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    Rasal2 RAS protein activator like 2 [ Mus musculus (house mouse) ]

    Gene ID: 226525, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rasal2provided by MGI
    Official Full Name
    RAS protein activator like 2provided by MGI
    Primary source
    MGI:MGI:2443881
    See related
    Ensembl:ENSMUSG00000070565 AllianceGenome:MGI:2443881
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6530401P13; A330066M24Rik
    Summary
    Involved in several processes, including adipose tissue development; response to dietary excess; and response to glucose. Is expressed in central nervous system; dorsal root ganglion; nose; and turbinate bone primordium. Orthologous to human RASAL2 (RAS protein activator like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in whole brain E14.5 (RPKM 6.2), CNS E14 (RPKM 5.6) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rasal2 in Genome Data Viewer
    Location:
    1 H1; 1 67.97 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (156962759..157240170, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (157135183..157412595, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene testis expressed 35 Neighboring gene predicted gene, 30694 Neighboring gene predicted gene, 51654 Neighboring gene mortality factor 4 like 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_02764 Neighboring gene ash2 (absent, small, or homeotic)-like pseudogene Neighboring gene RIKEN cDNA 2810025M15 gene Neighboring gene STARR-positive B cell enhancer ABC_E5829 Neighboring gene GABA(A) receptor-associated protein-like 2 pseudogene 1_1522.1 Neighboring gene STARR-seq mESC enhancer starr_02765 Neighboring gene STARR-seq mESC enhancer starr_02769 Neighboring gene STARR-seq mESC enhancer starr_02770 Neighboring gene crystallin zeta like 2 Neighboring gene predicted gene, 57801

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RAS protein activator-like 2 (RASAL2) initiates peritubular capillary rarefaction in hypoxic renal interstitial fibrosis. Zhang Y, et al. Transl Res, 2024 Jul. PMID 38453052
    2. RAS protein activator like 2 promotes the proliferation and migration of pulmonary artery smooth muscle cell through AKT/mammalian target of Rapamycin complex 1 pathway in pulmonary hypertension. Hu S, et al. Bioengineered, 2022 Feb. PMID 35044284, Free PMC Article
    3. RASAL2 promotes lung cancer metastasis through epithelial-mesenchymal transition. Li N, et al. Biochem Biophys Res Commun, 2014 Dec 12. PMID 25446096
    4. The RasGAP gene, RASAL2, is a tumor and metastasis suppressor. McLaughlin SK, et al. Cancer Cell, 2013 Sep 9. PMID 24029233, Free PMC Article
    5. Silencing of lncRNA SNHG20 delays the progression of nonalcoholic fatty liver disease to hepatocellular carcinoma via regulating liver Kupffer cells polarization. Wang B, et al. IUBMB Life, 2019 Dec. PMID 31408278

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RAS protein activator-like 2 (RASAL2) initiates peritubular capillary rarefaction in hypoxic renal interstitial fibrosis.
      Title: RAS protein activator-like 2 (RASAL2) initiates peritubular capillary rarefaction in hypoxic renal interstitial fibrosis.
    2. RAS protein activator like 2 promotes the proliferation and migration of pulmonary artery smooth muscle cell through AKT/mammalian target of Rapamycin complex 1 pathway in pulmonary hypertension.
      Title: RAS protein activator like 2 promotes the proliferation and migration of pulmonary artery smooth muscle cell through AKT/mammalian target of Rapamycin complex 1 pathway in pulmonary hypertension.
    3. Rasal2 deficiency leads to impaired adipogenesis in vivo and in vitro. Rasal2 deficiency resulted in increased activity of Ras and ERK in preadipocytes.
      Title: Rasal2 deficiency reduces adipogenesis and occurrence of obesity-related disorders.
    4. the down-regulation of RASAL2 promotes metastatic progression of lung adenocarcinoma
      Title: RASAL2 promotes lung cancer metastasis through epithelial-mesenchymal transition.
    5. The RasGAP gene, RASAL2, is a tumor and metastasis suppressor
      Title: The RasGAP gene, RASAL2, is a tumor and metastasis suppressor.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (2) 
    • Transposon induced (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in adipose tissue development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein activation cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to dietary excess IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to glucose IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ras GTPase-activating protein nGAP

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401202.1 → NP_001388131.1  ras GTPase-activating protein nGAP isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC119220, AC119897, AC138382
      UniProtKB/TrEMBL
      D3YUS5
      Related
      ENSMUSP00000114964.2, ENSMUST00000132699.8

