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    Cdc14b CDC14 cell division cycle 14B [ Mus musculus (house mouse) ]

    Gene ID: 218294, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cdc14bprovided by MGI
    Official Full Name
    CDC14 cell division cycle 14Bprovided by MGI
    Primary source
    MGI:MGI:2441808
    See related
    Ensembl:ENSMUSG00000033102 AllianceGenome:MGI:2441808
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CDC14B3; Cdc14B1; 2810432N10Rik; A530086E13Rik
    Summary
    Predicted to enable protein serine/threonine phosphatase activity and protein tyrosine phosphatase activity. Predicted to be involved in several processes, including positive regulation of ubiquitin protein ligase activity; protein dephosphorylation; and regulation of cell cycle process. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm; nucleolus; and spindle. Is expressed in embryo. Orthologous to several human genes including CDC14B (cell division cycle 14B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 6.1), placenta adult (RPKM 2.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cdc14b in Genome Data Viewer
    Location:
    13 B3; 13 33.26 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (64337085..64423670, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (64192545..64274988, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_34820 Neighboring gene zinc finger protein 367 Neighboring gene STARR-positive B cell enhancer ABC_E5404 Neighboring gene STARR-positive B cell enhancer ABC_E928 Neighboring gene STARR-positive B cell enhancer ABC_E7250 Neighboring gene hyaluronic acid binding protein 4 Neighboring gene STARR-seq mESC enhancer starr_34826 Neighboring gene predicted gene, 46424 Neighboring gene RIKEN cDNA 1810034E14 gene Neighboring gene peroxiredoxin like 2C Neighboring gene STARR-seq mESC enhancer starr_34827 Neighboring gene STARR-positive B cell enhancer ABC_E8894 Neighboring gene STARR-positive B cell enhancer ABC_E1879 Neighboring gene predicted gene, 31128

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Overexpression of CDC14B causes mitotic arrest and inhibits zygotic genome activation in mouse preimplantation embryos. Buffone MG, et al. Cell Cycle, 2009 Dec. PMID 19923902, Free PMC Article
    2. The Cdc14B phosphatase displays oncogenic activity mediated by the Ras-Mek signaling pathway. Chiesa M, et al. Cell Cycle, 2011 May 15. PMID 21502810
    3. CDC14B acts through FZR1 (CDH1) to prevent meiotic maturation of mouse oocytes. Schindler K, et al. Biol Reprod, 2009 Apr. PMID 19129509, Free PMC Article
    4. Cdc14A and Cdc14B Redundantly Regulate DNA Double-Strand Break Repair. Lin H, et al. Mol Cell Biol, 2015 Nov. PMID 26283732, Free PMC Article
    5. Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription. Guillamot M, et al. Sci Rep, 2011. PMID 22355704, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mis12 controls cyclin B1 stabilization via Cdc14B-mediated APC/C(Cdh1) regulation during meiotic G2/M transition in mouse oocytes.
      Title: Mis12 controls cyclin B1 stabilization via Cdc14B-mediated APC/C(Cdh1) regulation during meiotic G2/M transition in mouse oocytes.
    2. Cdc14B knockout (Cdc14B(-/-)) mouse embryonic fibroblasts showed defects in repairing ionizing radiation-induced DNA double-strand breaks, which occurred only at late passages when Cdc14A levels were low.
      Title: Cdc14A and Cdc14B Redundantly Regulate DNA Double-Strand Break Repair.
    3. Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription
      Title: Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription.
    4. Cdc14B has oncogenic activity in mammals and point to the Ras-MAP kinase pathway as a major effector pathway during oncogenic transformation.
      Title: The Cdc14B phosphatase displays oncogenic activity mediated by the Ras-Mek signaling pathway.
    5. Cdc14b is required for efficient DNA damage repair.
      Title: Early-onset aging and defective DNA damage response in Cdc14b-deficient mice.
    6. CDC14B is a negative regulator of the 1-to-2-cell transition and of zygotic genome activation in mouse embryogenesis.
      Title: Overexpression of CDC14B causes mitotic arrest and inhibits zygotic genome activation in mouse preimplantation embryos.
    7. CDC14B is a negative regulator of meiotic resumption and may regulate meiosis I in mouse oocytes.
      Title: CDC14B acts through FZR1 (CDH1) to prevent meiotic maturation of mouse oocytes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MAP kinase serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin-dependent protein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS140 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic G2 DNA damage checkpoint signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of exit from mitosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dual specificity protein phosphatase CDC14B
    Names
    CDC14 cell division cycle 14 homolog B
    NP_001116461.1
    NP_766175.3
    XP_006517282.1
    XP_006517290.1
    XP_006517292.1
    XP_011242817.1
    XP_036013890.1
    XP_036013891.1
    XP_036013892.1
    XP_036013893.1
    XP_036013894.1
    XP_036013895.1
    XP_036013896.1
    XP_036013897.1
    XP_036013898.1
    XP_036013899.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122989.1 → NP_001116461.1  dual specificity protein phosphatase CDC14B isoform 2

