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    FUR4 uracil permease [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852309, updated on 9-Dec-2024

    Summary

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    Official Symbol
    FUR4
    Official Full Name
    uracil permease
    Primary source
    SGD:S000000225
    Locus tag
    YBR021W
    See related
    AllianceGenome:SGD:S000000225; FungiDB:YBR021W; VEuPathDB:YBR021W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables uracil:monoatomic cation symporter activity. Involved in transmembrane transport and uracil transport. Located in eisosome and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See FUR4 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (281443..283344)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene bifunctional UDP-glucose 4-epimerase/aldose 1-epimerase Neighboring gene galactokinase Neighboring gene ADP-ribose 1''-phosphate phosphatase Neighboring gene chitin synthase CHS3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Primary structure of the uracil transport protein of Saccharomyces cerevisiae. Jund R, et al. Eur J Biochem, 1988 Jan 15. PMID 3276521
    2. Genetic and physiological aspects of resistance to 5-fluoropyrimidines in Saccharomyces cerevisiae. Jund R, et al. J Bacteriol, 1970 Jun. PMID 5429721, Free PMC Article
    3. Uracil-induced down-regulation of the yeast uracil permease. Séron K, et al. J Bacteriol, 1999 Mar. PMID 10074071, Free PMC Article
    4. Cloning and transcriptional control of a eucaryotic permease gene. Chevallier MR. Mol Cell Biol, 1982 Aug. PMID 6290876, Free PMC Article
    5. The yeast plasma membrane uracil permease is stabilized against stress induced degradation by a point mutation in a cyclin-like "destruction box". Galan JM, et al. Biochem Biophys Res Commun, 1994 Jun 15. PMID 8003013

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Plasma membrane tension regulates eisosome structure and function.
      Title: Plasma membrane tension regulates eisosome structure and function.
    2. Conformation-sensing domain regulates Fur4 substrate-dependent degradation.
      Title: Quality control and substrate-dependent downregulation of the nutrient transporter Fur4.
    3. GPI-anchored proteins are required for the recruitment of membrane proteins Tat2p and Fur4p to the plasma membrane via detergent-resistant membranes.
      Title: Glycosylphosphatidylinositol-anchored proteins are required for the transport of detergent-resistant microdomain-associated membrane proteins Tat2p and Fur4p.
    4. During heat stress, sphingolipids signal turnover of the uracil permease, Fur4.
      Title: Slm1 and slm2 are novel substrates of the calcineurin phosphatase required for heat stress-induced endocytosis of the yeast uracil permease.
    5. analysis of long-term stability of the subdomains of Can1p: Fur4p (another H+ symporter) and Sur7p (a protein of unknown function) occupy the Can1p subdomain
      Title: Distribution of Can1p into stable domains reflects lateral protein segregation within the plasma membrane of living S. cerevisiae cells.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables nucleobase transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables uracil:monoatomic cation symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nucleobase transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in uracil transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in uracil transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in eisosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fungal-type vacuole HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uracil permease
    NP_009577.1
    • Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate binding result in Rsp5p-mediated ubiquitination and degradation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      281443..283344
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178369.1 → NP_009577.1  TPA: uracil permease [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009577.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQ23, P05316
      UniProtKB/TrEMBL
      A6ZKW7, B3LNC0, B5VDZ0, C7GM31, C8Z415, N1P9C3
      Conserved Domains (1) summary
      cd11482
      Location:96 → 580
      SLC-NCS1sbd_NRT1-like; nucleobase-cation-symport-1 (NCS1) transporter NRT1-like; solute-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P05316.2

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