    2. NM_177644.6 → NP_808312.3  ras GTPase-activating protein nGAP isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC119220, AC119897, AC138382
      Consensus CDS
      CCDS48408.1
      UniProtKB/TrEMBL
      E9PW37, Q0VAV5
      Related
      ENSMUSP00000077423.7, ENSMUST00000078308.13
      Conserved Domains (6) summary
      cd04013
      Location:306 → 445
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:436 → 766
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:429 → 767
      RasGAP; GTPase-activator protein for Ras-like GTPases
      pfam12004
      Location:756 → 1248
      DUF3498; Domain of unknown function (DUF3498)
      cl02488
      Location:1110 → 1258
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl17171
      Location:181 → 364
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      156962759..157240170 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496751.3 → XP_006496814.1  ras GTPase-activating protein nGAP isoform X2

      UniProtKB/TrEMBL
      D3YUS5
      Conserved Domains (4) summary
      cd04013
      Location:306 → 445
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:436 → 759
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      pfam12004
      Location:749 → 1225
      DUF3498; Domain of unknown function (DUF3498)
      cl17171
      Location:181 → 364
      PH-like; Pleckstrin homology-like domain

    2. XM_006496750.3 → XP_006496813.1  ras GTPase-activating protein nGAP isoform X1

      UniProtKB/TrEMBL
      Q0VAV5
      Conserved Domains (4) summary
      cd04013
      Location:306 → 445
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:436 → 766
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      pfam12004
      Location:756 → 1232
      DUF3498; Domain of unknown function (DUF3498)
      cl17171
      Location:181 → 364
      PH-like; Pleckstrin homology-like domain

    3. XM_036164040.1 → XP_036019933.1  ras GTPase-activating protein nGAP isoform X8

      UniProtKB/TrEMBL
      D3YUS5
      Conserved Domains (4) summary
      cd04013
      Location:159 → 298
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:289 → 612
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      pfam12004
      Location:602 → 1078
      DUF3498; Domain of unknown function (DUF3498)
      cl17171
      Location:34 → 217
      PH-like; Pleckstrin homology-like domain

    4. XM_006496755.4 → XP_006496818.1  ras GTPase-activating protein nGAP isoform X6

      UniProtKB/TrEMBL
      Q0VAV5
      Conserved Domains (4) summary
      cd04013
      Location:159 → 298
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:289 → 619
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      pfam12004
      Location:609 → 1085
      DUF3498; Domain of unknown function (DUF3498)
      cl17171
      Location:34 → 217
      PH-like; Pleckstrin homology-like domain

    5. XM_006496753.5 → XP_006496816.1  ras GTPase-activating protein nGAP isoform X4

      UniProtKB/TrEMBL
      Q0VAV5
      Conserved Domains (4) summary
      cd04013
      Location:242 → 381
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:372 → 702
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      pfam12004
      Location:692 → 1168
      DUF3498; Domain of unknown function (DUF3498)
      cl17171
      Location:117 → 300
      PH-like; Pleckstrin homology-like domain

    6. XM_006496756.5 → XP_006496819.1  ras GTPase-activating protein nGAP isoform X9

      UniProtKB/TrEMBL
      Q0VAV5
      Conserved Domains (4) summary
      cd04013
      Location:131 → 270
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:261 → 591
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      pfam12004
      Location:581 → 1057
      DUF3498; Domain of unknown function (DUF3498)
      cl17171
      Location:6 → 189
      PH-like; Pleckstrin homology-like domain

    7. XM_006496754.4 → XP_006496817.1  ras GTPase-activating protein nGAP isoform X5

      UniProtKB/TrEMBL
      Q0VAV5
      Conserved Domains (4) summary
      cd04013
      Location:178 → 317
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:308 → 638
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      pfam12004
      Location:628 → 1104
      DUF3498; Domain of unknown function (DUF3498)
      cl17171
      Location:53 → 236
      PH-like; Pleckstrin homology-like domain

    8. XM_036164037.1 → XP_036019930.1  ras GTPase-activating protein nGAP isoform X7

      UniProtKB/TrEMBL
      D3YUS5
      Conserved Domains (4) summary
      cd04013
      Location:178 → 317
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:308 → 631
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      pfam12004
      Location:621 → 1097
      DUF3498; Domain of unknown function (DUF3498)
      cl17171
      Location:53 → 236
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein Strain
    Heading Accession and Version

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