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    HSP33 glutathione-independent methylglyoxalase family protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854573, updated on 9-Dec-2024

    Summary

    Official Symbol
    HSP33
    Official Full Name
    glutathione-independent methylglyoxalase family protein
    Primary source
    SGD:S000005918
    Locus tag
    YOR391C
    See related
    AllianceGenome:SGD:S000005918; FungiDB:YOR391C; VEuPathDB:YOR391C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable glyoxalase III activity and protein folding chaperone. Involved in cellular response to nutrient levels. Predicted to be located in P-body. Predicted to be active in cytoplasm. Used to study Parkinson's disease and cancer. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See HSP33 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (1078545..1079258, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene fluoride transporter Neighboring gene phosphopyruvate hydratase ERR1 Neighboring gene seripauperin PAU21

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables glyoxalase III activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glyoxalase III activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein folding chaperone ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to nutrient levels IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chaperone-mediated protein folding ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    involved_in lactate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in P-body IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cellular_component ND
    No biological Data available
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    glutathione-independent methylglyoxalase family protein
    NP_015036.3
    • Possible chaperone and cysteine protease; required for transcriptional reprogramming during the diauxic shift and for survival in stationary phase; similar to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp32p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease and cancer

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      1078545..1079258 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183811.3NP_015036.3  TPA: glutathione-independent methylglyoxalase family protein [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015036.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W384, Q08914
      UniProtKB/TrEMBL
      A6ZVX8
      Conserved Domains (1) summary
      cl00020
      Location:5235
      GAT_1; Type 1 glutamine amidotransferase (GATase1)-like domain