Genome Data Viewer
    Location:
    X F4; X 72.57 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (156349115..156351981, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (157566119..157568985, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene mitochondrial import receptor subunit TOM5 homolog Neighboring gene STARR-seq mESC enhancer starr_48153 Neighboring gene DnaJ (Hsp40) homolog, subfamily B, member 9 pseudogene Neighboring gene membrane-bound transcription factor peptidase, site 2 Neighboring gene STARR-seq mESC enhancer starr_48154 Neighboring gene STARR-seq mESC enhancer starr_48156 Neighboring gene STARR-positive B cell enhancer ABC_E7709 Neighboring gene STARR-seq mESC enhancer starr_48157 Neighboring gene predicted gene 15173 Neighboring gene STARR-seq mESC enhancer starr_48159 Neighboring gene protein Hikeshi pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcription factor Yin-Yang 2 alters neuronal outgrowth in vitro. Klar M, et al. Cell Tissue Res, 2015 Nov. PMID 26350623, Free PMC Article
    2. Role of polypyrimidine tract-binding protein 1/yin yang 2 signaling in regulating vascular smooth muscle cell proliferation and neointima hyperplasia. Wang Z, et al. Toxicol Appl Pharmacol, 2019 Nov 15. PMID 31499192
    3. Control of embryonic stem cell self-renewal and differentiation via coordinated alternative splicing and translation of YY2. Tahmasebi S, et al. Proc Natl Acad Sci U S A, 2016 Nov 1. PMID 27791185, Free PMC Article
    4. Developmental expression profile of the YY2 gene in mice. Drews D, et al. BMC Dev Biol, 2009 Jul 28. PMID 19638226, Free PMC Article
    5. Retroposition and evolution of the DNA-binding motifs of YY1, YY2 and REX1. Kim JD, et al. Nucleic Acids Res, 2007. PMID 17478514, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PTBP1 is a critical regulator of vascular smooth muscle cell proliferation and neointima hyperplasia via modulating the expression of YY2.
      Title: Role of polypyrimidine tract-binding protein 1/yin yang 2 signaling in regulating vascular smooth muscle cell proliferation and neointima hyperplasia.
    2. in a transplantation mouse model of liver metastases, expression of Yy2 (and therefore of Aes) is downregulated
      Title: Expression of metastasis suppressor gene AES driven by a Yin Yang (YY) element in a CpG island promoter and transcription factor YY2.
    3. both the up- and down-regulation of yy2 significantly impairs the outgrowth of the major neurite of primary hippocampal neurons and the numbers of neuronal processes in proximate extensions
      Title: Transcription factor Yin-Yang 2 alters neuronal outgrowth in vitro.
    4. Yy2 expression in the heart and lung is constitutively expressed during embryogenesis and in adult mice. Developmental changes of yy2 transcription became obvious in various areas of the brain.
      Title: Developmental expression profile of the YY2 gene in mice.
    5. the novel factor YY2 antagonizes the negative actions exerted by YY1
      Title: Enhanceosome formation over the beta interferon promoter underlies a remote-control mechanism mediated by YY1 and YY2.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of PcG protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor YY2
    Names
    YY-2
    yin and yang 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098723.1 → NP_001092193.1  transcription factor YY2

      See identical proteins and their annotated locations for NP_001092193.1

      Status: VALIDATED

      Source sequence(s)
      AK161451
      Consensus CDS
      CCDS53233.1
      UniProtKB/Swiss-Prot
      Q3TTC2, Q8CBG3
      Related
      ENSMUSP00000070112.5, ENSMUST00000065806.5
      Conserved Domains (4) summary
      COG5048
      Location:289 → 378
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:291 → 311
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:289 → 311
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:333 → 360
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      156349115..156351981 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TTC2.1 GenPept UniProtKB/Swiss-Prot:Q3TTC2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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