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    Htra4 HtrA serine peptidase 4 [ Mus musculus (house mouse) ]

    Gene ID: 330723, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Htra4provided by MGI
    Official Full Name
    HtrA serine peptidase 4provided by MGI
    Primary source
    MGI:MGI:3036260
    See related
    Ensembl:ENSMUSG00000037406 AllianceGenome:MGI:3036260
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B430206E18Rik
    Summary
    Predicted to enable identical protein binding activity and serine-type endopeptidase activity. Predicted to be involved in positive regulation of apoptotic process; programmed cell death; and proteolysis. Predicted to be located in extracellular region. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system gland; lung; and muscle tissue. Orthologous to human HTRA4 (HtrA serine peptidase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in adrenal adult (RPKM 3.8), lung adult (RPKM 1.2) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Htra4 in Genome Data Viewer
    Location:
    8 A2; 8 13.7 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (25514944..25529160, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (25024928..25038962, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20952 Neighboring gene ADAM metallopeptidase domain 9 Neighboring gene STARR-positive B cell enhancer mm9_chr8:26127373-26127674 Neighboring gene TM2 domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E6628 Neighboring gene pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2 Neighboring gene STARR-positive B cell enhancer ABC_E11381 Neighboring gene RIKEN cDNA 5830408C22 gene Neighboring gene STARR-positive B cell enhancer mm9_chr8:26213490-26213791 Neighboring gene STARR-seq mESC enhancer starr_20960 Neighboring gene STARR-positive B cell enhancer ABC_E8231 Neighboring gene STARR-positive B cell enhancer ABC_E11742 Neighboring gene STARR-positive B cell enhancer ABC_E6629 Neighboring gene STARR-seq mESC enhancer starr_20962 Neighboring gene STARR-seq mESC enhancer starr_20963 Neighboring gene predicted gene, 39143

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Generation and characterization of mice with a conditional null allele of the HtrA4 gene. Liu J, et al. Mol Med Rep, 2015 Nov. PMID 26353049, Free PMC Article
    2. A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging. Patterson VL, et al. J Vis Exp, 2016 Jul 14. PMID 27500671
    3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in programmed cell death IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine protease HTRA4
    Names
    high-temperature requirement factor A4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081187.3 → NP_001074656.1  serine protease HTRA4 precursor

      See identical proteins and their annotated locations for NP_001074656.1

      Status: VALIDATED

      Source sequence(s)
      AK046614, AV315397, BB619816, BC145842
      Consensus CDS
      CCDS40301.1
      UniProtKB/Swiss-Prot
      A2RT60
      Related
      ENSMUSP00000081044.5, ENSMUST00000084031.6
      Conserved Domains (5) summary
      smart00280
      Location:121 → 140
      KAZAL; Kazal type serine protease inhibitors
      COG0265
      Location:145 → 479
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00987
      Location:386 → 477
      PDZ_serine_protease; PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind ...
      pfam00219
      Location:39 → 93
      IGFBP; Insulin-like growth factor binding protein
      pfam13365
      Location:208 → 346
      Trypsin_2; Trypsin-like peptidase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      25514944..25529160 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154107.1 → XP_036010000.1  serine protease HTRA4 isoform X1

      Conserved Domains (3) summary
      TIGR02037
      Location:222 → 494
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
      pfam00219
      Location:85 → 139
      IGFBP; Insulin-like growth factor binding protein
      pfam07648
      Location:156 → 204
      Kazal_2; Kazal-type serine protease inhibitor domain

    2. XM_036154108.1 → XP_036010001.1  serine protease HTRA4 isoform X2

      Conserved Domains (3) summary
      TIGR02037
      Location:222 → 476
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
      pfam00219
      Location:85 → 139
      IGFBP; Insulin-like growth factor binding protein
      pfam07648
      Location:156 → 204
      Kazal_2; Kazal-type serine protease inhibitor domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2RT60.1 GenPept UniProtKB/Swiss-Prot:A2RT60

    Gene LinkOut

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