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    HXT17 hexose transporter HXT17 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855809, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HXT17
    Official Full Name
    hexose transporter HXT17
    Primary source
    SGD:S000005355
    Locus tag
    YNR072W
    See related
    AllianceGenome:SGD:S000005355; FungiDB:YNR072W; VEuPathDB:YNR072W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    HLT4
    Summary
    Enables D-glucose transmembrane transporter activity; fructose transmembrane transporter activity; and mannose transmembrane transporter activity. Involved in hexose transmembrane transport; mannitol transmembrane transport; and sorbitol transmembrane transport. Located in cell periphery and fungal-type vacuole. Orthologous to human SLC2A6 (solute carrier family 2 member 6) and SLC2A8 (solute carrier family 2 member 8). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See HXT17 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (772657..774351)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette multidrug transporter PDR18 Neighboring gene aldose 1-epimerase superfamily protein Neighboring gene putative mannitol dehydrogenase Neighboring gene Aif1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression of the HXT13, HXT15 and HXT17 genes in Saccharomyces cerevisiae and stabilization of the HXT1 gene transcript by sugar-induced osmotic stress. Greatrix BW, et al. Curr Genet, 2006 Apr. PMID 16397765
    2. Hxt13, Hxt15, Hxt16 and Hxt17 from Saccharomyces cerevisiae represent a novel type of polyol transporters. Jordan P, et al. Sci Rep, 2016 Mar 21. PMID 26996892, Free PMC Article
    3. Arsenic trioxide uptake by hexose permeases in Saccharomyces cerevisiae. Liu Z, et al. J Biol Chem, 2004 Apr 23. PMID 14966117
    4. Uptake of radiolabeled GlcNAc into Saccharomyces cerevisiae via native hexose transporters and its in vivo incorporation into GPI precursors in cells expressing heterologous GlcNAc kinase. Scarcelli JJ, et al. FEMS Yeast Res, 2012 May. PMID 22151002, Free PMC Article
    5. Concurrent knock-out of at least 20 transporter genes is required to block uptake of hexoses in Saccharomyces cerevisiae. Wieczorke R, et al. FEBS Lett, 1999 Dec 31. PMID 10618490

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables D-glucose transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables carbohydrate:proton symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fructose transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables mannose transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fructose transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hexose transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mannitol transmembrane transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mannose transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sorbitol transmembrane transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in fungal-type vacuole HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    hexose transporter HXT17
    NP_014470.1
    • Putative transmembrane polyol transporter; supports growth on and uptake of mannitol and sorbitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; induced by raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose; HXT17 has a paralog, HXT13, that arose from a segmental duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      772657..774351
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183249.1 → NP_014470.1  TPA: hexose transporter HXT17 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014470.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1P7, P53631
      UniProtKB/TrEMBL
      A6ZSE6, C8ZFU9
      Conserved Domains (1) summary
      pfam00083
      Location:60 → 521
      Sugar_tr; Sugar (and other) transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53631.1

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