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    GAL10 bifunctional UDP-glucose 4-epimerase/aldose 1-epimerase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852307, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GAL10
    Official Full Name
    bifunctional UDP-glucose 4-epimerase/aldose 1-epimerase
    Primary source
    SGD:S000000223
    Locus tag
    YBR019C
    See related
    AllianceGenome:SGD:S000000223; FungiDB:YBR019C; VEuPathDB:YBR019C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables UDP-glucose 4-epimerase activity and aldose 1-epimerase activity. Involved in galactose catabolic process via UDP-galactose. Located in cytosol. Used to study galactosemia and thrombocytopenia. Human ortholog(s) of this gene implicated in galactose epimerase deficiency; galactosemia; and thrombocytopenia. Orthologous to human GALE (UDP-galactose-4-epimerase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See GAL10 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (276253..278352, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Kap104p Neighboring gene UDP-glucose:hexose-1-phosphate uridylyltransferase Neighboring gene ncRNA Neighboring gene galactokinase Neighboring gene uracil permease

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Relationship between UDP-galactose 4'-epimerase activity and galactose sensitivity in yeast. Wasilenko J, et al. J Biol Chem, 2006 Mar 31. PMID 16452467
    2. The molecular architecture of galactose mutarotase/UDP-galactose 4-epimerase from Saccharomyces cerevisiae. Thoden JB, et al. J Biol Chem, 2005 Jun 10. PMID 15795221
    3. Purification and characterization of the yeast transcriptional activator GAL4. Parthun MR, et al. J Biol Chem, 1990 Jan 5. PMID 2403556
    4. Statistical positioning of nucleosomes by specific protein-binding to an upstream activating sequence in yeast. Fedor MJ, et al. J Mol Biol, 1988 Nov 5. PMID 3063825
    5. Characterization of the Saccharomyces cerevisiae galactose mutarotase/UDP-galactose 4-epimerase protein, Gal10p. Scott A, et al. FEMS Yeast Res, 2007 May. PMID 17253981

    See all (95) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We suggest that GAL10-ncRNA tunes the expression of GAL genes by additional mechanisms besides suppressing leaky transcription from the GAL1-10 promoter.
      Title: A novel CRE recombinase assay for quantification of GAL10-non coding RNA suppression on transcriptional leakage.
    2. NuA4 Histone Acetyltransferase associates with the GAL10 antisense transcription initiation site at the 3' end of the coding sequence.
      Title: Regulation of Antisense Transcription by NuA4 Histone Acetyltransferase and Other Chromatin Regulatory Factors.
    3. RNA polymerase II is targeted to the antisense initiation site at GAL10 by Reb1p activator as well as general transcription factors (e.g., TFIID, TFIIB, and Mediator) for antisense transcription initiation.
      Title: Mechanisms of antisense transcription initiation from the 3' end of the GAL10 coding sequence in vivo.
    4. quantitative relationship between galactokinase activity, gal-1P accumulation, and growth arrest of galactose-challenged GALT or GALE-deficiency
      Title: Distinct roles of galactose-1P in galactose-mediated growth arrest of yeast deficient in galactose-1P uridylyltransferase (GALT) and UDP-galactose 4'-epimerase (GALE).
    5. molecular amalysis of galactose mutarotase/UDP-galactose 4-epimerase from Saccharomyces cerevisiae
      Title: The molecular architecture of galactose mutarotase/UDP-galactose 4-epimerase from Saccharomyces cerevisiae.
    6. The epimerase and mutarotase activities do not appear to influence each other. Protein is a dimer in solution.
      Title: Characterization of the Saccharomyces cerevisiae galactose mutarotase/UDP-galactose 4-epimerase protein, Gal10p.
    7. The 3-dimensional structure of the dual-function enzyme Gal10p was determined at 1.85-Angstrom resolution. It folds into 2 separate and distinct units (corresponding to the epimerase and mutarotase domains) that are connected by a simple Type II turn.
      Title: The molecular architecture of galactose mutarotase/UDP-galactose 4-epimerase from Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables UDP-glucose 4-epimerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-glucose 4-epimerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP-glucose 4-epimerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables UDP-glucose 4-epimerase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables aldose 1-epimerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aldose 1-epimerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in galactose catabolic process via UDP-galactose IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in galactose catabolic process via UDP-galactose IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in galactose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hexose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monosaccharide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    bifunctional UDP-glucose 4-epimerase/aldose 1-epimerase
    NP_009575.1
    • UDP-glucose-4-epimerase; catalyzes interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers; human homolog GALE implicated in galactosemia, can complement yeast null mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      276253..278352 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178367.1 → NP_009575.1  TPA: bifunctional UDP-glucose 4-epimerase/aldose 1-epimerase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009575.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQ21, P04397, Q05765
      UniProtKB/TrEMBL
      A6ZKW5, B3LNC2, B5VDY8, C7GM33, C8Z413
      Conserved Domains (2) summary
      cd09019
      Location:376 → 698
      galactose_mutarotase_like; galactose mutarotase_like
      cd05247
      Location:14 → 349
      UDP_G4E_1_SDR_e; UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P04397.2

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