Tnpo3 transportin 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tnpo3provided by MGI
Official Full Name: transportin 3provided by MGI
Primary source: MGI:MGI:1196412
See related: Ensembl:ENSMUSG00000012535 AllianceGenome:MGI:1196412
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Trn-SR; mKIAA4133; D6Ertd313e; 5730544L10Rik; C430013M08Rik
Summary: Predicted to enable identical protein binding activity and small GTPase binding activity. Predicted to be involved in protein import into nucleus. Predicted to be located in annulate lamellae and nuclear envelope. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in autosomal dominant limb-girdle muscular dystrophy type 2. Orthologous to human TNPO3 (transportin 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 24.3), placenta adult (RPKM 20.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 A3.3; 6 12.36 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (29540826..29609918, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (29540827..29609858, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tnpo3 enables EBF1 function in conditions of antagonistic Notch signaling.
Title: Tnpo3 enables EBF1 function in conditions of antagonistic Notch signaling.
Morphological study of TNPO3 and SRSF1 interaction during myogenesis by combining confocal, structured illumination and electron microscopy analysis.
Title: Morphological study of TNPO3 and SRSF1 interaction during myogenesis by combining confocal, structured illumination and electron microscopy analysis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D6Ertd313e (e-PCR), detects polymorphism
- UniSTS:167476

RH135988 (e-PCR)
- UniSTS:209984

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

RH127018 (e-PCR)
- UniSTS:209775

AU049162 (e-PCR)
- UniSTS:145610

RH141220 (e-PCR)
- UniSTS:223216

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in protein import into nucleus	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in annulate lamellae	ISO Inferred from Sequence Orthology more info
located_in annulate lamellae	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: transportin-3

Names: transportin-SR

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347079.2 → NP_001334008.1 transportin-3 isoform 2

Status: VALIDATED

Source sequence(s)

AC079276

Consensus CDS

CCDS85023.1

UniProtKB/TrEMBL

Q6DI95

Related

ENSMUSP00000110906.2, ENSMUST00000115251.8
NM_001361290.1 → NP_001348219.1 transportin-3 isoform 3

Status: VALIDATED

Source sequence(s)

AC079276

UniProtKB/TrEMBL

Q6DI95

Conserved Domains (1) summary

pfam08389
Location:54 → 182

Xpo1; Exportin 1-like protein
NM_177296.5 → NP_796270.2 transportin-3 isoform 1

See identical proteins and their annotated locations for NP_796270.2

Status: VALIDATED

Source sequence(s)

AC079276

Consensus CDS

CCDS19963.1

UniProtKB/Swiss-Prot

Q6P2B1, Q7TSL6, Q8BKX4, Q8BP42

UniProtKB/TrEMBL

Q6DI95

Related

ENSMUSP00000012679.9, ENSMUST00000012679.15

Conserved Domains (2) summary

smart00913
Location:33 → 96

IBN_N; Importin-beta N-terminal domain

pfam08389
Location:120 → 248

Xpo1; Exportin 1-like protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

29540826..29609918 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006505121.5 → XP_006505184.1 transportin-3 isoform X3

UniProtKB/TrEMBL

Q6DI95

Conserved Domains (1) summary

pfam08389
Location:55 → 182

Xpo1; Exportin 1-like protein
XM_030255468.2 → XP_030111328.1 transportin-3 isoform X1

UniProtKB/TrEMBL

Q6DI95

Conserved Domains (2) summary

smart00913
Location:8 → 62

IBN_N; Importin-beta N-terminal domain

pfam08389
Location:86 → 214

Xpo1; Exportin 1-like protein
XM_030255469.1 → XP_030111329.1 transportin-3 isoform X2

UniProtKB/TrEMBL

Q6DI95

Conserved Domains (2) summary

smart00913
Location:8 → 62

IBN_N; Importin-beta N-terminal domain

pfam08389
Location:86 → 214

Xpo1; Exportin 1-like protein
XM_030255470.1 → XP_030111330.1 transportin-3 isoform X4

UniProtKB/TrEMBL

Q6DI95

Conserved Domains (1) summary

pfam08389
Location:54 → 182

Xpo1; Exportin 1-like protein
XM_036166242.1 → XP_036022135.1 transportin-3 isoform X3

UniProtKB/TrEMBL

Q6DI95

Conserved Domains (1) summary

pfam08389
Location:55 → 182

Xpo1; Exportin 1-like protein
XM_036166243.1 → XP_036022136.1 transportin-3 isoform X3

UniProtKB/TrEMBL

Q6DI95

Conserved Domains (1) summary

pfam08389
Location:55 → 182

Xpo1; Exportin 1-like protein