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    Nars1 asparaginyl-tRNA synthetase 1 [ Mus musculus (house mouse) ]

    Gene ID: 70223, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Nars1provided by MGI
    Official Full Name
    asparaginyl-tRNA synthetase 1provided by MGI
    Primary source
    MGI:MGI:1917473
    See related
    Ensembl:ENSMUSG00000024587 AllianceGenome:MGI:1917473
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nars; ASNRS; 3010001M15Rik
    Summary
    Predicted to enable CCR3 chemokine receptor binding activity; asparagine-tRNA ligase activity; and protein dimerization activity. Predicted to be involved in asparaginyl-tRNA aminoacylation; cell migration; and cerebral cortex development. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human NARS1 (asparaginyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 51.7), placenta adult (RPKM 44.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nars1 in Genome Data Viewer
    Location:
    18 E1; 18 37.47 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (64632726..64649586, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (64499655..64516515, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene S-adenosylmethionine decarboxylase, pseudogene 3 Neighboring gene ferrochelatase Neighboring gene STARR-seq mESC enhancer starr_44807 Neighboring gene STARR-positive B cell enhancer ABC_E10997 Neighboring gene STARR-positive B cell enhancer ABC_E8722 Neighboring gene STARR-seq mESC enhancer starr_44809 Neighboring gene ATPase, class I, type 8B, member 1 Neighboring gene predicted gene 6978 Neighboring gene STARR-seq mESC enhancer starr_44810 Neighboring gene STARR-seq mESC enhancer starr_44811 Neighboring gene predicted gene, 23016

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Dominant NARS1 mutations causing axonal Charcot-Marie-Tooth disease expand NARS1-associated diseases. Beijer D, et al. Brain Commun, 2024. PMID 38495304,
    2. Fibroblast growth factor 2-induced cytoplasmic asparaginyl-tRNA synthetase promotes survival of osteoblasts by regulating anti-apoptotic PI3K/Akt signaling. Park SJ, et al. Bone, 2009 Nov. PMID 19631775
    3. Inactivation of the 3-phosphoglycerate dehydrogenase gene in mice: changes in gene expression and associated regulatory networks resulting from serine deficiency. Furuya S, et al. Funct Integr Genomics, 2008 Aug. PMID 18228065
    4. A Dynamic Unfolded Protein Response Contributes to the Control of Cortical Neurogenesis. Laguesse S, et al. Dev Cell, 2015 Dec 7. PMID 26651292
    5. Disruption of mitochondrial complex III in cap mesenchyme but not in ureteric progenitors results in defective nephrogenesis associated with amino acid deficiency. Guan N, et al. Kidney Int, 2022 Jul. PMID 35341793, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NARS is one of the important mediators of FGF2 induced survival signaling in osteoblasts through the activation of PI3K/Akt survival pathway.
      Title: Fibroblast growth factor 2-induced cytoplasmic asparaginyl-tRNA synthetase promotes survival of osteoblasts by regulating anti-apoptotic PI3K/Akt signaling.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6)  1 citation
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables CCR3 chemokine receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables CCR3 chemokine receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables asparagine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables asparagine-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables asparagine-tRNA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein dimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein dimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in asparaginyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in asparaginyl-tRNA aminoacylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in asparaginyl-tRNA aminoacylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cerebral cortex development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cerebral cortex development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    asparagine--tRNA ligase, cytoplasmic
    Names
    asparaginyl-tRNA synthetase, cytoplasmic
    NP_001136422.2
    NP_001363950.1
    NP_001363951.1
    NP_001363952.1
    NP_081626.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142950.2 → NP_001136422.2  asparagine--tRNA ligase, cytoplasmic isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC102268
      Consensus CDS
      CCDS50308.1
      UniProtKB/Swiss-Prot
      Q3T9A7, Q7TPX0, Q8BP47, Q9CRY5
      Related
      ENSMUSP00000157402.2, ENSMUST00000237400.2
      Conserved Domains (1) summary
      COG0017
      Location:125 → 548
      AsnS; Aspartyl/asparaginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

    2. NM_001377021.1 → NP_001363950.1  asparagine--tRNA ligase, cytoplasmic isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC102268
      UniProtKB/Swiss-Prot
      Q3T9A7, Q7TPX0, Q8BP47, Q9CRY5
      Conserved Domains (1) summary
      COG0017
      Location:126 → 549
      AsnS; Aspartyl/asparaginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

    3. NM_001377022.1 → NP_001363951.1  asparagine--tRNA ligase, cytoplasmic isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC102268
      UniProtKB/Swiss-Prot
      Q3T9A7, Q7TPX0, Q8BP47, Q9CRY5
      Conserved Domains (1) summary
      COG0017
      Location:125 → 546
      AsnS; Aspartyl/asparaginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

    4. NM_001377023.1 → NP_001363952.1  asparagine--tRNA ligase, cytoplasmic isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC102268
      UniProtKB/TrEMBL
      A0A494BAX5
      Related
      ENSMUSP00000158278.2, ENSMUST00000237351.2
      Conserved Domains (1) summary
      COG0017
      Location:95 → 518
      AsnS; Aspartyl/asparaginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

    5. NM_027350.4 → NP_081626.3  asparagine--tRNA ligase, cytoplasmic isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC102268
      Consensus CDS
      CCDS89261.1
      UniProtKB/TrEMBL
      A0A498WGK2
      Related
      ENSMUSP00000025483.11, ENSMUST00000025483.11
      Conserved Domains (1) summary
      COG0017
      Location:124 → 547
      AsnS; Aspartyl/asparaginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      64632726..64649586 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BP47.2 GenPept UniProtKB/Swiss-Prot:Q8BP47

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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