Cd300lf CD300 molecule like family member F [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd300lfprovided by MGI
Official Full Name: CD300 molecule like family member Fprovided by MGI
Primary source: MGI:MGI:2442359
See related: Ensembl:ENSMUSG00000047798 AllianceGenome:MGI:2442359
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CLM1; CLIM1; CLM-1; Digr2; IREM1; LMIR3; Pigr3; IgSF13; F730004D16Rik
Summary: Enables several functions, including interleukin-4 receptor binding activity; phosphatidylserine binding activity; and virus receptor activity. Involved in several processes, including interleukin-13-mediated signaling pathway; positive regulation of interleukin-4-mediated signaling pathway; and regulation of apoptotic cell clearance. Acts upstream of or within osteoclast differentiation. Predicted to be active in plasma membrane. Is expressed in early conceptus; embryo; and retina. Orthologous to human CD300LF (CD300 molecule like family member f). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in spleen adult (RPKM 7.7), liver E18 (RPKM 5.1) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 80.59 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (115007040..115024834, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (115116214..115135372, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Increased hippocampal excitability in miR-324-null mice.
Title: Increased hippocampal excitability in miR-324-null mice.
CD300f is a potential therapeutic target for the treatment of food allergy.
Title: CD300f is a potential therapeutic target for the treatment of food allergy.
Expression of CD300lf by microglia contributes to resistance to cerebral malaria by impeding the neuroinflammation.
Title: Expression of CD300lf by microglia contributes to resistance to cerebral malaria by impeding the neuroinflammation.
CD300LF Polymorphisms of Inbred Mouse Strains Confer Resistance to Murine Norovirus Infection in a Cell Type-Dependent Manner.
Title: CD300LF Polymorphisms of Inbred Mouse Strains Confer Resistance to Murine Norovirus Infection in a Cell Type-Dependent Manner.
Differential Lipid Recognition by Mouse versus Human CD300f, Inhibiting Passive Cutaneous Anaphylaxis, Depends on a Single Amino Acid Substitution in its Immunoglobulin-Like Domain.
Title: Differential Lipid Recognition by Mouse versus Human CD300f, Inhibiting Passive Cutaneous Anaphylaxis, Depends on a Single Amino Acid Substitution in its Immunoglobulin-Like Domain.
Loss of CD300f is associated with major depressive disorder and decreased microglial metabolic fitness.
Title: CD300f immunoreceptor is associated with major depressive disorder and decreased microglial metabolic fitness.
LMIR3-knockout neutrophils displayed significantly augmented cytotoxic activity against P. aeruginosa and C. albicans. LMIR3 expression increased in response to infection in a TLR4/MyD88-dependent manner.
Title: Mouse LIMR3/CD300f is a negative regulator of the antimicrobial activity of neutrophils.
Although the serine palmitoyltransferase complex is dispensable for the surface expression of the norovirus receptor (CD300lf), enzyme activity is required for CD300lf to adopt a conformation permissive for viral binding. Addition of extracellular ceramide to serine palmitoyltransferase-deficient cells complements both the conformational changes of CD300lf and the cellular susceptibility to murine norovirus infection.
Title: Sphingolipid biosynthesis induces a conformational change in the murine norovirus receptor and facilitates viral infection.
the ceramide-CD300f interaction inhibits neutrophil recruitment to the sites of Gram-negative bacterial skin infections in mice.
Title: Role of the Ceramide-CD300f Interaction in Gram-Negative Bacterial Skin Infections.
These findings highlight the cross-talk between IL-5 receptor and CD300f as a novel pathway regulating adipose tissue eosinophils.
Title: CD300f:IL-5 cross-talk inhibits adipose tissue eosinophil homing and subsequent IL-4 production.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (9) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11Dcr29 (e-PCR), detects polymorphism
- UniSTS:507473

D11Mit214 (e-PCR), detects polymorphism
- UniSTS:116393

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ceramide binding	IDA Inferred from Direct Assay more info	PubMed
enables ceramide binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables interleukin-4 receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylserine binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables virus receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in TRIF-dependent toll-like receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in TRIF-dependent toll-like receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in immune response-activating signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in interleukin-13-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of MyD88-dependent toll-like receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of MyD88-dependent toll-like receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic cell clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mast cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mast cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within osteoclast differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic cell clearance	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic cell clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-4-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in symbiont entry into host cell	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: CMRF35-like molecule 1

Names: CD300 antigen like family member F; CMRF-35-like molecule 1; DC-derived Ig-like receptor 2; MAIR-5; MAIR-V; leukocyte mono-Ig-like receptor 3; myeloid-associated immunoglobulin-like receptor 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001169153.1 → NP_001162624.1 CMRF35-like molecule 1 isoform 1 precursor

See identical proteins and their annotated locations for NP_001162624.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).

Source sequence(s)

AI414341, AK089313, BM227747, CK790587

Consensus CDS

CCDS48980.1

UniProtKB/Swiss-Prot

A2A6Z1, A2A6Z3, Q6PEU7, Q6SJQ7, Q8K4V9

UniProtKB/TrEMBL

A0A1C9ZQ14

Related

ENSMUSP00000102171.2, ENSMUST00000106561.8

Conserved Domains (3) summary

cd05716
Location:28 → 125

Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)

smart00410
Location:26 → 109

IG_like; Immunoglobulin like

pfam15330
Location:213 → 299

SIT; SHP2-interacting transmembrane adaptor protein, SIT
NM_001347648.1 → NP_001334577.1 CMRF35-like molecule 1 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AL606487

Consensus CDS

CCDS83925.1

UniProtKB/TrEMBL

A2A6Z2

Related

ENSMUSP00000102172.3, ENSMUST00000106562.3
NM_145634.3 → NP_663609.2 CMRF35-like molecule 1 isoform 2 precursor

See identical proteins and their annotated locations for NP_663609.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses a different splice site in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.

Source sequence(s)

AI414341, AK089313, BM227747, CK790587

Consensus CDS

CCDS25619.1

UniProtKB/Swiss-Prot

Q6SJQ7

Related

ENSMUSP00000053983.8, ENSMUST00000051264.14

Conserved Domains (2) summary

pfam15330
Location:206 → 292

SIT; SHP2-interacting transmembrane adaptor protein, SIT

cd05716
Location:24 → 125

IgV_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

115007040..115024834 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017314554.2 → XP_017170043.1 CMRF35-like molecule 1 isoform X1

Conserved Domains (2) summary

cd05716
Location:28 → 125

Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains

pfam15330
Location:191 → 277

SIT; SHP2-interacting transmembrane adaptor protein, SIT