Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hadhbprovided by MGI
Official Full Name: hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit betaprovided by MGI
Primary source: MGI:MGI:2136381
See related: Ensembl:ENSMUSG00000059447 AllianceGenome:MGI:2136381
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mtpb; TP-beta; 4930479F15Rik
Summary: Enables acetyl-CoA C-acetyltransferase activity and lncRNA binding activity. Involved in cellular response to lipopolysaccharide and gene expression. Located in mitochondrial inner membrane. Is active in mitochondrion. Is expressed in heart; liver; and placenta. Human ortholog(s) of this gene implicated in mitochondrial metabolism disease and mitochondrial trifunctional protein deficiency. Orthologous to human HADHB (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in heart adult (RPKM 131.2), liver E18 (RPKM 32.5) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 B1; 5 16.04 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (30360251..30389591)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (30155253..30184593)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A long noncoding RNA regulates inflammation resolution by mouse macrophages through fatty acid oxidation activation.
Title: A long noncoding RNA regulates inflammation resolution by mouse macrophages through fatty acid oxidation activation.
nonstructural protein 5 (NS5) interacted with hydroxyacyl-CoA dehydrogenase alpha and beta subunits, two components of the mitochondrial trifunctional protein (MTP) involved in LCFA beta-oxidation
Title: Japanese encephalitis virus nonstructural protein NS5 interacts with mitochondrial trifunctional protein and impairs fatty acid β-oxidation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (4)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

Hadhb (e-PCR), detects polymorphism
- UniSTS:546814

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acetyl-CoA C-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetyl-CoA C-acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables acetyl-CoA C-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables acetyl-CoA C-acyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables acetyl-CoA C-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables acetyl-CoA C-myristoyltransferase activity	IEA Inferred from Electronic Annotation more info
enables lncRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty acid beta-oxidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid beta-oxidation	IEA Inferred from Electronic Annotation more info
involved_in fatty acid beta-oxidation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fatty acid beta-oxidation	TAS Traceable Author Statement more info	PubMed
involved_in gene expression	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
part_of mitochondrial fatty acid beta-oxidation multienzyme complex	IBA Inferred from Biological aspect of Ancestor more info
part_of mitochondrial fatty acid beta-oxidation multienzyme complex	IC Inferred by Curator more info	PubMed
part_of mitochondrial fatty acid beta-oxidation multienzyme complex	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	HDA more info	PubMed
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial nucleoid	IEA Inferred from Electronic Annotation more info
located_in mitochondrial nucleoid	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: trifunctional enzyme subunit beta, mitochondrial

Names: hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta aubunit; hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit

NP_001276727.1

EC 2.3.1.155

EC 2.3.1.16

NP_001276728.1

EC 2.3.1.155

EC 2.3.1.16

NP_663533.1

EC 2.3.1.155

EC 2.3.1.16

XP_017176318.1

EC 2.3.1.155

EC 2.3.1.16

XP_036020906.1

EC 2.3.1.155

EC 2.3.1.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001289798.1 → NP_001276727.1 trifunctional enzyme subunit beta, mitochondrial precursor

See identical proteins and their annotated locations for NP_001276727.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AK033462, AK083767, BE945269, BY337615

Consensus CDS

CCDS39045.1

UniProtKB/Swiss-Prot

Q3TEH9, Q8BJI5, Q8BJM0, Q8BK52, Q99JY0

Related

ENSMUSP00000110431.2, ENSMUST00000114783.6

Conserved Domains (1) summary

cd00751
Location:56 → 472

thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...
NM_001289799.1 → NP_001276728.1 trifunctional enzyme subunit beta, mitochondrial precursor

See identical proteins and their annotated locations for NP_001276728.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AK150889, BE945269, BY337615, BY778233

Consensus CDS

CCDS39045.1

UniProtKB/Swiss-Prot

Q3TEH9, Q8BJI5, Q8BJM0, Q8BK52, Q99JY0

Related

ENSMUSP00000110434.2, ENSMUST00000114786.8

Conserved Domains (1) summary

cd00751
Location:56 → 472

thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...
NM_145558.2 → NP_663533.1 trifunctional enzyme subunit beta, mitochondrial precursor

See identical proteins and their annotated locations for NP_663533.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AK150889, BE945269, BY337615

Consensus CDS

CCDS39045.1

UniProtKB/Swiss-Prot

Q3TEH9, Q8BJI5, Q8BJM0, Q8BK52, Q99JY0

Related

ENSMUSP00000026841.9, ENSMUST00000026841.15

Conserved Domains (1) summary

cd00751
Location:56 → 472

thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

30360251..30389591

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036165013.1 → XP_036020906.1 trifunctional enzyme subunit beta, mitochondrial isoform X1

UniProtKB/Swiss-Prot

Q3TEH9, Q8BJI5, Q8BJM0, Q8BK52, Q99JY0

Conserved Domains (1) summary

cd00751
Location:56 → 472

thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...
XM_017320829.3 → XP_017176318.1 trifunctional enzyme subunit beta, mitochondrial isoform X1

UniProtKB/Swiss-Prot

Q3TEH9, Q8BJI5, Q8BJM0, Q8BK52, Q99JY0

Conserved Domains (1) summary

cd00751
Location:56 → 472

thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...