      See identical proteins and their annotated locations for NP_001116461.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1, resulting in the use of a novel start codon and a protein (isoform 2) with a shorter, distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK036045, AK041155, BY199064
      Consensus CDS
      CCDS49292.1
      UniProtKB/Swiss-Prot
      Q6PFY9
      Related
      ENSMUSP00000105391.3, ENSMUST00000109769.10
      Conserved Domains (2) summary
      pfam14671
      Location:17 → 151
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:209 → 323
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    2. NM_172587.3 → NP_766175.3  dual specificity protein phosphatase CDC14B isoform 1

      See identical proteins and their annotated locations for NP_766175.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK036045, AK041155, AK044332, CN720173
      Consensus CDS
      CCDS26598.1
      UniProtKB/Swiss-Prot
      Q6PFY9, Q80WC4, Q8BLV5
      Related
      ENSMUSP00000046003.9, ENSMUST00000039318.16
      Conserved Domains (2) summary
      cd14499
      Location:199 → 372
      CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
      cd17657
      Location:52 → 190
      CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      64337085..64423670 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158005.1 → XP_036013898.1  dual specificity protein phosphatase CDC14B isoform X11

      Conserved Domains (2) summary
      cd14499
      Location:199 → 372
      CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
      cd17657
      Location:52 → 190
      CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins

    2. XM_036157997.1 → XP_036013890.1  dual specificity protein phosphatase CDC14B isoform X1

      Conserved Domains (2) summary
      cd14499
      Location:199 → 372
      CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
      cd17657
      Location:52 → 190
      CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins

    3. XM_036158001.1 → XP_036013894.1  dual specificity protein phosphatase CDC14B isoform X6

      Conserved Domains (2) summary
      cd14499
      Location:199 → 372
      CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
      cd17657
      Location:52 → 190
      CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins

    4. XM_036158000.1 → XP_036013893.1  dual specificity protein phosphatase CDC14B isoform X5

      UniProtKB/TrEMBL
      A0A1Y7VJB9
      Related
      ENSMUSP00000152388.2, ENSMUST00000221634.2
      Conserved Domains (2) summary
      cd14499
      Location:199 → 372
      CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
      cd17657
      Location:52 → 190
      CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins

    5. XM_036157998.1 → XP_036013891.1  dual specificity protein phosphatase CDC14B isoform X3

      Conserved Domains (2) summary
      cd14499
      Location:199 → 372
      CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
      cd17657
      Location:52 → 190
      CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins

    6. XM_006517227.4 → XP_006517290.1  dual specificity protein phosphatase CDC14B isoform X10

      Conserved Domains (2) summary
      cd14499
      Location:162 → 335
      CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
      pfam14671
      Location:13 → 151
      DSPn; Dual specificity protein phosphatase, N-terminal half

    7. XM_036157999.1 → XP_036013892.1  dual specificity protein phosphatase CDC14B isoform X4

      Conserved Domains (2) summary
      cd14499
      Location:199 → 372
      CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
      cd17657
      Location:52 → 190
      CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins

    8. XM_036158006.1 → XP_036013899.1  dual specificity protein phosphatase CDC14B isoform X13

      Conserved Domains (1) summary
      cd14499
      Location:10 → 183
      CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins

    9. XM_006517229.3 → XP_006517292.1  dual specificity protein phosphatase CDC14B isoform X12

      Conserved Domains (1) summary
      cd14499
      Location:10 → 183
      CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins

    10. XM_006517219.1 → XP_006517282.1  dual specificity protein phosphatase CDC14B isoform X2

      Conserved Domains (2) summary
      cd14499
      Location:162 → 335
      CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
      pfam14671
      Location:13 → 151
      DSPn; Dual specificity protein phosphatase, N-terminal half

    11. XM_011244515.4 → XP_011242817.1  dual specificity protein phosphatase CDC14B isoform X9

      Conserved Domains (2) summary
      cd14499
      Location:104 → 277
      CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
      pfam14671
      Location:1 → 93
      DSPn; Dual specificity protein phosphatase, N-terminal half

    12. XM_036158003.1 → XP_036013896.1  dual specificity protein phosphatase CDC14B isoform X7

      UniProtKB/Swiss-Prot
      Q6PFY9, Q80WC4, Q8BLV5
      Conserved Domains (2) summary
      cd14499
      Location:199 → 372
      CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
      cd17657
      Location:52 → 190
      CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins

    13. XM_036158004.1 → XP_036013897.1  dual specificity protein phosphatase CDC14B isoform X8

      Conserved Domains (2) summary
      cd14499
      Location:199 → 372
      CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
      cd17657
      Location:52 → 190
      CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins

    14. XM_036158002.1 → XP_036013895.1  dual specificity protein phosphatase CDC14B isoform X7

      UniProtKB/Swiss-Prot
      Q6PFY9, Q80WC4, Q8BLV5
      Conserved Domains (2) summary
      cd14499
      Location:199 → 372
      CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
      cd17657
      Location:52 → 190
      CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins

    RNA

    1. XR_004938019.1 RNA Sequence

    2. XR_004938022.1 RNA Sequence

    3. XR_004938021.1 RNA Sequence

    4. XR_873438.3 RNA Sequence

    5. XR_004938020.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PFY9.1 GenPept UniProtKB/Swiss-Prot:Q6PFY9

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