Slc31a1 solute carrier family 31, member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc31a1provided by MGI
Official Full Name: solute carrier family 31, member 1provided by MGI
Primary source: MGI:MGI:1333843
See related: Ensembl:ENSMUSG00000066150 AllianceGenome:MGI:1333843
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ctr1; 4930445G01Rik
Summary: Enables copper ion transmembrane transporter activity; silver ion transmembrane transporter activity; and xenobiotic transmembrane transporter activity. Involved in angiogenesis; transition metal ion transport; and xenobiotic transport. Acts upstream of or within establishment of localization in cell and intracellular copper ion homeostasis. Located in several cellular components, including basolateral plasma membrane; endosome; and intercalated disc. Is expressed in several structures, including adrenal gland; alimentary system; early embryo; genitourinary system; and nervous system. Orthologous to human SLC31A1 (solute carrier family 31 member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in liver adult (RPKM 31.6), large intestine adult (RPKM 31.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 B3; 4 33.11 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (62278821..62310006)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (62360583..62391769)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protective effect of rosmarinic acid on the transmembrane transporter Ctr1 expression in cisplatin-treated mice.
Title: Protective effect of rosmarinic acid on the transmembrane transporter Ctr1 expression in cisplatin-treated mice.
Matrigel-based organoid culture of malignant mesothelioma reproduces cisplatin sensitivity through CTR1.
Title: Matrigel-based organoid culture of malignant mesothelioma reproduces cisplatin sensitivity through CTR1.
ATF3/SPI1/SLC31A1 Signaling Promotes Cuproptosis Induced by Advanced Glycosylation End Products in Diabetic Myocardial Injury.
Title: ATF3/SPI1/SLC31A1 Signaling Promotes Cuproptosis Induced by Advanced Glycosylation End Products in Diabetic Myocardial Injury.
Decreased Expression of the Slc31a1 Gene and Cytoplasmic Relocalization of Membrane CTR1 Protein in Renal Epithelial Cells: A Potent Protective Mechanism against Copper Nephrotoxicity in a Mouse Model of Menkes Disease.
Title: Decreased Expression of the Slc31a1 Gene and Cytoplasmic Relocalization of Membrane CTR1 Protein in Renal Epithelial Cells: A Potent Protective Mechanism against Copper Nephrotoxicity in a Mouse Model of Menkes Disease.
Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis.
Title: Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis.
Inhibition of copper transporter 1 prevents alpha-synuclein pathology and alleviates nigrostriatal degeneration in AAV-based mouse model of Parkinson's disease.
Title: Inhibition of copper transporter 1 prevents α-synuclein pathology and alleviates nigrostriatal degeneration in AAV-based mouse model of Parkinson's disease.
Results indicate the importance of high-affinity copper (Cu) transporter 1 (CTR1; SLC31A1) expression by meiotic germ cells (GCs) for maintaining functional spermatogenesis.
Title: Copper transporter 1 (CTR1) expression by mouse testicular germ cells, but not Sertoli cells, is essential for functional spermatogenesis.
Gene duplication and neo-functionalization in the evolutionary and functional divergence of the metazoan copper transporters Ctr1 and Ctr2
Title: Gene duplication and neo-functionalization in the evolutionary and functional divergence of the metazoan copper transporters Ctr1 and Ctr2.
studies identify a new processing event and the key protease that cleaves the Ctr1 metal-binding ectodomain, which functions to regulate cellular Cu(+) and cisplatin acquisition
Title: Cathepsin Protease Controls Copper and Cisplatin Accumulation via Cleavage of the Ctr1 Metal-binding Ectodomain.
CTR1, ATP7A, and lysyl oxidase were upregulated in the lung tissues and pulmonary arteries of mice with hypoxia-induced pulmonary hypertension and pulmonary arterial smooth muscle cells.
Title: Upregulated copper transporters in hypoxia-induced pulmonary hypertension.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Gene trapped (1)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc31a1 (e-PCR), detects polymorphism
- UniSTS:547081

AU016967 (e-PCR)
- UniSTS:159248

AI787263 (e-PCR)
- UniSTS:165330

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables copper ion binding	ISO Inferred from Sequence Orthology more info
enables copper ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables copper ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables copper ion transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables copper ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables copper ion transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables silver ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables silver ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables xenobiotic transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to cisplatin	ISO Inferred from Sequence Orthology more info
involved_in copper ion import	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within copper ion import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in copper ion import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in copper ion import	ISO Inferred from Sequence Orthology more info
involved_in copper ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in copper ion transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular copper ion homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in plasma membrane copper ion transport	ISO Inferred from Sequence Orthology more info
involved_in plasma membrane copper ion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein complex oligomerization	ISO Inferred from Sequence Orthology more info
involved_in protein complex oligomerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in silver ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in silver ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in vascular endothelial growth factor receptor-2 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in vascular endothelial growth factor receptor-2 signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in xenobiotic transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in xenobiotic transport	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome membrane	ISO Inferred from Sequence Orthology more info
located_in early endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in intercalated disc	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome membrane	ISO Inferred from Sequence Orthology more info
located_in recycling endosome membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: high affinity copper uptake protein 1

Names: copper transporter 1; solute carrier family 13 (sodium/sulphate symporters), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.