Klkb1 kallikrein B, plasma 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Klkb1provided by MGI
Official Full Name: kallikrein B, plasma 1provided by MGI
Primary source: MGI:MGI:102849
See related: Ensembl:ENSMUSG00000109764 AllianceGenome:MGI:102849
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: APS; PSA; Kal3; Klk3; Kal-3
Summary: This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic processing to generate a disulfide-linked heterodimeric enzyme comprised of heavy and light chains. A complete deletion of the encoded protein prevents occlusive thrombus formation in mice with a minimal role in provoked bleeding. [provided by RefSeq, May 2016]
Expression: Biased expression in liver adult (RPKM 26.3), liver E18 (RPKM 18.5) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 B1.1; 8 25.17 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (45719725..45747872, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (45266688..45294835, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ablation of Plasma Prekallikrein Decreases Low-Density Lipoprotein Cholesterol by Stabilizing Low-Density Lipoprotein Receptor and Protects Against Atherosclerosis.
Title: Ablation of Plasma Prekallikrein Decreases Low-Density Lipoprotein Cholesterol by Stabilizing Low-Density Lipoprotein Receptor and Protects Against Atherosclerosis.
Circulating PKK confines pro-inflammatory signaling in the lung by a mechanism that does not involve contact system activation, which in the case of respiratory tract infection may impede early protective innate immunity.
Title: Prekallikrein inhibits innate immune signaling in the lung and impairs host defense during pneumosepsis in mice.
In ambient particulate matter-induced lung injury model, Klkb1(-/-) mice exhibited a decrease in total protein, cells numbers in bronchoalveolar lavage fluid (BALF) and histologic lung injury score. The TNF-alpha and IL-6 levels in BALF were significantly decreased in ambient particulate matter-treated Klkb1(-/-) mice.
Title: Plasma kallikrein contributes to ambient particulate matter-induced lung injury.
Plasma kallikrein is detected in the urine of proteinuria and activates ENaC involving the putative prostasin cleavage site. However, PKLK is not essential for volume retention in nephrotic mice.
Title: Plasma kallikrein activates the epithelial sodium channel in vitro but is not essential for volume retention in nephrotic mice.
Determination of the crystal structures of a serine protease, murine plasma kallikrein.
Title: Crystal structure of plasma kallikrein reveals the unusual flexibility of the S1 pocket triggered by Glu217.
Plasma kallikrein-dependent activation of latent TGF-beta in the acute liver injury.
Title: Prevention of acute liver injury by suppressing plasma kallikrein-dependent activation of latent TGF-β.
Plasma kallikrein mediates brain hemorrhage and edema caused by tissue plasminogen activator therapy in mice after stroke.
Title: Plasma kallikrein mediates brain hemorrhage and edema caused by tissue plasminogen activator therapy in mice after stroke.
we found that post-ejaculated semen from fertile wild-type males was solidified and the sperm were entrapped in Wnt7aCre/+;Esr1f/f uteri, compared to the watery semen (liquefied) found in Esr1f/f controls.Kallikrein-related peptidases 3 (KLK3) and other kallikrein-related peptidases from male prostate glands are responsible for semen liquefaction by cleaving gel-forming proteins
Title: Crucial role of estrogen for the mammalian female in regulating semen coagulation and liquefaction in vivo.
Klkb1(-/-) mice have a novel mechanism for thrombosis protection in addition to reduced contact activation. This pathway arises when bradykinin delivery to vasculature is compromised and mediated by increased receptor Mas, prostacyclin, Sirt1, and KLF4
Title: Reduced thrombosis in Klkb1-/- mice is mediated by increased Mas receptor, prostacyclin, Sirt1, and KLF4 and decreased tissue factor.
Plasma kallikrein deletion prevents occlusive thrombus formation in mice with a minimal role in provoked bleeding.
Title: Effects of plasma kallikrein deficiency on haemostasis and thrombosis in mice: murine ortholog of the Fletcher trait.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M58588 (e-PCR)
- UniSTS:159760

Klkb1 (e-PCR), detects polymorphism
- UniSTS:143701

Klk3 (e-PCR)
- UniSTS:143702

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in blood coagulation	IEA Inferred from Electronic Annotation more info
involved_in fibrinolysis	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in plasminogen activation	IEA Inferred from Electronic Annotation more info
involved_in plasminogen activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibrinolysis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of fibrinolysis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: plasma kallikrein

Names: antigen, prostate specific; fletcher factor; kallikrein 3, plasma; kininogenin; plasma prekallikrein

NP_032481.2

EC 3.4.21.34

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008455.3 → NP_032481.2 plasma kallikrein preproprotein

See identical proteins and their annotated locations for NP_032481.2

Status: REVIEWED

Source sequence(s)

AC120003

Consensus CDS

CCDS22275.1

UniProtKB/Swiss-Prot

P26262, Q8R0P5

Related

ENSMUSP00000026907.6, ENSMUST00000026907.6

Conserved Domains (3) summary

smart00223
Location:21 → 104

APPLE; APPLE domain

smart00020
Location:390 → 621

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:391 → 621

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...